Karlson Mechanisms of Hormone Action

A NATO Advanced Study Institute
1. Auflage 2013
ISBN: 978-1-4832-6762-3
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 288 Seiten, Web PDF

Mechanisms of Hormone Action: A NATO Advanced Study Institute focuses on the action mechanisms of hormones, including regulation of proteins, hormone actions, and biosynthesis. The selection first offers information on hormone action at the cell membrane and a new approach to the structure of polypeptides and proteins in biological systems, such as the membranes of cells. Discussions focus on the cell membrane as a possible locus for the hormone receptor; gaps in understanding of the molecular organization of the cell membrane; and a possible model of hormone action at the membrane level. The text also ponders on insulin and regulation of protein biosynthesis, including insulin and protein biosynthesis, insulin and nucleic acid metabolism, and proposal as to the mode of action of insulin in stimulating protein synthesis. The publication elaborates on the action of a neurohypophysial hormone in an elasmobranch fish; the effect of ecdysone on gene activity patterns in giant chromosomes; and action of ecdysone on RNA and protein metabolism in the blowfly, Calliphora erythrocephala. Topics include nature of the enzyme induction, ecdysone and RNA metabolism, and nature of the epidermis nuclear RNA fractions isolated by the Georgiev method. The selection is a valuable reference for readers interested in the mechanisms of hormone action.

Autoren/Hrsg.

Karlson, P.

