Jasmin / Capanna / Coia Textbook of Bone Metastases

1. Auflage 2005
ISBN: 978-0-470-01160-7
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 582 Seiten, E-Book

The epidemiological and clinical importance of bone metastases haslong been recognised. For example, the incidence of bone metastasesin breast and prostate cancers is 70%, whereas it is only 30 to 40%in metastatic lung cancer. In clinical terms, bone metastases havesubstantial negative effects on the patient's quality of life.
Bone metastases have generally received insufficient attentionbecause of the difficulty in quantifying them, which has left themoutside the scope of therapeutic trials
This textbook is the result of the remarkable progress made inthe understanding of the molecular and cellular mechanisms involvedin osteogenesis and osteolysis, and their development fortherapeutic purposes. The treatment of malignant hypercalcaemia hasalso been revolutionised by the use of bisphosphonates.
The Textbook of Bone Metastases presents a broad approachto recent progress in all fields related to bone metastases,ranging from epidemiology to the physiopathology of bone metastasesand therapeutics. It provides a better understanding of recentadvances and, more importantly, will give clinicians all theinformation needed to help them in the clinical and therapeuticmanagement of patients with bone metastases.

Autoren/Hrsg.

Jasmin, Claude

Capanna, Rodolfo

Coia, Lawrence

Coleman, Robert

Saillant, Gerard

Inhaltsverzeichnis

Contributors
Preface.
SECTION 1: BIOLOGY OF BONE METASTASES (R. Coleman).
1. General mechanisms of metastasis (S. Eccles).
2. Parathyroid hormone-related Protein and Bone metastases(T. Martin, et al.).
3. Osteoblastic Metastases (P. Croucher).
4. The Role of RANK, RANK Ligand and Osteoprotegerin in theLytic Effects and Growth of Bone Metastases (C. Dunstan).
SECTION 2: CLINICAL FEATURES AND ASSESSMENT (R. Coleman).
5. Clinical Features and Prognosis of Bone Metastases (T.Plunkett & R. Rubens).
6. Radio-isotope and PET Imaging of Bone Metastases (G. Cook& I. Fogelman).
7. Imaging of Spinal Bone Metastases (R. Guillevin, et al.).
8. Monitoring Response to Treatment - the Role of BiochemicalMarkers (R. Coleman & J. Brown).
9.Surgical Biopsy of Bone Metastases (M. Salaï & I.Dudliewicz).
SECTION 3: SURGICAL TREATMENT (R. Capanna).
10. Indications for the Surgical Treatment of Long BoneMetastases (R. Capanna & D. Campanacci).
11. Prosthetic Replacement in Long Bone Metastases (B. Fuchs, etal.).
12. Osteosynthesis for Pathological Fractures in Long Bones (P.Dijksta & A. Taminiau).
13. Surgical Treatment of Pelvic Metastases (R. Windhager).
14. Indications and Strategy for the Treatment of SpinalMetastases (E. Enkaoua).
15. Surgical Techniques for the Treatment of Bone Metastases ofthe Spine (S.Boriani) .
16. Total En Bloc Spondylectomy for Spinal Metastases (N.Kawahara, et al.).
SECTION 4: LOCAL TREATMENTS (L. Coia).
17. External Beam Radiation Therapy for the Treatment of BoneMetastases - (P. Anderson & L. Coia) .
18. Interventional Radiology for Bone Metastases (J. Chiras, etal.).
19. Percutaneous Injection of Ethanol (A. Cotten & L.Ceugnari).
SECTION 5: SYSTEMIC TREATMENTS (C. Jasmin).
20. Chemotherapy - (M. Green & G. Hortobagyi).
21. Endocrine Treatment of Bone Metastases (S. Agelaki & V.Georgoulias).
22. Overview of Osteoclast Inhibitors (J. Body).
23. Radioisotopes and Radioimmunoisotopes (I. Resche,et al.).
24. Immunotherapy (T. Plunkett & D. Miles).
SECTION 6: BISPHOSPHONATES (R. Coleman).
25. Mechanisms of Action of Bisphosphonates (M. Rogers).
26. Antitumor Effects of Bisphosphonates (P.Clézardin).
27. Management of Hypercalcaemia (S. Ralston).
28. Treatment of Lytic Bone Metastases (K. Gwyn & R.Theriault).
29. Use in Multiple Myeloma (J. Berenson).
30. Use in Prostate Cancer (R. Coleman).
31. Prevention of Bone Metastases (R. Coleman &H.Neville-Webbe).
32 Prevention of Bone Loss (R. Ashford, et al.).
33. Cost Implications of Bisphosphonates (E. McCloskey, etal.).
SECTION 7: THE GLOBAL APPROACH (C. Jasmin).
34. Treatment of Bone Pain (D. Lossignol).
35. Specific Approaches to Cancer in the Elderly (L.Balducci).
36. Psychological and Social Aspects (O. Gilbar).
37. Metabolic Bone Diseases in Childhood Cancer (V. Tillman, etal.).
SECTION 8: BONE METASTASES IN SPECIFIC TUMOURS (L. Coia).
38. Breast Cancer (W. Hartsell).
39. Prostate Cancer (E. Chow, et al.).
40. Multiple Myeloma (R. Kyle).
41. Malignant Non-Hodgkin's Lymphoma (O. Reman).
42. Lung Cancer (D. Roos).
43. Kidney Cancer (U Malik & M. Mohiuddin).
44. Evaluation of the Patient with Bone Metastases atPresentation (P. Hoskin).
Index.

Über Autor(innen)

Claude Jasmin is the editor of Textbook of Bone Metastases, published by Wiley.

Rodolfo Capanna is the editor of Textbook of Bone Metastases, published by Wiley.

Lawrence Coia is the editor of Textbook of Bone Metastases, published by Wiley.

Robert Coleman is the editor of Textbook of Bone Metastases, published by Wiley.

Gerard Saillant is the editor of Textbook of Bone Metastases, published by Wiley.