Lorenzo / Horowitz / Choi Osteoimmunology

Interactions of the Immune and Skeletal Systems
2. Auflage 2015
ISBN: 978-0-12-800627-6
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 376 Seiten

Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology. This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics. Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget's disease, the genetics of bone disease, and bone cancer metastasis. - Explains the intricate interaction between the immune system and bone - Features detailed discussions of the key cellular and molecular mechanisms governing the homeostasis of the individual systems - Facilitates greater understanding of osteoimmunologic networks, their environments, and how this understanding leads to better treatments for human diseases involving both systems

Autoren/Hrsg.

Lorenzo, Joseph

Horowitz, Mark

Choi, Yongwon

Takayanagi, Hiroshi

Schett, Georg

Leseproben

List of Contributors

Antonios O. Aliprantis MD, PhD,     Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

Sheila N. Bello-Irizarry PhD,     Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA

Ryan Berry PhD,     Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA

Karine Briot MD, PhD,     Department of Rheumatology, INSERM U1153, Paris Descartes University, Cochin Hospital, Paris, France

Julia F. Charles MD, PhD,     Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

Yongwon Choi PhD,     Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

John L. Daiss PhD,     Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA

Jean-Michel Dayer MD,     Faculty of Medicine, Centre Medical Universitaire, Geneva, Switzerland

Karen L. de Mesy Bentley BS, MS

Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester

Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA

Thomas A. Einhorn MD,     Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, MA, USA

Roberta Faccio PhD,     Department of Orthopedics, Washington University in St. Louis School of Medicine, Saint Louis, MO, USA

Jackie A. Fretz PhD,     Comparative Medicine and Molecular, Cellular and Developmental Biology, Yale School of Medicine, New Haven, CT, USA

Gustavo P. Garlet DDS, MS, PhD,     Department of Biological Sciences, School of Dentistry of Bauru, University of Sao Paulo, Bauru, Brazil

Louis C. Gerstenfeld PhD,     Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, MA, USA

Piet Geusens MD, PhD,     Department of Internal Medicine, Subdivision of Rheumatology, Maastricht University Medical Center, Maastricht, The Netherlands

Mary B. Goldring PhD,     The Hospital for Special Surgery and Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY, USA

Steven R. Goldring MD,     The Hospital for Special Surgery and Department of Medicine, Weill Cornell Medical College, New York, NY, USA

Ellen M. Gravallese MD,     Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, USA

Dana T. Graves DDS, DMSc,     Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA

Danka Grcevic MD, PhD,     Department of Physiology and Immunology, University of Zagreb School of Medicine, Zagreb, Croatia

Mark C. Horowitz PhD,     Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA

Masaru Ishii MD, PhD

Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University, Osaka

CREST, Japan Science and Technology Agency, Tokyo, Japan

Rayyan A. Kayal BDS, DSc,     Department of Periodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia

Junichi Kikuta MD, PhD

Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University, Osaka

CREST, Japan Science and Technology Agency, Tokyo, Japan

Anne Klibansky MD,     Department of Medicine, Neuroendocrinology, Massachusetts General Hospital, Boston, MA, USA

Natasa Kovacic MD, PhD,     Department of Anatomy, University of Zagreb School of Medicine, Zagreb, Croatia

Henry M. Kronenberg MD,     Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

Sun-Kyeong Lee PhD,     Department of Medicine, UCONN Center on Aging, University of Connecticut Health Center, Farmington, CT, USA

Joseph Lorenzo MD,     Department of Medicine and Orthopaedics, University of Connecticut Health Center, Farmington, CT, USA

Ormond MacDougald PhD,     Departments of Molecular and Integrative Physiology and Internal Medicine (Metabolism, Endocrinology & Diabetes Division), University of Michigan School of Medicine, Ann Arbor, MI, USA

T. John Martin MD, DSc

St. Vincent’s Institute of Medical Research, Fitzroy

Department of Medicine, St. Vincent’s Hospital, Melbourne, The University of Melbourne, Fitzroy, Victoria, Australia

Mary C. Nakamura MD

Department of Medicine, Division of Rheumatology, University of California, San Francisco

Arthritis/Immunology Section, Veterans Administration Medical Center, San Francisco, CA, USA

Mark S. Nanes MD, PhD

Veterans Affairs Medical Center and Division of Endocrinology, Metabolism, and Lipids

Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA

Erin Nevius PhD,     Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA

Kohei Nishitani MD, PhD,     Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA

Charles A. O’Brien PhD,     Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences; the Central Arkansas Veterans Healthcare System, Little Rock, AR, USA

Thomas Oates DMD, PhD,     Department of Periodontics, University of Texas Health Science Center, San Antonio, TX, USA

Josef Martin Penninger MD,     Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, Austria

João P. Pereira PhD,     Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA

Julian M.W. Quinn PhD,     The Garvan Institute, Darlinghurst, New South Wales, Australia

Matthew S. Rodeheffer PhD,     Comparative Medicine and Molecular, Cellular and Developmental Biology, Yale School of Medicine, New Haven, CT, USA

Garson David Roodman MD, PhD,     Division of Hematology Oncology, Indiana University School of Medicine, Indianapolis, IN, USA

Clifford J. Rosen MD,     The Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, ME, USA

Christian Roux MD, PhD,     Department of Rheumatology, INSERM U1153, Paris Descartes University, Cochin Hospital, Paris, France

Georg Schett MD,     Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany

Edward M. Schwarz PhD

Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester

Department of Pathology and...