Poulin / Wilson Integration in Respiratory Control

From Genes to Systems
1. Auflage 2007
ISBN: 978-0-387-73693-8
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 605, 542 Seiten

Reihe: Advances in Experimental Medicine and Biology

This volume comprises the proceedings of the 10th Oxford Conference held at Lake Louise, Alberta, Canada, in September, 2006. It contains the most up-to-date research in cardio-respiratory control and its content spans the disciplines of respiratory physiology, neurobiology, modeling, and biomedical engineering. The volume will be of interest to clinicians working with patients with breathing disorders.

Autoren/Hrsg.

Poulin, Marc

Wilson, Richard J. A.

Inhaltsverzeichnis

1;Preface;6
2;Conference Proceedings;8
3;The Xth Oxford Conference: International Organizing Committee;9
4;The Xth Oxford Conference: Local Organizing Committee;11
5;The Xth Oxford Conference: Young Investigator Awards Selection Committee;13
6;Acknowledgements;14
7;Past Oxford Conferences;17
8;Contents;19
9;Erratum;29
10;Historical and Future Perspectives of the Control of Breathing;30
10.1;History of Measuring O2 and CO2 Responses;31
10.2;J.S. Haldane and Some of His Contributions to Physiology;37
10.3;Control of the Exercise Hyperpnea: The Unanswered Question;44
11;Oxygen Sensing and the Carotid Body;50
11.1;A Peripheral Oxygen Sensor Provides Direct Activation of an Identified Respiratory CPG Neuron in Lymnaea;51
11.2;Environmental Hyperoxia and Development of Carotid Chemoafferent Function;56
11.3;HSP70 Reduces Chronic Hypoxia-Induced Neural Suppression via Regulating Expression of Syntaxin;61
11.4;Effect of Systemic Administration of the Nitric Oxide Synthase Inhibitor L- NMMA on the Human Ventilatory Response to Hypoxia;67
11.5;Effects of Volatile Anesthetics on Carotid Body Response to Hypoxia in Animals;72
11.6;Mutation of the von Hippel-Lindau Gene Alters Human Cardiopulmonary Physiology;77
11.7;Intravenous Endothelin-1 and Ventilatory Sensitivity to Hypoxia in Humans;83
11.8;Key Roles for AMP-activated Protein Kinase in the Function of the Carotid Body?;89
11.9;Stimulatory Actions of Pituitary Adenylate Cyclase- Activating Polypeptide ( PACAP) in Rat Carotid Glomus Cells;95
11.10;Post-hypoxic Unstable Breathing in the C57BL/ 6J Mouse: Effects of Acetazolamide;101
12;Respiratory Rhythm Generation;106
12.1;Catecholaminergic Modulation of the Respiratory Rhythm Generator in the Isolated Brainstem– Spinal Cord Preparation from Neonatal Rat;107
12.2;What Role Do Pacemakers Play in the Generation of Respiratory Rhythm?;112
12.3;Pre-Bötzinger Complex Neurokinin-1 Receptor Expressing Neurons in Primary Cell Culture;118
12.4;Belt-and-Suspenders as a Biological Design Principle;123
12.5;Two Modes of Respiratory Rhythm Generation in the Newborn Rat Brainstem- Spinal Cord Preparation;128
12.6;Possible Roles of the Weakly Inward Rectifying K+ Channel Kir4.1 ( KCNJ10) in the Pre- Bötzinger Complex;133
12.7;Contribution of Pacemaker Neurons to Respiratory Rhythms Generation in vitro;138
12.8;Emergent Bursting in Small Networks of Model Conditional Pacemakers in the pre- Bötzinger Complex;143
13;Genes and Development;149
13.1;Brain Nuclei Controlling the Spinal Respiratory Motoneurons in the Newborn Mouse;150
13.2;Superoxide Dismutase-1 Influences the Timing and Post- hypoxic Stability of Neonatal Breathing;156
13.3;Neurodevelopmental Abnormalities in the Brainstem of Prenatal Mice Lacking the Prader- Willi Syndrome Gene Necdin;162
