Le Du / Legrand / Sirigu Introduction to biological crystallography

1. Auflage 2024
ISBN: 978-2-7598-3502-7
Verlag: De Gruyter
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 155 Seiten

In the living world, the mechanisms that make us breathe, digest, grow or move an arm involve molecules made up of thousands of atoms, called macromolecules. These macromolecules are constantly circulating, interacting and deforming. Visualising these macromolecules at the atomic level is a unique tool for understanding their function and for designing drugs, inhibitors or activators. When using the three-dimensional structure of a macromolecule, it is essential to keep a critical eye. To do this, we need to understand how the structure was obtained. X-ray crystallography is a historical method of using X-rays and crystals to determine the three-dimensional atomic structure of molecules. It is also the most widely used.
The main audience for this book is biological scientists, although it will appeal to anyone interested in structural biology. It introduces the different steps involved in biological crystallography, from crystallisation to the determination of the three-dimensional structure of a macromolecule.

Thanks to the videos available through the QR codes at the end of each chapter, sites normally closed to the public are opened up to offer you a unique journey to the heart of life.

Autoren/Hrsg.

Le Du, Marie-Hélène

Legrand, Pierre

Sirigu, Serena

Ravy, Sylvain

Fachgebiete

• Naturwissenschaften Chemie Physikalische Chemie Chemische Kristallographie

Über Autor(innen)

Contributor: Marie-Hélène Le Du Marie-Hélène LE DU est directrice de recherche CEA à l'Institut de biologie cellulaire intégrative (I2BC/CNRS) de l'Université Paris-Saclay. --- Contributor: Pierre Legrand Pierre Legrand est scientifique de ligne sur la ligne Proxima-1 et membre de Héliobioau Synchrotron SOLEIL. --- Contributor: Serena Sirigu Serena Sirigu est scientifique de ligne sur la ligne Proxima-2A et membre de Héliobioau Synchrotron SOLEIL. --- Contributor: Sylvain Ravy Directeur de recherche au CNRS, au Laboratoire de Physique des Solides(LPS/CNRS) de l’Université Paris-Saclay.