E-Book, Englisch, 230 Seiten, eBook
ISBN: 978-3-030-31897-0
Verlag: Springer International Publishing
Format: PDF
Kopierschutz: Wasserzeichen (»Systemvoraussetzungen)
Escherichia coli
,
Corynebacterium glutamicum
and yeast. It also discusses methodologies, such as bottom-up and top-down genome minimization strategies, as well as novel analytical and experimental approaches to characterize and generate minimal cells. Lastly, it presents the latest research related to minimal cells of serveral microorganisms, e.g.
Bacillus subtilis
.
The design of biological systems for biotechnological purposes employs strategies aimed at optimizing specific tasks. This approach is based on enhancing certain biological functions while reducing other capacities that are not required or that could be detrimental to the desired objective. A highly optimized cell factory would be expected to have only the capacity for reproduction and for performing the expected task. Such a hypothetical organism would be considered a minimal cell. At present, numerous research groups in academia and industry are exploring the theoretical and practical implications of constructing and using minimal cells and are providing valuable fundamental insights into the characteristics of minimal genomes, leading to an understanding of the essential gene set. In addition, research in this field is providing valuable information on the physiology of minimal cells and their utilization as a biological chassis to which useful biotechnological functions can be added.
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
Reduced and Minimal Cell Factories in Bioprocesses: Towards a Streamlined Chassis.- Construction of minimal genomes and synthetic cells.- Engineering reduced-genome strains of
Pseudomonas putida
for product valorization.- Genome-reduced
Corynebacterium glutamicum
fit for biotechnological applications.- Reduction of the
Saccharomyces cerevisiae
genome: challenges and perspectives.- The use of
in silico
genome-scale models for the rational design of minimal cells.- From minimal to minimized genomes: Functional design of microbial cell factories.- Resource allocation principles and minimal cell design.