13.4;Consequences of Prenatal Exposure to Diazepam on the Respiratory Parameters, Respiratory Network Activity and Gene Expression of a1 and a2 Subunits of GABAA Receptor in Newborn Rat;167
13.5;Modulation of Perinatal Respiratory Rhythm by GABAA- and Glycine Receptor-mediated Chloride Conductances;172
13.6;Laryngeal Stimulation by an Acid Solution in the Pre- term Lamb;177
13.7;Necdin Gene, Respiratory Disturbances and Prader- Willi Syndrome;182
14;Models of Gas Exchange;188
14.1;Quantitative Analysis of the Oxygen Transfer in the Human Acinus;189
14.2;Role of Diffusion Screening in Pulmonary Diseases;195
14.3;A dp/dt Method to Assess Dynamic Properties of Lung Mechanoreceptors;201
14.4;Pulmonary Gas Exchange in Anatomically- Based Models of the Lung;206
14.5;Multi-scale Models of the Lung Airways and Vascular System;212
14.6;Modeling Structure-Function Interdependence of Pulmonary Gas Exchange;217
15;Plasticity and Adaptation;223
15.1;Ventilatory Control during Intermittent High- Intensity Exercise in Humans;224
15.2;Exercise-induced Respiratory Muscle Work: Effects on Blood Flow, Fatigue and Performance;230
15.3;Phase Relations Between Rhythmical Movements and Breathing in Wind Instrument Players;234
15.4;The Effect of Two Different Intermittent Hypoxia Protocols on Ventilatory Responses to Hypoxia and Carbon Dioxide at Rest;239
15.5;Respiratory Long-Term Facilitation: Too Much or Too Little of a Good Thing?;245
15.6;Contribution of Endothelin-1 and Endothelin A and B Receptors to the Enhanced Carotid Body Chemosensory Responses Induced by Chronic Intermittent Hypoxia;249
15.7;Intermittent Hypoxia Induces Respiratory Long- Term Facilitation in Postnatal Rats;254
15.8;Respiratory Control, Respiratory Sensations and Cycling Endurance After Respiratory Muscle Endurance Training;260
15.9;Non-dimensional Quantification of the Interactions Between Hypoxia, Hypercapnia and Exercise on Ventilation in Humans;266
15.10;Elevated Body Temperature Exaggerates Laryngeal Chemoreflex Apnea in Decerebrate Piglets;270
16;Neuromodulation;276
16.1;Effects of Systemic Administration of Mirtazapine on Respiratory Muscle Activity in Sleeping Rats;277
16.2;Control of Genioglossus Muscle by Sleep State- Dependent Neuromodulators;282
16.3;Significance of Multiple Neurochemicals that Regulate Respiration;288
16.4;Disinhibition of the Dorsomedial Hypothalamus Increases the Frequency of Augmented Breaths in the Anesthetized Rat;294
16.5;Major Components of Endogenous Neurotransmission Underlying the Discharge Activity of Hypoglossal Motoneurons in vivo;299
17;Comparative Aspects;305
17.1;Control of Ventilation in Diving Birds;306
17.2;Evolutionary Trends in Respiratory Mechanisms;312
18;Central Chemosensitivity;318
18.1;A Computer Model of Mammalian Central CO2 Chemoreception;319
18.2;A Mathematical Model of pHi Regulation in Central CO2- Chemoreception;324
18.3;Plasticity in the Brain: Influence of Bilateral Carotid Body Resection (bCBR) on Central CO2 Sensitivity;330
18.4;Glial Modulation of CO2 Chemosensory Excitability in the Retrotrapezoid Nucleus of Rodents;335
18.5;The Carotid Chemoreceptors are a Major Determinant of Ventilatory CO2 Sensitivity and of PaCO2 During Eupneic Breathing;340
18.6;The Retrotrapezoid Nucleus and Central Chemoreception;345
18.7;The Chemosensitive Response of Neurons from the Locus Coeruleus ( LC) to Hypercapnic Acidosis with Clamped Intracellular pH;351
18.8;CO2-sensitivity of GABAergic Neurons in the Ventral Medullary Surface of GAD67-GFP Knock-in Neonatal Mice;356
18.9;Multiple Central Chemoreceptor Sites: Cell Types and Function in vivo;361
