E-Book, Englisch, 370 Seiten, E-Book
Kalden / Herrmann Apoptosis and Autoimmunity
1. Auflage 2006
ISBN: 978-3-527-60529-3
Verlag: Wiley-VCH
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
From Mechanisms to Treatments
E-Book, Englisch, 370 Seiten, E-Book
ISBN: 978-3-527-60529-3
Verlag: Wiley-VCH
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)
In zahlreichen Untersuchungen sind Zusammenhänge zwischen Apoptose und Autoimmunität beobachtet worden. Dies ist das erste Buch zu diesem in Zellbiologie und Immunologie intensiv diskutierten Thema. Beobachtungen an Tiermodellen und Patienten tragen zur Aufklärung der Entstehung häufiger rheumatischer Erkrankungen und zur Entwicklung neuer, spezifischer Therapien bei. In diesem Buch stellt ein international renommiertes Autorenteam dar, wie die fehlerhafte Entfernung apoptotischer Zellen auf molekularer und zellulärer Ebene zu Autoimmunkrankheiten führen kann. Ein Glossar mit über 200 Stichworten, viele davon zum ersten Mal definiert, rundet diese umfassende Übersicht ab.
Autoren/Hrsg.
Weitere Infos & Material
GENERAL FEATURES of APOPTOSIS
Apoptosis and Autoimmunity (Keith, Elkon)
Caspase Knockouts: Matters of Life and Death (Lakhani, Lu, Flavell)
CLEARANCE OF APOPTOTIC CELLS
Anti-inflammatory and Immunoregulatory Effects of Apoptotic Cells (Voll, Herrmann Girkontaite, Kolowos, Kalden)
Complement and Apoptosis (Mevorach)
Soluble Factors that Bind to Dying Cells Control the Outcome of Corpse Disposal: the Role of Pentraxins, Collectins, and Auto-antibodies (Rovere-Querini)
The Role of ATP-binding Cassette Transporters in the Clearance of Apoptotic Cells: A Tale of Two Systems (Rigot, Chimini)
Innate Immunity and Apoptosis: CD14-dependent Clearance of Apoptotic Cells (Gregory, Devitt)
AUTOIMMUNITY CAUSED BY DEFECTIVE EXECUTION OF APOPTOSIS OR DEFECTIVE CLEARANCE OF APOPTOTIC CELLS
Autoimmune Lymphoproliferative Syndromes (ALPS) (Rieux-Laucat, Deist, Fischer)
Infection and Inflammation as Cofactors for Autoimmunity of Systematic Lupus Erythematosus Patients (Lorenz)
Apoptosis in Rheumatoid Arthritis (Yamanishi, Firestein)
Systemic Lupus Erythematosus (SLE) (Beyer, Kuenkele, Gaipl, Kolowos, Voll, Baumann, Kalden, Herrmann)
IMMUNOGENICITY OF APOPTOTIC CELLS
Dendritic Cells Pulsed with Apoptotic Tumour Cells as Vaccines (Jenne, Sauter)
The Immune Response against Apoptotic Cells (Manfredi)
"ALTERED SELF" IN DYING CELLS
Autoantigens as Substrates for Apoptotic Proteases: Implications for the Pathogenesis of Systemic Autoimmune Disease (Rosen, Casciola-Rosen)
Distinct Cleavage Products of Nuclear Autoantigens in Apoptosis and Necrosis: Implications for Autoimmunity (Casiano, Molinaro, Holder, Wu)
'Tissue' Transglutaminase and Autoimmunity (Amendola, Piacentini)
Modification of RNA - Antigens in apoptosis (Utz)
THE ROLE OF DNA BINDING PROTEINS FOR SYSTEMIC AUTOIMMUNITY
Nucleosomes and anti-Nucleosome Autoantibodies as Mediators of Glomerular Pathology in Systemic Lupus Erythematosus (Dieker, van der Vlag Berden)
GLOSSARY
GENERAL FEATURES of APOPTOSIS
Apoptosis and Autoimmunity (Keith, Elkon)
Caspase Knockouts: Matters of Life and Death (Lakhani, Lu, Flavell)
CLEARANCE OF APOPTOTIC CELLS
Anti-inflammatory and Immunoregulatory Effects of Apoptotic Cells (Voll, Herrmann Girkontaite, Kolowos, Kalden)
Complement and Apoptosis (Mevorach)
Soluble Factors that Bind to Dying Cells Control the Outcome of Corpse Disposal: the Role of Pentraxins, Collectins, and Auto-antibodies (Rovere-Querini)
The Role of ATP-binding Cassette Transporters in the Clearance of Apoptotic Cells: A Tale of Two Systems (Rigot, Chimini)
Innate Immunity and Apoptosis: CD14-dependent Clearance of Apoptotic Cells (Gregory, Devitt)
AUTOIMMUNITY CAUSED BY DEFECTIVE EXECUTION OF APOPTOSIS OR DEFECTIVE CLEARANCE OF APOPTOTIC CELLS
Autoimmune Lymphoproliferative Syndromes (ALPS) (Rieux-Laucat, Deist, Fischer)
Infection and Inflammation as Cofactors for Autoimmunity of Systematic Lupus Erythematosus Patients (Lorenz)
Apoptosis in Rheumatoid Arthritis (Yamanishi, Firestein)
Systemic Lupus Erythematosus (SLE) (Beyer, Kuenkele, Gaipl, Kolowos, Voll, Baumann, Kalden, Herrmann)
IMMUNOGENICITY OF APOPTOTIC CELLS
Dendritic Cells Pulsed with Apoptotic Tumour Cells as Vaccines (Jenne, Sauter)
The Immune Response against Apoptotic Cells (Manfredi)
"ALTERED SELF" IN DYING CELLS
Autoantigens as Substrates for Apoptotic Proteases: Implications for the Pathogenesis of Systemic Autoimmune Disease (Rosen, Casciola-Rosen)
Distinct Cleavage Products of Nuclear Autoantigens in Apoptosis and Necrosis: Implications for Autoimmunity (Casiano, Molinaro, Holder, Wu)
'Tissue' Transglutaminase and Autoimmunity (Amendola, Piacentini)
Modification of RNA - Antigens in apoptosis (Utz)
THE ROLE OF DNA BINDING PROTEINS FOR SYSTEMIC AUTOIMMUNITY
Nucleosomes and anti-Nucleosome Autoantibodies as Mediators of Glomerular Pathology in Systemic Lupus Erythematosus (Dieker, van der Vlag Berden)
GLOSSARY
