Lim / Armstrong / Pardo Pharmacology of Pain

Proceedings of the First International Pharmacological Meeting, Stockholm, 22-25 August, 1961
1. Auflage 2016
ISBN: 978-1-4831-5528-9
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 258 Seiten, Web PDF

Pharmacology of Pain, Volume 9 presents the proceedings of the 3rd International Pharmacological Meetings held in Sao Paulo in 1966. The book includes papers on the mediators of pain; proteolytic enzymes as mediators of pain; and desensitization with capsaicin and related acylamides as a tool for studying the function of pain receptors. The text also covers the sensitization of nociceptors by 5-hydroxytryptamine in man; the possible role of serotonin in affective component of pain behavioral reaction in the rat; and the use of pain induced functional impairment for assessing analgesic action. Papers on the clinical pharmacology of analgesics and analgesic antagonists; behavioral mechanisms of human pain; and central nervous mechanisms involved in pain and analgesia are also considered. The book further tackles the neuropharmacology of pain and analgesia; the interrelationship of cortical and subcortical pain systems; and the interaction of fast- and slow-conducting fiber systems involved in pain and analgesia.

Autoren/Hrsg.

Lim, R. K. S.

Armstrong, D.

Pardo, E. G.

Inhaltsverzeichnis

1;Front Cover;1
2;Pharmacology of Pain;4
3;Copyright Page;5
4;Table of Contents;6
5;LIST OF AUTHORS;8
6;CHAPTER 1.
INTRODUCTORY REMARKS;10
7;CHAPTER 2. MEDIATORS OF PAIN;12
7.1;METHODS FOR STUDYING PAIN PRODUCTION BY CHEMICAL AGENTS;13
7.2;RECORDING PAIN SENSATION;14
7.3;GRAPHIC RECORDING OF PAIN;14
7.4;APPLICATION OF CHEMICALS;14
7.5;CANTHARIDIN BLISTER TECHNIQUE;15
7.6;ENDOGENOUS CHEMICAL AGENTS IN THE PRODUCTION OF PAIN;17
7.7;PRODUCTION OF PAIN BY BODY FLUIDS;17
7.8;PAIN IN MYONECROSIS;19
7.9;RELEASE OF K+ FROM ERYTHROCYTES;21
7.10;PAIN PRODUCTION BY SKIN EXTRACTS;23
7.11;RELEASE OF 5-HT FROM BLOOD PLATELETS;25
7.12;LYSOSOMAL CATIONIC PROTEIN IN POLYMORPHONUCLEAR LEUCOCYTES;25
7.13;HISTAMINE;26
7.14;PLASMA KININS;27
7.15;URATE CRYSTALS AND ACUTE GOUTY ARTHRITIS;30
7.16;MIGRAINE;31
7.17;TISSUE DAMAGE;31
7.18;CONCLUSIONS;31
7.19;REFERENCES;31
8;CHAPTER 3. PROTEOLYTIC ENZYMES AS MEDIATORS OF PAIN;34
8.1;METHODS AND RESULTS;35
8.2;DISCUSSION;40
8.3;SUMMARY;41
8.4;REFERENCES;41
9;CHAPTER 4. DESENSITIZATION WITH CAPSAICIN AND RELATED ACYLAMIDES AS A TOOL FOR STUDYING THE FUNCTION OF PAIN RECEPTORS;42
9.1;THE DESENSITIZING EFFECT OF CAPSAICIN;42
9.2;ADAPTATION OF PAIN RECEPTORS;45
9.3;EFFECT OF CAPSAICIN DESENSITIZATION ON THE NEUROGENIC INFLAMMATION;48
9.4;EFFECT OF CAPSAICIN ON THE HYPOTHALAMIC HEAT RECEPTORS;60
9.5;REFERENCES;63
10;CHAPTER 5. SENSITIZATION OF NOCICEPTORS BY 5-HYDROXYTRYPTAMINE IN MAN;66
10.1;INTRODUCTORY CLINICAL REMARKS: SPONTANEOUS AND EXPERIMENTAL "VASCULAR PAIN";66
10.2;OCCASIONS FOR THE LIBERATION OF 5HT IN MAN;69
10.3;SEROTONIN RECEPTORS IN HUMAN VEINS;70
10.4;5HT HYPERALGESIA IN OTHER AREAS OF THE BODY;76
10.5;5HT HYPERALGESIA AND ALGOGENIC ACTION OF PYROGENS;78
