E-Book, Englisch, Band 1274, 260 Seiten, eBook
E-Book, Englisch, Band 1274, 260 Seiten, eBook
Reihe: Advances in Experimental Medicine and Biology
ISBN: 978-3-030-50621-6
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: Wasserzeichen (»Systemvoraussetzungen)
Recent studies of lipid metabolism expand the lipid biology field from
pro-inflammatory
lipid mediators to
anti-inflammatory
epoxy fatty acids (epoxyeicosatrienoic acids), and also omega-3 fatty acid-derived
pro-resolving
lipid mediators (lipoxin, resolvin, and neuroprotectin). These bioactive lipids, their metabolic pathways and receptors are of great interest in developing next-generation anti-inflammatory and pro-resolving drugs for a wide variety of diseases including.
This book summarizes not only historical overview of lipid signaling pathways but also provides summary of cutting-edge studies that may provide some hints of novel “druggable” lipid signaling targets.
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
Preface.- Introduction of Druggable Lipid Signaling Pathway.- Biosynthetic Enzymes of Membrane Glycerophospholipid Diversity as Therapeutic Targets for Drug Development.- Druggable Prostanoid Pathway.- Targeting Leukotrienes as a Therapeutic Strategy to Prevent Comorbidities Associated with Metabolic Stress.- Epoxy Fatty Acids are Promising Targets for Treatment of Pain, Cardiovascular Disease and Other Indications Characterized by Mitochondrial Dysfunction, Endoplasmic Stress and Inflammation.- Druggable Sphingolipid Pathway.- Druggable Lysophospholipid Pathway.- Druggable targets in endocannabinoid signaling.- Drugging the phosphoinositide 3-kinase (PI3K) and phosphatidylinositol 4-kinase (PI4K) family of enzymes for treatment of cancer, immune disorders, and viral/parasitic infections.- Druggable Lipid GPCRs: Past, Present, and Prospects.