Macheras / Iliadis Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics

Homogeneous and Heterogeneous Approaches
1. Auflage 2006
ISBN: 978-0-387-31910-0
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 444 Seiten, Web PDF

Reihe: Mathematics and Statistics

The state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods.

This timely and useful book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology.

Zielgruppe

Research

Autoren/Hrsg.

Macheras, Panos

Iliadis, Athanassios

Inhaltsverzeichnis

Basic Concepts.- The Geometry of Nature.- Diffusion and Kinetics.- Nonlinear Dynamics.- Modeling in Biopharmaceutics.- Drug Release.- Drug Dissolution.- Oral Drug Absorption.- Modeling in Pharmacokinetics.- Empirical Models.- Deterministic Compartmental Models.- Stochastic Compartmental Models.- Modeling in Pharmacodynamics.- Classical Pharmacodynamics.- Nonclassical Pharmacodynamics.