Buch, Englisch, 707 Seiten, Format (B × H): 178 mm x 257 mm, Gewicht: 1547 g
Buch, Englisch, 707 Seiten, Format (B × H): 178 mm x 257 mm, Gewicht: 1547 g
ISBN: 978-0-12-473335-0
Verlag: Elsevier Science
Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Zielgruppe
Researchers in Immunology, biochemistry, endocrinology, and medicine- especially those working in allergy research
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Contributors
Preface
Acknowledgments
Section One Development of Mast Cells and Basophils
Chapter 1 Regulation of Mast Cell and Basophil Development by Stem Cell Factor and Interleukin-3
Introduction
SCF, a Ligand for the c-kit Receptor
Multiple Effects of SCF in Mast Cell Biology
SCF can Regulate Mast Cell Function In Vitro and In Vivo
Interleukin-3
Using IL-3-/- Mice to Assess the Role of IL-3 in Mast Cell and Basophil Development
Summary
Acknowledgments
References
Chapter 2 Gain-of-function Mutations of c-kit in Human Diseases
Introduction
Loss-of-function Mutation of c-kit
Stomach Lesions of W/Wv and SI/SId Mice
Gain-of-function Mutation of c-kit in Mast Cell Neoplasms
Sporadic Gastrointestinal Stromal Turnouts
Familial GIST
Conclusion
References
Chapter 3 Modulation of Mast Cell Development from Embryonic Haematopoietic Progenitors by Eotaxin
Chemokines and Their Receptors Play Diverse Roles as Mediators of Inflammation
Chemokines Participate in Multiple Mast Cell and Basophil Functions
Chemokine Secretion by Mast Cells
Eotaxin
Results
Discussion
References
Chapter 4 Regulation and Dysregulation of Mast Cell Survival and Apoptosis
Introduction
Regulation of Mast Cell Survival and Apoptosis by Growth Factors
Regulation of Mast Cell Survival and Apoptosis by Death Receptors
Regulation of Mast Cell Survival and Apoptosis by Perforin, Nitric Oxide and Bacterial Toxins
Regulation of Mast Cell Survival and Apoptosis by Irradiation and Chemical Agents
Perspective: Apoptosis and Mast Cell Disease
References
Section Two Phenotypic and Ultrastructural Features of Mast Cells and Basophils
Chapter 5 Ultrastructural Features of Human Basophil and Mast Cell Secretory Function
Introduction
Mechanism(s) of Histamine and CLC-P Secretion from Human Basophils, of Histamine Secretion from Human Mast Cells In Vitro and of TNF-a and Chymase Secretion from Rat Peritoneal Cells
Histamine Secretion from Human Mast Cells In Vivo
Heparin Secretion from Human Mast Cells In Vitro
The Vesiculovacuolar Organelle, a New Endothelial Permeability Structure
Acknowledgments
References
Chapter 6 Human Dendritic Mast Cells
Introduction
The Morphology of Human Dendritic Mast Cells
Functional Aspects and Future Lines of Research
Concluding Remarks
References
Chapter 7 The Phenotypic Similarities and Differences between Human Basophils and Mast Cells
Introduction
Morphology
Membrane Receptors
Cytoplasmic Contents
Mast Cell Phenotypes in Tissues
The Involvement of Mast Cells and Basophils in Asthma and Drug Reactions
Acknowledgments
References
Chapter 8 Interactions between Nerves and Mast Cells in Amphibians
Introduction
Morphology of Frog Mast Cells
Frog Mast Cells and Peripheral Nervous System
Occurrence of Mast Cells in the Central and Peripheral Nervous Systems of Mammals
Concluding Remarks
References
Section Three Signal Transduction in Mast Cells and Basophils
Chapter 9 Sequential Protein Kinase Activation and the Regulation of Mast Cell Cytokine Production
Introduction
Signaling Through Mast Cell
