Michelson / Zeimal / Alexander Acetylcholine

An Approach to the Molecular Mechanism of Action
1. Auflage 2014
ISBN: 978-1-4831-4545-7
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 272 Seiten, Web PDF

Acetylcholine: An Approach to the Molecular Mechanism of Action is an in-depth study of neurotransmitter system, with much focus on acetylcholine and its action and the cholinergic synapse. The book, divided into seven chapters, covers the following topics: the function of the cholinergic synapse; the movement of ions across membranes; the excitatory postsynaptic potential; the nature of cholinoreceptors and cholinesterases; the structure of its active centers; and the pattern of arrangement of the receptors of the cholinoreceptive membrane. The book also covers the quantitative evaluation of the action of neurotransmitters; the reactive capacity of the acetylcholine molecule and its effects on nerve endings and nerve fibers; and the release of mediators and hormones. The text is recommended for those who specialize in the fields of biology, medicine, biochemistry, and pharmacology, especially those wish to study about the neurotransmitter system, cholinoreceptors, the cholinergic synapse, the acetylcholine, and its action.

Autoren/Hrsg.

Michelson, M. J.

Zeimal, E. V.

Alexander, P.

Bacq, Z. M.

Inhaltsverzeichnis

1;Front Cover;1
2;Acetylcholine: An approach to the molecular mechanism of action;4
3;Copyright Page;5
4;Dedication;6
5;Table of Contents;8
6;Foreword;10
7;Preface;12
8;Acknowledgements;18
9;CHAPTER 1. The Function of the Cholinergic Synapse;20
9.1;1.1. A General Scheme of Function of the Cholinergic Synapse;20
9.2;1.2. The Movement of Ions Across the Membrane;23
9.3;1.3. The Excitatory Postsynaptic Potential;26
9.4;1.4. The "Quantal" Character of Mediator Release;29
9.5;1.5. The Inhibitory Postsynaptic Potential;32
9.6;1.6. Hypotheses concerning the Mechanism of the Change in Permeability of the Postsynaptic Membrane under the Influence of the Mediator
;33
9.7;1.7. The Significance of Calcium in the Release of the Mediator by the Nerve Endings and in the Function of Other Cells
;36
9.8;1.8. Localization of Cholinoreceptors and of Acetylcholinesterase in the Synapse;38
9.9;1.9. Peculiarities of Chemical Transmission for Nerve Impulses in Various Synapses
;43
9.10;1.10. Distribution and Physiological Significance of Cholinergic Systems in the Animal Kingdom
;51
10;CHAPTER 2. The Nature of Cholinoreceptors and Cholinesterases and Methods of Study of their Chemical Structure
;56
10.1;2.1. Chemical Nature of the Cholinoreceptor;56
10.2;2.2. Difficulties in the Biochemical Isolation of the Cholinoreceptor;61
10.3;2.3. The Chemical-pharmacological Method;65
11;CHAPTER 3. The Quantitative Evaluation of the Action of Substances that Stimulate and Block the Cholinoreceptor
;68
11.1;3.1. Theory of Interaction of Substances with the Cholinoreceptor;68
11.2;3.2. Quantitative Evaluation of the Potency of Cholinomimetics and Cholinolytics;85
11.3;3.3. Difficulties in the Quantitative Evaluation of the Action of Substances on the Cholinoreceptor
;91
12;CHAPTER 4. The Reactive Capacity of the Acetylcholine Molecule and the Structure of the Active Centres of ChoHnoreceptors and Cholinesterases
;98
12.1;4.1. The Cationic "Head" of Acetylcholine and the Anionic Portions of the Cholinoreceptor and of Cholinesterase
;99
12.2;4.2. The Importance of the Position of the Cationic Head in the Molecule for the Interaction of a Substance with Cholinoreceptors and Cholinesterases
;108
12.3;4.3. The Esterophilic Portion of the Cholinoreceptor;115
12.4;4.4. Structure of the Esteratic Portion of Cholinesterases and the Mechanism of their Interaction with Substrates and Inhibitors
;124
12.5;4.5. The Hydrophobic Portions in the Region of the Active Centres of Cholinesterases and Cholinoreceptors
;127
12.6;4.6. Changes in Cholinoreceptors, Arising as a Result of Prolonged Interaction with Acetylcholine.Desensitization;141
13;CHAPTER 5. Patterns of Arrangement of Individual Receptors on the Cholinoreceptive Membrane
;150
13.1;5.1. Investigations on Skeletal Muscle;150
13.2;5.2. Investigation of the Pattern of Arrangement of Cholinoreceptors in other Test Objects;181
14;CHAPTER 6. Changes in the Pattern of Arrangement of Cholinoreceptors in the Process of Evolution;190
14.1;6.1. Research on Muscle;190
14.2;6.2. Study of the Pattern of Arrangement of Cholinoreceptors on the Membrane of Neurones of Gastropod Molluscs
;206
14.3;6.3. Possible Biological Significance of the Complexing of Individual Cholinoreceptors into Oligomeric Structures in the Course of Evolution
;216
15;CHAPTER 7. Non-Synaptic Cholinoreceptors;218
15.1;7.1. Non-synaptic Cholinoreceptors in Skeletal Muscle;218
15.2;7.2. Action of Acetylcholine on Nerve Endings and Nerve Fibres;220
15.3;7.3. Non-synaptic Cholinoreceptors of Nerve Cells;222
15.4;7.4. Effect of Acetylcholine on the Release of Mediators and Hormones;226
15.5;7.5. Non-specific Receptors or Acceptors of Acetylcholine;229
16;References;236
17;Author Index;262
18;Subject Index;270
19;Other Titles in the Division Modern Trends in Physiological Sciences;276