10.6;POSSIBLE IMPLICATIONS OF 5HT IN CLINICAL PAINS;83
10.7;COMMENT;88
10.8;SUMMARY;92
10.9;REFERENCES;93
11;CHAPTER 6. THE POSSIBLE ROLE OF SEROTONIN IN AFFECTIVE COMPONENT OF PAIN BEHAVIOURAL REACTION IN THE RAT;96
11.1;PHARMACOLOGICAL CONTROL OF PAIN TRANSMISSION;99
11.2;PHARMACOLOGICAL CONTROL OF PAIN BEHAVIOURAL REACTIONS;104
11.3;SUMMARY AND CONCLUSION;104
11.4;REFERENCES;108
12;CHAPTER 7. THE USE OF PAIN INDUCED FUNCTIONAL IMPAIRMENT FOR ASSESSING ANALGESIC ACTION;110
12.1;METHOD;110
12.2;ACTION OF ACETYLSALICYLIC ACID ON PAIN INDUCED FUNCTIONAL IMPAIRMENT;113
12.3;ACTION OF OTHER ANALGESIC AGENTS;114
12.4;ACTION OF CNS STIMULANT AND DEPRESSANT DRUGS ON PAIN INDUCED FUNCTIONAL IMPAIRMENT;114
12.5;INFLUENCE OF CNS STIMULANT AND DEPRESSANT DRUGS ON ACETYLSALICYLIC ACID ACTION;115
12.6;COMMENTS;118
12.7;REFERENCES;119
13;CHAPTER 8. THE CLINICAL PHARMACOLOGY OF ANALGESICS AND ANALGESIC ANTAGONISTS;122
13.1;ANALGESIC MIXTURES;122
13.2;"APC" VERSUS ASPIRIN ALONE;123
13.3;PHENACETIN ACTIVITY NOT DEPENDENT ON ITS METABOLITE;126
13.4;NARCOTIC ANTAGONISTS AS ANALGESICS;127
13.5;THEORETICAL IMPLICATIONS;127
13.6;REFERENCES;128
14;CHAPTER 9. SOME BEHAVIORAL MECHANISMS OF HUMAN PAIN;130
14.1;PAIN RESPONSE PARAMETERS: PAIN THRESHOLD AND PAIN TOLERANCE;130
14.2;NADEQUACY OF EXPERIMENTAL AND CLINICAL PAIN CONCEPTS;132
14.3;RESPONSE PARAMETERS DEPEND UPON SITE AND MODE OF ACTION OF ANALGESIC;133
14.4;TWO NEW METHODS OF ANALGESIC EVALUATION;134
14.5;GENERAL CONCLUSIONS: EXPERIMENTAL DESIGN OF ANALGESIC TESTS IN MAN;136
14.6;REFERENCES;138
15;CHAPTER 10. CENTRAL NERVOUS MECHANISMS INVOLVED IN PAIN AND ANALGESIA;140
15.1;I. CLASSICAL KNOWLEDGE ON PAIN SENSATIONS AND THE CONDUCTION OF THE CORRESPONDING MESSAGES IN PERIPHERAL NERVES;140
15.2;II. ANATOMO-PHYSIOLOGY OF THE SOMATIC AFFERENT PATHWAYS;144
15.3;III. PATHWAYS AND CENTRAL STRUCTURES INVOLVED IN CONSCIOUS PERCEPTION OF NOCICEPTIVE MESSAGES;157
15.4;CONCLUDING REMARKS;164
15.5;ACKNOWLEDGEMENTS;172
15.6;REFERENCES;172
16;CHAPTER 11. NEUROPHARMACOLOGY OF PAIN AND ANALGESIA;178
16.1;THE "PAIN" RECEPTORS;178
16.2;SITE AND MODE OF ACTION OF ANALGESIC AGENTS;186
16.3;DISPERSION OF SOMESTHETIC PATHWAYS IN THE BRAIN STEM;197
16.4;CENTRAL AND PERIPHERAL MECHANISMS OF SENSITIZATION AND DISINHIBITION;203
16.5;CENTRAL NON-NARCOTIC ANTI-APPETITE ANALGESICS THAT ACT THROUGH INHIBITION?;205
16.6;CHEMICAL MEDIATION AND RECIPROCAL INNERVATION IN THE CENTRAL "PAIN" PATHWAYS;206
16.7;THE NATURE OF THE PAIN RESPONSE;209
16.8;ACKNOWLEDGEMENTS;213
16.9;REFERENCES;214
17;CHAPTER 12. INTERRELATIONSHIP OF CORTICAL AND SUBCORTICAL PAIN SYSTEMS;228
17.1;DICHOTOMY OF CENTRAL PAIN TRACTS (CORTICAL AND SUBCORTICAL);228
17.2;CORTICAL PAIN TRACT AND THE VENTROPOSTERIOR THALAMIC NUCLEUS (V.c.pc);228
17.3;MEDIAL SUBCORTICAL TRACT AND LIMITANS AND INTRALAMINAR NUCLEI;233
17.4;REFERENCES;237
18;CHAPTER 13. INTERACTION OF FAST- AND SLOW-CONDUCTING FIBER SYSTEMS INVOLVED IN PAIN AND ANALGESIA;240
18.1;THE NEED FOR A NEW THEORY;240
18.2;GATE CONTROL THEORY OF PAIN;242
18.3;THE MOTIVATIONAL DIMENSION OF PAIN;246
18.4;REFERENCES;249
19;INDEX;252