Clinical Molecular Diagnostics

2. Auflage 2027
ISBN: 978-981-9228-82-9
Verlag: Springer

Medienkombination, Englisch, 1659 Seiten, Format (B × H): 155 mm x 235 mm

This book covers the discovery of molecular biomarkers, the development of laboratory testing techniques and their clinical applications, focusing on basic research to clinical practice. It introduces new and crucial knowledge and ethics of clinical molecular diagnosis. This book emphasizes the applications of clinical molecular diagnostic test on health management, especially from different diseased organs.

In this second edition, the contents are updated according to the rapid development of molecular detection and diagnostic technology. 10 chapters are added, such as CTC and ctDNA detection, description and verification of biological reference intervals, and molecular diagnosis in 4 more common clinical diseases. It lets readers to understand and realize precision healthcare.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Pan, Shiyang

Capoluongo, Ettore

Ferreira-Gonzalez, Andrea

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Onkologie, Krebsforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pathologie, Cytopathologie, Histopathologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Labormedizin

Inhaltsverzeichnis

Concepts.- Classification of molecular diagnostic methods.- Assay performance evaluation.- Molecular aspects: From early development to the human genome and .- Molecular Biomarkers—signals from diseased functional organ.- Novel biomarkers.- Precision medicine .- Biological reference .- Establishment of biological reference interval.- Verification of biological reference intervals.- Description of biological reference interval.- Next generation sequencing (NGS).- Digital PCR.- Biosensor .- Microfluidic chips.- Liquid biopsy.- Molecular targeted imaging.- Immunological disorders: allergic diseases, autoimmune disease.- Liver disease.- Pancreatic disease.- Kidney disorders.- Cardiovascular disease.- Inflammation.- Nutrition disease.- Metabolism disorders.- Homeostasis disorders.- Pregnancy related disorders.- Diabetes.- Bone diseases.- Malignant diseases: risk factors; development of tumors; markers of malignant diseases.- Ethics: informed consent, patient privacy.- Bioinformatics andStandardization.- Molecular diagnostic report .- Consultation of molecular diagnostic tests .- Factors connected with variations: Sampling, Physiologic factor, .- Drug .- Quality assurance and quality control.- INDEX.

Über Autor(innen)

Professor Shiyang Pan, chief physician, researcher and doctoral supervisor, is the former director of the Department of Laboratory Medicine in Nanjing Medical University (NJMU) and the First Affiliated Hospital of NJMU.

Prof. Ettore Capoluongo is Full Professor of Clinical Biochemistry and Clinical Molecular Biology at the Department of Excellence in Molecular Medicine and Medical Biotechnology, Federico II University, Naples, Italy.

Dr. Andrea Ferreira-Gonzalez is Professor with Tenure, Department of Pathology, Virginia Commonwealth University, USA