Kriete / Eils Computational Systems Biology

From Molecular Mechanisms to Disease
2. Auflage 2013
ISBN: 978-0-12-405938-2
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, 548 Seiten

This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. - Logical information flow aids understanding of basic building blocks of life through disease phenotypes - Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns - Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation - Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.

Zielgruppe

Academic/professional/technical: Research and professional

Autoren/Hrsg.

Kriete, Andres

Eils, Roland

Leseproben

Contributors

Chapter 1

Roland Eils

Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany

Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany

Andres Kriete

School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA

Chapter 2

Robert B. Russell

Cell Networks, University of Heidelberg, Heidelberg, Germany

Gordana Apic

Cell Networks, University of Heidelberg, Heidelberg, Germany

Olga Kalinina

Cell Networks, University of Heidelberg, Heidelberg, Germany

Leonardo Trabuco

Cell Networks, University of Heidelberg, Heidelberg, Germany

Matthew J. Betts

Cell Networks, University of Heidelberg, Heidelberg, Germany

Qianhao Lu

Cell Networks, University of Heidelberg, Heidelberg, Germany

Chapter 3

Hans V. Westerhoff

Department of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands

Department of Molecular Cell Physiology, Faculty of Earth and Life Sciences, VU University Amsterdam, The Netherlands

Manchester Centre for Integrative Systems Biology (MCISB), Manchester, UK

Fei He

Manchester Centre for Integrative Systems Biology (MCISB), Manchester, UK

Department of Automatic Control and Systems Engineering, The University of Sheffield, Sheffield, UK

Ettore Murabito

Manchester Centre for Integrative Systems Biology (MCISB), Manchester, UK

Frédéric Crémazy

Department of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands

Matteo Barberis

Department of Synthetic Systems Biology and Nuclear Organization, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands

Chapter 4

Ursula Klingmüller

Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany

Marcel Schilling

Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany

Sonja Depner

Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany

Lorenza A. D’Alessandro

Division Systems Biology of Signal Transduction, German Cancer Research Center (DKFZ), Heidelberg, Germany

Chapter 5

Christina Kiel

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain

Universitat Pompeu Fabra (UPF), Barcelona, Spain

Luis Serrano

EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain

Universitat Pompeu Fabra (UPF), Barcelona, Spain

ICREA, Barcelona, Spain

Chapter 6

Seiya Imoto

Human Genome Center, Institute of Medical Science, The University of Tokyo, Minatoku, Tokyo, Japan

Hiroshi Matsuno

Faculty of Science, Yamaguchi University, Yoshida, Yamaguchi, Japan

Satoru Miyano

Human Genome Center, Institute of Medical Science, The University of Tokyo, Minatoku, Tokyo, Japan

Chapter 7

Hong-Wu Ma

Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, P.R. China

School of Informatics, University of Edinburgh, Edinburgh, UK

An-Ping Zeng

Institute of Bioprocess and Biosystems Engineering, Hamburg University of Technology, Denickestrasse, Germany

Chapter 8

Stanley Gu

Department of Bioengineering, University of Washington, Seattle, WA, USA

Herbert Sauro

Department of Bioengineering, University of Washington, Seattle, WA, USA

Chapter 9

Juergen Eils

Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany

Elena Herzog

Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany

Baerbel Felder

Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany

Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany

Christian Lawerenz

Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany

Roland Eils

Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany

Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany

Chapter 10

Jean-Christophe Leloup

Unité de Chronobiologie théorique, Faculté des Sciences, Université Libre de Bruxelles, Campus Plaine, Brussels, Belgium

Didier Gonze

Unité de Chronobiologie théorique, Faculté des Sciences, Université Libre de Bruxelles, Campus Plaine, Brussels, Belgium

Albert Goldbeter

Unité de Chronobiologie théorique, Faculté des Sciences, Université Libre de Bruxelles, Campus Plaine, Brussels, Belgium

Chapter 11

Reinhard Laubenbacher

Virginia Bioinformatics Institute, Virginia Tech, Blacksburg VA, USA

Pedro Mendes

Virginia Bioinformatics Institute, Virginia Tech, Blacksburg VA, USA

School of Computer Science, The University of Manchester, Manchester, UK

Chapter 12

Joseph Xu Zhou

Institute for Systems Biology, Seattle, WA, USA

Xiaojie Qiu

Institute for Systems Biology, Seattle, WA, USA

Aymeric Fouquier d’Herouel

Institute for Systems Biology, Seattle, WA, USA

Sui Huang

Institute for Systems Biology, Seattle, WA, USA

Chapter 13

John Cole

University of Illinois at Urbana-Champaign, USA

Mike J. Hallock

University of Illinois at Urbana-Champaign, USA

Piyush Labhsetwar

University of Illinois at Urbana-Champaign, USA

Joseph R. Peterson

University of Illinois at Urbana-Champaign, USA

John E. Stone

University of Illinois at Urbana-Champaign, USA

Zaida Luthey-Schulten

University of Illinois at Urbana-Champaign, USA

Chapter 14

Jean-Luc Bouchot

Department of Mathematics, Drexel University, PA, Philadelphia, USA

William L. Trimble

Institute for Genomics and Systems Biology, Argonne National Laboratory, University of Chicago, Chicago, IL, USA

Gregory Ditzler

Department of Electrical and Computer Engineering, Drexel University, PA, Philadelphia, USA

Yemin Lan

School of Biomedical Engineering, Science and Health, Drexel University, PA, Philadelphia, USA

Steve Essinger

Department of Electrical and Computer Engineering, Drexel University, PA, Philadelphia, USA

Gail Rosen

Department of Electrical and Computer Engineering, Drexel University, PA, Philadelphia, USA

Chapter 15

Helder I Nakaya

Department of Pathology, Emory University, Atlanta, GA, USA

Vaccine Research Center, Emory University, Atlanta, GA, USA

Department of Clinical Analyses and Toxicology, University of Sao Paulo, Sao Paulo, SP, Brazil

Chapter 16

Julien Delile

Institut des Systèmes...