Nagata / Takeyasu Nuclear Dynamics

Molecular Biology and Visualization of the Nucleus
1. Auflage 2007
ISBN: 978-4-431-30130-1
Verlag: Springer Japan
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 279 Seiten

The nuclear structure is not always stable but varies from hour to hour. Thus, it is important to capture dynamic changes of the structure and function from the viewpoint of molecular dynamics. Using the latest visualizing techniques in combination with biochemical and molecular biological methods, researchers from a broad range of fields of knowledge, including chromosomal structure, nuclear transfer, RNA, nuclear membrane, transcription, and nuclear domain structures, provide an overview of the nuclear structure and current issues in nuclear dynamics. The dynamics of nuclear structures described in this book furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.

Autoren/Hrsg.

Nagata, K.

Takeyasu, K.

Inhaltsverzeichnis

1;Preface: Overview of Nuclear Organization and Nuclear Dynamics;5
2;Contents;10
3;1. Visual Biology of Nuclear Dynamics: From Micro- to Nano- dynamics of Nuclear Components;12
4;2 Nuclear Envelope: Nanoarray Responsive to Aldosterone;49
5;3. Mitotic Chromosome Segregation Control;66
6;4. Breakdown and Reformation of the Nuclear Envelope;99
7;5. Functional Organization and Dynamic Aspects of Nucleoli During the Cell Cycle;117
8;6. Dynamics, Roles, and Diseases of the Nuclear Membrane, Lamins, and Lamin- binding Proteins;133
9;7. Gene Selectors Consisting of DNA-Binding Proteins, Histones, and Histone- Binding Proteins Regulate the Three Major Stages of Gene Expression;154
10;8. Dynamic Chromatin Loops and the Regulation of Gene Expression;185
11;9. Nuclear Architecture: Topology and Function of Chromatin- and Non- Chromatin Nuclear Domains;204
12;10-1. Regulation of Chromatin Structure by Curved DNA: How Activator Binding Sites Become Accessible;234
13;10- 2. Actin- Related Proteins Involved in Nuclear and Chromatin Dynamics;246
14;10- 3. Effects of 5- Bromodeoxyuridine on Chromatin Structure;256
15;10- 4. Transcriptional Modulation by Nuclear Matrix Protein P13Q/ MAT3 Associated with MAR/ SAR;262
16;10- 5. Breaking and Tessellating the Contiguous Nuclear Genome;270
17;Perspective— toward understanding the in situ genome function;277
18;Index;283