Janigro The Cell Cycle in the Central Nervous System

1. Auflage 2008
ISBN: 978-1-59745-021-8
Verlag: Humana Press
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 563 Seiten

Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.

Autoren/Hrsg.

Janigro, Damir

Inhaltsverzeichnis

1;Preface;6
2;Acknowledgmen;8
3;Contents;9
4;Contributors;12
5;Companion CD;16
6;CELL CYCLE DURING THE DEVELOPMENT OF THE MAMMALIAN CENTRAL NERVOUS SYSTEM;17
6.1;Methodological Considerations in the Evaluation of the Cell Cycle in the Central Nervous System;18
6.2;Neural Stem Cells;28
6.3;Progenitors and Precursors of Neuronsand Glial Cells;38
6.4;Vasculogenesis and Angiogenesis;45
6.5;Neuronal Migration and Malformationsof Cortical Development;56
7;POSTNATAL DEVELOPMENT OF NEURONS AND GLIA;69
7.1;Genome-Wide Expression Profilingof Neurogenesis in Relation to Cell Cycle Exit;70
7.2;Neurogenesis and Apoptotic Cell Death;82
7.3;Ion Channels and the Cell Cycle;91
7.4;Nonsynaptic GABAergic Communication and Postnatal Neurogenesis;105
7.5;Critical Roles of Ca 2+and K + Homeostasisin Apoptosis;115
7.6;Mammalian Neural Stem Cell Renewal;129
8;CONTROL OF THE CELL CYCLE AND APOPTOSIS IN GLIA;150
8.1;Methods of Determining Apoptosisin Neuro-Oncology;151
8.2;Cell Cycle, Neurological Disorders,and Reactive Gliosis;170
8.3;Potassium Channels, Cell Cycle, and Tumorigenesisin the Central Nervous System;183
9;ADULT NEUROGENESIS: A MECHANISM FOR BRAIN REPAIR?;198
9.1;Enhanced Neurogenesis Following Neurological Disease ;199
9.2;Endothelial Injury and Cell Cycle Re- Entry;211
9.3;The Contribution of Bone Marrow-Derived Cellsto Cerebrovascular Formation and Integrity;224
9.4;Microvessel Remodeling in Cerebral Ischemia;235
9.5;Vascular and Neuronal Effects of VEGF in the Nervous System;247
9.6;Epidermal Growth Factor Receptor in the Adult Brain;267
10;CELL CYCLE RE-ENTRY: A MECHANISM OF BRAIN DISEASE?;280
10.1;Neurodegeneration and Loss of Cell CycleControl in Postmitotic Neurons;281
10.2;Cell Cycle Activation and the Amyloid- Protein in Alzheimer's Disease;298
10.3;Neuronal Precursor Proliferation and Epileptic Malformations of Cortical Development;308
10.4;Vascular Differentiation and the Cell Cycle;318
10.5;Adult Neurogenesis and Central Nervous System Cell Cycle Analysis;329
10.6;Neurogenesis in Alzheimer's Disease;357
11;THE BIOLOGY OF GLIOMAS;369
11.1;p53 and Multidrug Resistance Transportersin the Central Nervous System;370
11.2;Signaling Modules in Glial Tumorsand Implications for Molecular Therapy;386
11.3;Detection of Proliferation in Gliomas by Positron Emission Tomography Imaging;416
11.4;Transformation of Normal AstrocytesInto a Tumor Phenotype;430
11.5;Mechanisms of Gliomagenesis;445
12;FUTURE DIRECTIONS;459
12.1;Cell Cycle of Encapsulated Cells;460
12.2;Viral Vector Delivery to Dividing Cells;471
12.3;Electrical Stimulation and Angiogenesis;488
12.4;Developmental and Potential Therapeutic Aspectsof Mammalian Neural Stem Cells;503
12.5;Mammalian Sir2 Proteins;517
13;Index;533