Inhaltsverzeichnis

1;Front Cover;1
2;Mechanisms of Hormone Action: A Nato Advanced Study Institute;4
3;Copyright Page;5
4;Table of Contents;8
5;Preface;6
6;List of Contributors;10
7;List of Participants;12
8;PART 1: HORMONE ACTION BY CONTROL OF ENZYME ACTIVITY;14
8.1;Chapter 1. Zur Problemstellung und ihrer Entwicklung;14
8.1.1;Allgemeines über Hormonwirkungen (Stoffwechsel, Wachstum);15
8.1.2;Mögliche Arten der Wirkungsweise von Hormonen;15
8.1.3;Literatur;18
8.2;Chapter 2. Hormonwirkung als Enzymaktivierung;19
8.2.1;I. Thyreotropes Hormon;20
8.2.2;II. Adrenocorticotropes Hormon (ACTH);22
8.2.3;III. Gonadotrope Hormone (FSH/LH/HCG);23
8.2.4;IV. Adrenalin und Glucagon;26
8.2.5;V. Steroide;29
8.2.6;VI. Thyroxin;37
8.2.7;VII. Insulin;38
8.2.8;Summary;40
8.2.9;Literatur;41
8.3;Chapter 3. Les Protéines Allostériques et la Régulation Cellulaire;49
8.3.1;Bibliographie;49
8.4;Diskussion;50
9;PART 2: HORMONE ACTION BY CHANGES IN PERMEABILITY;54
9.1;Chapter 4. Die Permeabilität biologischer Membranen;54
9.1.1;Summary;69
9.1.2;Literatur;70
9.2;Diskussion;70
9.3;Chapter 5. Hormone Action at the Cell Membrane;74
9.3.1;Introduction;74
9.3.2;The Cell Membrane as a Possible Locus for the Hormone Receptor;75
9.3.3;Gaps in our Understanding of the Molecular Organization of the Cell Membrane;76
9.3.4;The Warner hexagonal conformation;79
9.3.5;A possible model of hormone action at the membrane level;89
9.3.6;Conclusion;94
9.3.7;Literature;95
9.4;Chapter 6. A New Approach to the Structure of Polypeptides and Proteins in Biological Systems such as the Membranes of Cells;96
9.4.1;Acknowledgement;102
9.4.2;Literature;102
9.5;Discussion;102
9.6;Chapter 7. Insulin;107
9.6.1;Literature;110
9.7;Chapter 8. Insulin and the Regulation of Protein Biosynthesis: Significance for Theories of the Hormones Mechanism of Action;111
9.7.1;Introduction;111
9.7.2;Relation of insulin action on protein synthesis to the action of the hormone on glucose transport;112
9.7.3;Insulin and protein biosynthesis;114
9.7.4;Possible mechanisms for the increase in protein synthesis mediated by insulin;118
9.7.5;Insulin and nucleic acid metabolism;119
9.7.6;Proposal as to the mode of action of insulin in stimulating protein synthesis;125
9.7.7;Acknowledgement;127
9.7.8;Bibliography;127
9.8;Diskussion;128
9.9;Chapter 9. Adiuretin;134
9.9.1;References;135
9.10;Diskussion;135
9.11;Chapter 10. The Action of a Neurohypophysial Hormone in an Elasmobranch Fish;142
9.11.1;References;143
9.12;Chapter 11. On the Mechanism of Action of the Parathyroid Hormone;144
9.12.1;Literature;150
10;PART 3: HORMONE ACTION BY GENE REGULATION AND ENZYME INDUCTION;152
10.1;Chapter 12. Hormonwirkung durch Genaktivierung;152
10.1.1;Literatur;154
10.2;Chapter 13. The Effect of Ecdysone on Gene Activity Patterns in Giant Chromosomes;155
10.2.1;Literature;158
10.3;Diskussion;158
10.4;Chapter 14. Action of Ecdysone on RNA and Protein Metabolism in the Blowfly, Calliphora erythrocephala;162
10.4.1;Nature of the enzyme induction;168
10.4.2;Ecdysone and RNA metabolism;169
10.4.3;Nature of the epidermis nuclear RNA fractions isolated by the Georgiev method;172
10.4.4;Time sequence of the events;175
10.4.5;References;176
10.5;Diskussion;177
10.6;Chapter 15. Some Studies on the Mode of Action of Erythropoietin;181
10.6.1;Literature;184
10.7;Diskussion;184
10.8;Chapter 16. Thyroid Hormones and Regulation of Protein Synthesis;186
10.8.1;Some basic considerations;187
10.8.2;Thyroid hormones and mitochondrial activity;187
10.8.3;Cytoplasmic protein synthesis;189
10.8.4;Nuclear regulation of protein synthesis;190
10.8.5;Integration of cellular actions;193
10.8.6;Developmental action of thyroid hormones;194
10.8.7;Conclusions;196
10.8.8;Literature;197
10.9;Chapter 17. Mechanism of Anabolic Action of Androgens;205
10.9.1;Anabolic action;205
10.9.2;Mechanism of action;209
10.9.3;Discussion;221
10.9.4;Summary;223
10.9.5;Literature;223
10.10;Diskussion;224
10.11;Chapter 18. Ribonucleic Acid and Protein Synthesis in Male Accessory Reproductive Glands and its Control by Testosterone;227
10.11.1;Levels and synthesis of RNA in rat prostate;229
10.11.2;Aminoacyl transfers by prostatic ribosomes;230
10.11.3;Template function of prostatic RNA in a bacterial ribosomal system;231
10.11.4;Remarks;232
10.11.5;Literature;234
10.12;Diskussion;234
10.13;Chapter 19. The Role of RNA and Protein Synthesis in Estrogen Action;241
10.13.1;References;251
10.14;Diskussion;252
10.15;Chapter 20. Studies on the Role of Hormonal Enzyme Induction in Glucocorticoid Action;259
10.15.1;Summary and Conclusions;269
10.15.2;Bibliography;270
10.16;Chapter 21. Changes in Alkaline Phosphatase and Arginase Activities Induced by Glucocorticoids;271
10.16.1;Results;271
10.16.2;References;275
10.17;Diskussion;275
10.18;Chapter 22. RNA Synthesis in Response to Steroid Hormones;282
10.18.1;Discussion;283
10.18.2;Literature;284
10.19;Diskussion;285