18.10;Intrinsic Chemosensitivity of Individual Nucleus Tractus Solitarius ( NTS) and Locus Coeruleus ( LC) Neurons from Neonatal Rats;366
18.11;Chemosensitive Neuronal Network Organization in the Ventral Medulla Analyzed by Dynamic Voltage- Imaging;371
19;Brainstem Mechanisms Underlying Cardio- Respiratory Control;376
19.1;The Effects of a Respiratory Acidosis on Human Heart Rate Variability;377
19.2;Neurokinin-1 Receptor Activation in the Bötzinger Complex Evokes Bradypnea and is Involved in Mediating the Hering- Breuer Reflex;382
19.3;Brainstem Catecholaminergic Neurons Modulate both Respiratory and Cardiovascular Function;387
19.4;Responses of Brainstem Respiratory Neurons to Activation of Midbrain Periaqueductal Gray in the Rat;393
19.5;Computational Model of TASK Channels and PKC- Pathway Dependent Serotonergic Modulatory Effects in Respiratory- Related Neurons;398
19.6;Modulation of Hering-Breuer Reflex by Ventrolateral Pons;403
19.7;Respiratory Network Complexity in Neonatal Rat in vivo and in vitro;409
20;Multifunctional and Reconfiguring Networks;415
20.1;Fast Oscillatory Rhythms in Inspiratory Motor Discharge: A Mathematical Model;416
20.2;Burst-to-Burst Variability in Respiratory Timing, Inspiratory- Phase Spectral Activity, and Inspiratory Neural Network Complexity in Urethane- Anesthetized C57BL/ 6 Mice in vivo;422
20.3;Effects of Hypercapnia on Non-nutritive Swallowing in Newborn Lambs;428
20.4;CPAP Inhibits Non-nutritive Swallowing Through Stimulation of Bronchopulmonary Receptors;433
20.5;Glutamatergic Neurotransmission is Not Essential for, but Plays a Modulatory Role in, the Production of Gasping in Arterially- Perfused Adult Rat;438
21;Clinical Perspectives: Modeling and Control of Breathing ( i. e., Sleep Apnea);443
21.1;Potential Mechanism for Transition Between Acute Hypercapnia During Sleep to Chronic Hypercapnia During Wakefulness in Obstructive Sleep Apnea;444
21.2;Biochemical Control of Airway Motor Neurons During Rapid Eye Movement Sleep;450
21.3;Prediction of Periodic Breathing at Altitude;455
21.4;A Negative Interaction Between Central and Peripheral Respiratory Chemoreceptors May Underlie Sleep- Induced Respiratory Instability: A Novel Hypothesis;460
21.5;Ventilatory Response to Hypercapnia in Pre- menopausal and Post- menopausal Women;465
21.6;Oxidative Stress Impairs Upper Airway Muscle Endurance in an Animal Model of Sleep- Disordered Breathing;471
21.7;Ventilatory and Blood Pressure Responses to Isocapnic Hypoxia in OSA Patients;476
21.8;Modeling of Sleep-Induced Changes in Airway Function: Implication for Nocturnal Worsening of Bronchial Asthma;482
21.9;The Effects of Wakefulness State on the Temporal Characteristics of Ventilatory Variables in Man;488
21.10;Cerebral Blood Flow and Ventilatory Sensitivity to CO2 Measured with the Modified Rebreathing Method;493
21.11;Naloxone Reversal of Opioid-Induced Respiratory Depression with Special Emphasis on the Partial Agonist/ Antagonist Buprenorphine;499
21.12;The Pulse Oxygen Saturation: Inspired Oxygen Pressure (SpO2:PIO2) Diagram: Application in the Ambulatory Assessment of Pulmonary Vascular Disease;505
21.13;Hypocapnia and Airway Resistance in Normal Humans;510
21.14;Disturbances of Breathing in Rett Syndrome: Results from Patients and Animal Models;516
21.15;NHE3 in the Human Brainstem: Implication for the Pathogenesis of the Sudden Infant Death Syndrome ( SIDS)?;521
21.16;The Ventilatory Response to Exercise Does Not Differ Between Obese Women With and Without Dyspnea on Exertion;527
22;Author Index;532
23;Subject Index;550