Larson Bioinformatics and Drug Discovery

2. Auflage 2012
ISBN: 978-1-61779-965-5
Verlag: Humana Press
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 910, 374 Seiten, eBook

Reihe: Methods in Molecular Biology

Recent advances in drug discovery have been rapid.  The second edition of  Bioinformatics and Drug Discovery hasbeen completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter,  detailed procedures related to the use of these technologies and software have been incorporated. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

Thorough and intuitive, Bioinformatics and Drug Discovery, Second Edition  seeks to aid scientists in the further study of the rapidly expanding field of drug discovery.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Larson, Richard S.

Inhaltsverzeichnis

1. Cell Perturbation Screens for Target Identification by RNAi Kubilay Demir and Michael Boutros 2. Using Functional Genomics to Identify Drug Targets: a Dupuytren’s Disease ExampleMirela Sedic, Sandra Kraljevic Pavelic, Karlo Hock 3. Functional Characterization of Human Genes from Exon Expression and RNA Interference ResultsDorothea Emig, Hagen Blankenburg, Fidel Ramírez, and Mario Albrecht 4. Barcode Sequencing for Understanding Drug-gene InteractionsAndrew M. Smith, Tanja Durbic, Saranya Kittanakom, Guri Giaever, Corey Nislow 5. High-Throughput Sequencing of the Methylome Using Two-Base EncodingChristina A. Bormann Chung 6. Applications and Limitations of In Silico Models In Drug DiscoveryAhmet Secan, Sean Ekins, and Sandhya Kortagere 7. Compound Collection Preparation for Virtual ScreeningCristian G. Bologa and Tudor I. Oprea 8. Mapping Between Databases of Compounds and Protein TargestSorel Muresan, Markus Sitzmann, and Christopher Southan 9. Predictive Cheminformatics in Drug Discovery: Statistical Modeling for Analysis of Micro-Array and Gene Expression DataN. Sukumar, Michael P. Krein, Mark J. Embrechts 10. Advances in Nuclear Magnetic Resonance for Drug DiscoveryLaurel O. Sillerud, and Richard S. Larson 11. Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug ResistanceToshihisa Ishikawa, Hikaru Saito, Hiroyuki Hirano, Yutaka Inoue, Yoji Ikegami 12. Protein Interactions: Mapping Interactome Networks to Support Drug Target Discovery and SelectionJavier De Las Rivas and Carlos Prieto 13. Linking Variants from Genome-Wide Association Analysis to Function via Transcriptional Network AnalysisBenjamin J. Keller, Sebastian Martini, Viji Nair 14. Models of Excitation-Contraction Coupling in Cardiac Ventricular MyocytesM. Saleet Jafri 15. Integration of Multiple Ubiquitin Signals in Proteasome RegulationMarta Isasa, Alice Zuin and Bernat Crosas  4. Barcode Sequencing for Understanding Drug-gene InteractionsAndrew M. Smith, Tanja Durbic, Saranya Kittanakom, Guri Giaever, Corey Nislow 5. High-Throughput Sequencing of the Methylome Using Two-Base EncodingChristina A. Bormann Chung 6. Applications and Limitations of In Silico Models In Drug DiscoveryAhmet Secan, Sean Ekins, and Sandhya Kortagere 7. Compound Collection Preparation for Virtual ScreeningCristian G. Bologa and Tudor I. Oprea 8. Mapping Between Databases of Compounds and Protein TargestSorel Muresan, Markus Sitzmann, and Christopher Southan 9. Predictive Cheminformatics in Drug Discovery: Statistical Modeling for Analysis of Micro-Array and Gene Expression DataN. Sukumar, Michael P. Krein, Mark J. Embrechts 10. Advances in Nuclear Magnetic Resonance for Drug DiscoveryLaurel O. Sillerud, and Richard S. Larson 11. Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug ResistanceToshihisa Ishikawa, Hikaru Saito, Hiroyuki Hirano, Yutaka Inoue, Yoji Ikegami 12. Protein Interactions: Mapping Interactome Networks to Support Drug Target Discovery and SelectionJavier De Las Rivas and Carlos Prieto 13. Linking Variants from Genome-Wide Association Analysis to Function via Transcriptional Network AnalysisBenjamin J. Keller, Sebastian Martini, Viji Nair 14. Models of Excitation-Contraction Coupling in Cardiac Ventricular MyocytesM. Saleet Jafri 15. Integration of Multiple Ubiquitin Signals in Proteasome RegulationMarta Isasa, Alice Zuin and Bernat Crosas  10. Advances in Nuclear Magnetic Resonance for Drug DiscoveryLaurel O. Sillerud, and Richard S. Larson 11. Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug ResistanceToshihisa Ishikawa, Hikaru Saito, Hiroyuki Hirano, Yutaka Inoue, Yoji Ikegami 12. Protein Interactions: Mapping Interactome Networks to Support Drug Target Discovery and SelectionJavier De Las Rivas and Carlos Prieto 13. Linking Variants from Genome-Wide Association Analysis to Function via Transcriptional Network AnalysisBenjamin J. Keller, Sebastian Martini, Viji Nair 14. Models of Excitation-Contraction Coupling in Cardiac Ventricular MyocytesM. Saleet Jafri 15. Integration of Multiple Ubiquitin Signals in Proteasome RegulationMarta Isasa, Alice Zuin and Bernat Crosas  12. Protein Interactions: Mapping Interactome Networks to Support Drug Target Discovery and SelectionJavier De Las Rivas and Carlos Prieto 13. Linking Variants from Genome-Wide Association Analysis to Function via Transcriptional Network AnalysisBenjamin J. Keller, Sebastian Martini, Viji Nair 14. Models of Excitation-Contraction Coupling in Cardiac Ventricular MyocytesM. Saleet Jafri 15. Integration of Multiple Ubiquitin Signals in Proteasome RegulationMarta Isasa, Alice Zuin and Bernat Crosas