Reid / Campbell / Dodgson Biochemical Approaches to Cancer

1. Auflage 2013
ISBN: 978-1-4832-2527-2
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 212 Seiten, Web PDF

Biochemical Approaches to Cancer focuses on biochemical approaches to cancer and covers topics ranging from the nature of carcinogens and their interactions with cell constituents to tissue composition and metabolism as affected by neoplasia. The metabolism of carbohydrates, fatty acids, proteins, and nucleic acids is also discussed, along with biochemical pharmacology. Comprised of nine chapters, this book begins with an overview of the nature of cancer, which includes basic concepts and terminology, histology, and the use of electron microscopy to study cells. The reader is then introduced to various approaches to the cancer problem; the nature of carcinogens and interactions with cell constituents; and the effect of neoplasia on tissue composition and metabolism. Subsequent chapters deal with the metabolism of carbohydrates, fatty acids, proteins, and nucleic acids. The book also considers the 'control mechanisms' governing enzymic activities and their role in neoplastic transformation before concluding with an analysis of the biochemical pharmacology of anti-cancer drugs. This monograph will be useful to biochemists, oncologists, pharmacologists, research workers, and undergraduate or postgraduate students interested in the biochemistry of cancer.

Autoren/Hrsg.

Reid, Eric

Campbell, P. N.

Dodgson, K. S.

Inhaltsverzeichnis

1;Front Cover;1
2;Biochemical Approaches to Cancer;4
3;Copyright Page;5
4;Table of Contents;6
5;Preface;10
6;Chapter 1. The Nature of Cancer;14
6.1;Basic Concepts and Terminology;14
6.2;Histology;19
6.3;PLATE 1;21
6.4;PLATE 2;24
6.5;PLATE 3;29
6.6;Electron Microscopy;32
7;Chapter 2. Approaches to the Cancer Problem;36
7.1;Role of Different Disciplines;36
7.2;Theories of Carcinogenesis;37
7.3;Biochemistry and Cancer Research;40
7.4;Test Material;41
7.5;Baselines for Expressing Results;49
7.6;Delineation of Metabolic Derangements in Cancer;50
8;Chapter 3. Nature of Carcinogens and Interactions with Cell Constituents;56
8.1;Experimental Induction of Cancer;56
8.2;Specificity in Target and in Structure;61
8.3;Metabolic Transformations of Carcinogens;65
8.4;Reactivity of Carcinogens towards Tissue Constituents;68
9;Chapter 4. Tissue Composition and Metabolism as affected by Neoplasia;74
9.1;The Tumour-bearing Host;74
9.2;Tumours and Precancerous Tissues: Areas of Study;78
9.3;Various Tissues Constituent (other than enzymes);79
9.4;Various Enzymes;81
9.5;Lipid Levels and Phospholipid Metabolism;84
10;Chapter 5. Carbohydrate and Fatty Acid Metabolism;87
10.1;Catabolism of Carbohydrate via Pyruvate: Early Observations;87
10.2;Catabolism of Carbohydrate via Pyruvate: Newer Observations;91
10.3;Glycogen Metabolism and Gluconeogenesis;96
10.4;Pentose-phosphate Cycle;98
10.5;Levels and Metabolism of Nicotinamide-adenine Dinucleotides;100
10.6;Fatty Acid Metabolism;105
11;Chapter 6. Protein Metabolism;108
11.1;Protein and Amino-acid Levels;108
11.2;Sulphydryl Compounds;112
11.3;Catabolism;113
11.4;Amino-acid Supply;117
11.5;Protein Synthesis;120
12;Chapter 7. Nucleic-Acid Metabolism;125
12.1;DNA and Its Catabolism;125
12.2;5'-Deoxyribonucleotides;128
12.3;RNA and Its Catabolism;133
12.4;5'-Ribonucleotides;142
12.5;Nucleic-acid Synthesis;147
13;Chapter 8. Control Mechanisms;155
13.1;Metabolic Parameters in Relation to Tumour Development;155
13.2;Enzymic Aspects of Molecular Biology in Relation to Cancer;159
13.3;Genetic Aspects of Molecular Biology in Relation to Cancer;172
14;Chapter 9. Biochemical Pharmacology;181
14.1;Chemotherapeutic Agents;181
14.2;Tissue Metabolism in Relation to Drug Action;183
14.3;Drug Resistance;195
15;References;200
15.1;Books, Reviews and Symposia;200
15.2;Original Papers;203
16;Index;210