Lankenau / Volff Transposons and the Dynamic Genome

1. Auflage 2009
ISBN: 978-3-642-02005-6
Verlag: Springer
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 184 Seiten

This volume gives an overview on mobile DNA and how such contradiction to the obligatory stability of genomes can be understood. Obviously, an understanding can only be achieved by cutting deeply into the evolutionary history of life.

Autoren/Hrsg.

Lankenau, Dirk-Henner

Volff, Jean-Nicolas

Inhaltsverzeichnis

1;Preface;6
2;Contents;14
3;Theoretical Approaches to the Dynamics of Transposable Elements in Genomes, Populations, and Species;17
3.1;1 Introduction;17
3.2;2 Genome Colonization;18
3.3;3 TE – Genome Coevolution;25
3.4;4 Conclusion;29
3.5;References;30
4;Infra- and Transspecific Clues to Understanding the Dynamics of Transposable Elements;36
4.1;1 Introduction;36
4.2;2 Lessons from the Past;38
4.3;3 Towards an Understanding of TE Regulation. From Sequence to Epigenetics;42
4.4;4 Conclusion;50
4.5;References;52
5;Morphological Characters from the Genome: SINE Insertion Polymorphism and Phylogenies;59
5.1;1 On the Importance of Getting the Phylogeny Right;59
5.2;2 SINEs;61
5.3;3 SINE Insertion Polymorphisms as Characters for Phylogeny;62
5.4;4 Methods;73
5.5;5 Conclusion;79
5.6;References;80
6;Genome Defense Against Transposable Elements and the Origins of Regulatory RNA;90
6.1;1 The Ascent of Regulatory RNA;90
6.2;2 RNAi and Genome Defense;92
6.3;3 TEs and microRNAs;94
6.4;4 Repeat-Associated Sequences and piRNAs;96
6.5;5 Transcript Infection Model;101
6.6;References;103
7;When Drosophila Meets Retrovirology: The gypsy Case;108
7.1;1 Introduction;108
7.2;2 Historical Background;110
7.3;3 Finding the Road to the Germline;111
7.4;4 Origin of the gypsy Env;112
7.5;5 Structural Analysis of gypsy Env;115
7.6;6 Functional Analysis of gypsy Env;116
7.7;7 Role of gypsy Env;116
7.8;8 Conclusion;117
7.9;References;118
8;Transposon–Host Cell Interactions in the Regulation of Sleeping Beauty Transposition;121
8.1;1 Introduction;122
8.2;2 The Sleeping Beauty Transposable Element: Structure and Mechanism of Transposition;122
8.3;3 Regulation of Transposition;123
8.4;4 Concluding Remarks;136
8.5;References;136
9;Interactions of Transposons with the Cellular DNA RepairMachinery;145
9.1;1 Introduction;146
9.2;2 The Types of DNA Damage Produced by Transposons;146
9.3;3 Cellular Processes Potentially Involved in Signaling and Repairing Transposition Intermediates;147
9.4;4 The Main Classes of Transposons;152
9.5;5 Repetitive Elements and Genome Stability;173
9.6;6 Transposition and Cell Cycle;175
9.7;7 Concluding Remarks;177
9.8;References;178
10;Subject Index;189