Kolomeisky Motor Proteins and Molecular Motors

1. Auflage 2015
ISBN: 978-1-4822-2476-4
Verlag: Taylor & Francis
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 222 Seiten

A Unified Microscopic Approach to Analyzing Complex Processes in Molecular Motors

Motor Proteins and Molecular Motors explores the mechanisms of cellular functioning associated with several specific enzymatic molecules called motor proteins. Motor proteins, also known as molecular motors, play important roles in living systems by supporting cellular transport and force generation via the transformation of chemical energy into mechanical work.

The book presents established results, theoretical methods, and experimental observations related to biological molecular motors. It uses fundamental physical-chemical concepts and methods to develop a systematic theoretical framework for understanding motor protein dynamics. The author introduces the main ideas using simple arguments that avoid heavy mathematical derivations in favor of more intuitive physical understanding. Although the book assumes some rudimentary knowledge of cell biology, calculus, and basic ideas from chemistry and physics, it gives explanations and derivations for most results.

Accessible to students and researchers in a wide range of scientific fields, this book provides a unified molecular picture for analyzing motor proteins. It connects major experimental facts on molecular motors to principal theoretical concepts consistent with the fundamental laws of chemistry and physics.

Autoren/Hrsg.

Kolomeisky, Anatoly B.

Fachgebiete

• Naturwissenschaften Biowissenschaften Zellbiologie
• Naturwissenschaften Physik Physik Allgemein
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)

Inhaltsverzeichnis

Introduction

MOTOR PROTEINS IN BIOLOGICAL SYSTEMS

SINGLE-MOLECULE EXPERIMENTS

DISCUSSION OF THEORETICAL MODELS FOR MOLECULAR MOTORS

MOTOR PROTEINS AS NANOSCALE MACHINES

OUTLOOK

Basic Properties of Motor Proteins

HISTORY OF MOTOR PROTEINS

CLASSIFICATION OF BIOLOGICAL MOLECULAR MOTORS

STRUCTURES OF MOTOR PROTEINS

BIOLOGICAL FUNCTIONS OF MOLECULAR MOTORS
SUMMARY

Experimental Studies of Motor Proteins

INTRODUCTION

BULK CHEMICAL-KINETIC MEASUREMENTS

STRUCTURAL STUDIES

SINGLE-MOLECULE FORCE SPECTROSCOPY

FLUORESCENT LABELING AND SUPER-RESOLUTION TECHNIQUES

MAJOR EXPERIMENTAL OBSERVATIONS

SUMMARY

Fundamental Physical Concepts: Equilibrium Approaches

INTRODUCTION

BASIC EQUILIBRIUM THERMODYNAMICS

BASIC STATISTICAL MECHANICS

APPLICATION FOR MOTOR PROTEINS

SUMMARY

Fundamental Physical Concepts: Non-Equilibrium Approaches

INTRODUCTION

MACROSCOPIC CHEMICAL KINETICS

RANDOM WALKS

FIRST-PASSAGE PROCESSES

SUMMARY

MATHEMATICAL APPENDIX

Motor Proteins as Enzymes
INTRODUCTION

CATALYSIS

ENZYMATIC PROCESSES
SUMMARY

MATHEMATICAL APPENDIX

Theory for Motor Proteins: Continuum Ratchets

INTRODUCTION
CONTINUUM RATCHET POTENTIALS

CRITICAL ANALYSIS

SUMMARY

Theory for Motor Proteins: Discrete-State Stochastic Models

INTRODUCTION

DISCRETE-STATE STOCHASTIC APPROACH

CRITICAL ANALYSIS

SUMMARY

MATHEMATICAL APPENDIX

Collective Properties of Motor Proteins

COOPERATIVITY AND INTERACTIONS IN MOTOR PROTEINS DYNAMICS

EXPERIMENTAL OBSERVATIONS
THEORETICAL IDEAS

SUMMARY

Artificial Molecular Motors and Rotors

INTRODUCTION

BIOLOGICAL ARTIFICIAL MOLECULAR MOTORS
NON-BIOLOGICAL ARTIFICIAL MOLECULAR MOTORS
ARTIFICIAL MOLECULAR ROTORS

SUMMARY

Future Directions in Studies of Motor Proteins and Molecular Motors

WHAT WE UNDERSTAND NOW ABOUT MOTOR PROTEINS AND MOLECULAR MOTORS

OPEN QUESTIONS AND PROBLEMS

LOOKING INTO THE FUTURE

Index