Ouldridge Coarse-Grained Modelling of DNA and DNA Self-Assembly

1. Auflage 2012
ISBN: 978-3-642-30517-7
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 176 Seiten

Reihe: Springer Theses

This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker — the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.

Zielgruppe

Research

Autoren/Hrsg.

Ouldridge, Thomas E.

Inhaltsverzeichnis

A Novel DNA Model.- Methods.- Finite Size Effects.- Structural and Mechanical Properties of Model DNA.- Thermodynamic Properties of Model DNA.- Modelling DNA Tweezers.- Modelling a DNA Walker.