Newton / Roberts Prostaglandins and Thromboxanes

Butterworths Monographs in Chemistry
1. Auflage 2016
ISBN: 978-1-4831-6109-9
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 156 Seiten, Web PDF

Prostaglandins and Thromboxanes explores the two members of the prostanoid class of fatty acid. This book attempts to thoroughly discuss the topic after collecting enough information through research in physical and biological sciences. As the title suggests, the book revolves around prostaglandins and thromboxanes. The book's first chapter contains a discussion on the subject's history, stating the year of discovery and crediting the scientist who coined the names. The chapter ends talking about the possible uses of prostaglandins and thromboxanes in the clinic. The chapters that follow discuss the two lipids' basic and advanced synthesis, pharmacology, biosynthesis, biological activity, chemical interconversions, and metabolism, along with its subtopics. The book will serve as an excellent reference for undergraduate and graduate students in the related field.

Autoren/Hrsg.

Newton, Roger F.

Roberts, Stanley M.

Inhaltsverzeichnis

1;Front Cover;1
2;Prostaglandins and Thromboxanes;4
3;Copyright Page;5
4;Table of Contents;10
5;Preface;6
6;Contributors;8
7;CHAPTER 1. History, nomenclature and potential uses of prostaglandins and thromboxanes in the clinic;14
7.1;History;14
7.2;Structures and nomenclature of prostaglandins;14
7.3;Occurrence;17
7.4;Biosynthesis and metabolism;17
7.5;Potential clinical uses;17
8;CHAPTER 2. Biosynthesis and metabolism of prostaglandins and thromboxanes;21
8.1;Introduction;21
8.2;Prostaglandin biosynthesis;22
8.3;Prostaglandin metabolism (see Figure 2.7);29
8.4;References;31
9;CHAPTER 3. Pharmacology of natural prostaglandins and analogues;32
9.1;Introduction;32
9.2;Mechanism of action of prostaglandins and thromboxanes;32
9.3;Therapeutic applications of prostaglandins;47
9.4;Further reading;48
9.5;References;49
10;CHAPTER 4. Synthesis of prostaglandins from polycyclic molecules;50
10.1;Introduction;50
10.2;Harvard synthesis;51
10.3;Glaxo synthesis;61
10.4;References;74
11;CHAPTER 5. Synthesis of prostaglandins involving conjugate addition to cyclopentenones;75
11.1;Introduction;75
11.2;Conjugate addition to 2,4-disubstituted cyclopentenones (see Figure 5.2);77
11.3;Prostaglandin synthesis by conjugate addition and enolate trapping;92
11.4;References;96
12;CHAPTER 6. Chemical interconversions of prostaglandins: synthesis of prostaglandins G2, H2, and I2;97
12.1;Introduction;97
12.2;Chemical interconversions of prostaglandins D, E and F;97
12.3;Chemical interconversions of prostaglandins A, B, C and E;99
12.4;Reduction of prostaglandins of the 2-series to prostaglandins of the 1-series;100
12.5;Synthesis of prostaglandins G2and H2;100
12.6;Synthesis of prostaglandin I2;101
12.7;References;102
13;CHAPTER 7. Synthesis of thromboxanes;103
13.1;Introduction;103
13.2;Synthesis of TXB2 from prostaglandins and prostaglandin precursors;104
13.3;Synthesis from carbohydrates;105
13.4;References;107
14;CHAPTER 8. Synthesis and biological activity of prostaglandin analogues bearing modified side chains;108
14.1;Introduction;108
14.2;Alkyl substituted analogues;108
14.3;Dehydro analogues;110
14.4;Aryloxy substituted analogues;111
14.5;Heteroatom substituted analogues;114
14.6;C-1 Modified analogues;115
14.7;Hybrid analogues;118
14.8;References;119
15;CHAPTER 9. Synthesis and biological activity of prostaglandin analogues with modified ring systems;120
15.1;Introduction;120
15.2;Incorporation of additional ring substituents;120
15.3;Deoxyprostaglandins;122
15.4;Additional fused rings;129
15.5;Replacement of the cyclopentane ring;131
15.6;Prostaglandin endoperoxide analogues;136
15.7;Prostaglandin h analogues;140
15.8;References;143
16;CHAPTER 10. Synthesis and biological activity of thromboxane A2 (TXA2) analogues;145
16.1;Introduction;145
16.2;TXA2 ether analogues;145
16.3;Carbocyclic TXA2 analogues;147
16.4;References;149
17;Index;150