Piraino / Selimovic Diagnostic Devices with Microfluidics

1. Auflage 2017
ISBN: 978-1-4987-7294-5
Verlag: CRC Press
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 279 Seiten

Reihe: Devices, Circuits, and Systems

This book provides a current view of the research and commercial landscape of diagnostics devices, particularly those that utilize microscale technologies, intended for both patient and laboratory use. Common diagnostic devices that are based on microfluidic principles include glucose sensors for diabetic patients and over-the-counter pregnancy tests. Other diagnostic devices are being developed to quickly test a patient for bacterial and viral infections, and other diseases. The chapters, written by experts from around the world, discuss how to fabricate, apply, and market microfluidic diagnostic chips – for lab and at-home use. Most importantly, the book also contains a discussion of topics relevant to the private sector, including patient-focused, market-oriented development of diagnostics devices.

Autoren/Hrsg.

Piraino, Francesco

Selimovic, Šeila

Selimovic, Seila

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Medizintechnik, Biomedizintechnik, Medizinische Werkstoffe
• Technische Wissenschaften Sonstige Technologien | Angewandte Technik Medizintechnik, Biomedizintechnik
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Medizinische Biotechnologie
• Technische Wissenschaften Maschinenbau | Werkstoffkunde Technische Mechanik | Werkstoffkunde

Inhaltsverzeichnis

Table of Contents

Preface

Section 1: Microfluidic devices for diagnostics

Chapter 1: Handheld Microfluidics for Point-of-care In-vitro Diagnostics

Baichen Li, Zhenyu Li

Chapter 2: Body-worn MF diagnostic devices

Mary M. Rodgers, Vinay M. Pai, Richard S. Conroy

Chapter 3: The Fabrication and Applications of Paper-based microfluidics

Xuan Mu, Yu S. Zhang

Chapter 4: Printed wax-ink valves for multi-step assays in paper analytical devices

Jacqueline C. Linnes, Elizabeth Phillips

Chapter 5: Myco-fluidics: Miniaturization of Mycotoxin Analysis

Jonathan H. Loftus, Gregor S. Kijanka, Richard O’Kennedy

Chapter 6: Planar Differential Mobility Spectrometry (DMS) for Clinical Breath Diagnostics

Erkinjon G. Nazarov, Timothy Postlethwaite, Kenneth Markoski, Sophia Koo, Jeffrey T. Borenstein

Section 2: Applications in disease detection

Chapter 7: Rapid diagnosis of infectious diseases using advanced microfluidic systems

Hardik J. Pandya, Mohamed S. Draz, Majid E. Warkiani, Hadi Shafiee

Chapter 8: Microfluidics for Tuberculosis diagnosis: advances, scalability and challenges

Bhavna G. Gordhan, Bavesh D. Kana

Section 3: Practical aspects of developing a commercial diagnostic device

Chapter 9: Starting with the end-in-mind by developing diagnostics around user-needs

Mark D. Lim

Chapter 10: Incorporating the Needs of Users in the Development of Diagnostics for Global Health: A Framework and Two Case Studies

Jacqueline C. Linnes, Elizabeth Johansen, Ashok A. Kumar

Über Autor(innen)

Francesco Piraino is currently a Research Scientist at the Swiss Federal Institute of Technology in Lausanne (Switzerland). He uses microscale technologies to develop next generation microfluidic diagnostics platforms. Following his graduate studies in Biomedical Engineering at Politecnico di Milano (Italy) and at Harvard-MIT Division of Health Science & Technology (U.S.A.), he joined the Broad Institute of MIT and Harvard (U.S.A.) to develop devices for single-cell genomics. Dr. Piraino is a trained bioengineer who has also attended programs at the Universitat de Barcelona (Spain), at the City College of the City University of New York (U.S.A.), and at the Massachusetts Institute of Technology (U.S.A.). His research aims to solve problems at the intersection of biomedical engineering, diagnostics and biology. His research interests include biomaterials, regeneration, bone as well as cardiac tissue engineering.

Šeila Selimovic is a Program Director at the National Institutes of Health, the National Institute of Biomedical Imaging and Bioengineering, where she manages research projects in the areas of organs-on-a-chip and biosensors. Prior to her current position, she was selected as a Science and Technology Policy Fellow by the American Association for the Advancement of Science (AAAS) to serve at the U.S. Department of State, covering science diplomacy issues relating to energy security and innovation. She was also a Postdoctoral Research Fellow at Harvard Medical School and Brigham & Women’s Hospital in Boston, MA, where she focused on the development of microfluidic platforms for applications in biophysics and biological engineering, such as organ-on-a-chip and high-throughput stem cell screening. Dr. Selimovic’s research interests further include the physics of microscale flows, protein crystallization, colloidal suspensions, as well as rheology and microrheology. Dr. Selimovic earned her Ph.D. and M. Sc. degrees in Physics from Brandeis University, where she was a recipient of a 2-year NSF Traineeship (IGERT). She is a member of Sigma Xi.