Langley / Almarsson / Osborne The Pharmaceutical Applications of Dimethyl Sulfoxide

From Skin Penetration to Cell Therapy
Erscheinungsjahr 2026
ISBN: 978-3-032-19256-1
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 197 Seiten

Reihe: Biomedical and Life Sciences (R0)

This book provides an in-depth educational review of Dimethyl Sulfoxide (DMSO) and its utility in pharmaceutical drug development with specific focus on topical, parenteral, and biologics applications and formulations. Dimethyl sulfoxide is a widely used but often under-appreciated pharmaceutical material, which is perceived to be primarily confined to discovery research. This book helps to change this perception. This book brings current awareness of this multifunctional material as an API and excipient. This book also summarizes the safety and toxicology of dimethyl sulfoxide as it compares to other aprotic solvents. The intended audience is pharmaceutical scientists, pharmaceutical formulators, researchers, drug development professionals and academics.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Langley, Nigel

Almarsson, Örn

Osborne, David W.

Inhaltsverzeichnis

Introduction Scope of the book.- Physical and chemical properties of Dimethyl Sulfoxide.- Toxicology and Safety vs other aprotic solvents.- Skin Penetration enhancers in topical pharmaceutical drug development.- Skin penetration mechanism and mode of action of Dimethyl Sulfoxide.- Formulated topical drug products case studies.- Dimethyl Sulfoxide as an active pharmaceutical ingredient API.- Dimethyl Sulfoxide as a cryoprotectant.- Cell and Gene Therapy.- Subcutaneous delivery of highly concentrated and viscous biologics drugs.- Long Acting Injectable drug formulations.- mRNA vaccines.- Oral drug applications.

Über Autor(innen)

Nigel Langley is the Global Technical Director of  Gaylord Chemical Company LLC, which provides technical support to the pharmaceutical industry and helps solve drug formulation challenges. Prior to joining Gaylord Chemical, Nigel has held various senior technical and marketing positions with BASF and Croda International PLC. Nigel has also worked in Japan and England with Croda. He gained his Chemistry (Hons) degree and PhD (liquid crystals) from the University of Hull (UK) and an MBA from Leeds University (UK). He also took a 2- year Postdoctoral research position at Leeds University (UK) in natural product synthesis. He has over 100 scientific publications and has co- edited 2 books. Nigel is an adjunct professor at the University of Mississippi and a Fellow of the Royal Society of Chemistry (UK). In 2018 he was awarded the Industry Research Achievement Award in Excipient Technology by the IPEC Foundation. He has been a member of the Executive Committee at IPEC- Americas since 2010 and is currently Chair. Nigel is on the Medicine Maker’s Power List for 2020, 2021 & 2022.