In Vivo Models of Inflammation

Volume 2
2. Auflage 2006
ISBN: 978-3-7643-7760-1
Verlag: Springer
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 203 Seiten

In Vivo Models of Inflammation (Vol. 2) provides biomedical researchers in both the pharmaceutical industry and academia with a description of the state-of-the-art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first, describing and updating the standard models that are most utilized for specific disease areas. New models are included exploring emerging areas of inflammation research.

Autoren/Hrsg.

Inhaltsverzeichnis

1;Contents;5
2;List of contributors;6
3;Preface to the first edition;8
4;Preface to the second edition;9
4.1;Introduction;10
5;Asthma;10
5.1;Mouse models;11
5.2;Guinea pig models;17
5.3;Rat models;18
5.4;Rabbit models;21
5.5;Canine models;21
5.6;Sheep models;22
5.7;Primate models;23
5.8;References;26
5.9;Introduction;38
5.10;Chronic obstructive pulmonary disease;38
6;In vivo modeling systems for chronic obstructive pulmonary disease;38
6.1;Elastase-induced lung inflammation and emphysema;41
6.2;Cigarette smoke-induced inflammation and lung destruction;46
6.3;Future directions;55
6.4;Conclusion;56
6.5;References;57
6.6;Introduction;67
7;Murine models of allergen-induced airway hyperresponsiveness and inflammation;67
7.1;Murine models of allergen-induced AHR and inflammation: functional assessments;69
7.2;Significance of murine models;76
7.3;References;85
7.4;Introduction;92
8;Skin inflammatory disorders;92
8.1;Atopic dermatitis models;94
8.2;Psoriasis models;105
8.3;Summary;118
8.4;References;120
8.5;Introduction;128
9;In vivo models of neurogenic inflammation;128
9.1;Neurogenic arterial vasodilatation and plasma extravasation;131
9.2;Mucus secretion;134
9.3;Motor effects in the airways and urinary tract;136
9.4;References;137
9.5;Introduction;143
10;Animal models of inflammatory bowel disease;143
10.1;Spontaneous or natural models;147
10.2;Immunological, bacterial and bacterial byproduct model;153
10.3;Animal models of physical injury;155
10.4;Genetically engineered models;161
10.5;Adoptive transfer models;167
10.6;Concluding remarks;168
10.7;References;168
10.8;Introduction;181
11;Preclinical models of vascular inflammation;181
11.1;Models of vascular inflammation;184
11.2;Conclusions;194
11.3;References;194
12;Index;204
13;The PIR-Series Progress in Inflammation Research;209