Oxidative Phosphorylation in Health and Disease

1. Auflage 2007
ISBN: 978-0-387-26992-4
Verlag: Springer-Verlag
Format: PDF
Kopierschutz: Wasserzeichen (»Systemvoraussetzungen)

E-Book, Englisch, 205 Seiten

Mitochondrial diseases are often hard to diagnose. From the time they were first researched without animal models, patients of mitochondrial diseases were of equal interest to both clinical and basic scientists. With the new research done, this book includes updates on the normal structure, function, and molecular biology of the mitochondrial respiratory chain, information on traditional diagnostical methodologies, and an overview of the diagnostic promise of new technologies. The hypermetabolism of Luft disease, although only seen twice, is also studied. There are critical reviews of symptoms and signs associated with syndromes, as well as updates on the genetic defects of either the mitochondrial or the nuclear genome responsible for many disorders.

Autoren/Hrsg.

Inhaltsverzeichnis

1;CONTENTS;5
2;EDITORS;8
3;CONTRIBUTORS;8
4;FOREWORD ;11
5;The Human OXPHOS System: Structure, Function and Physiology;13
6;Molecular Biology of the OXPHOS System;40
7;Clinical Diagnosis of Oxidative Phosphorylation Disorders;55
8;Contribution of Histopathological Examination to the Diagnosis of OXPHOS Disorders;65
9;Biochemical Diagnosis of OXPHOS Disorders;91
10;Mitochondrial DNA and OXPHOS Disorders;107
11;Nuclear DNA and Oxidative Phosphorylation;129
12;Cell Biological Consequences of OXPHOS Disorders;142
13;Animal Models of OXPHOS Disorders;161
14;Therapeutic Options in OXPHOS Disorders;182
15;Prenatal Diagnostics in Oxidative Phosphorylation Disorders;188
16;Future Developments in the Laboratory Diagnosis of OXPHOS Disorders;199
17;INDEX;212