Riederer / Youdim Amine Oxidases and Their Impact on Neurobiology

Proceedings of the 4th International Amine Oxidases Workshop, Würzburg, Federal Republic of Germany, July 7–10, 1990
1990
ISBN: 978-3-7091-9113-2
Verlag: Springer Wien
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 32, 491 Seiten, eBook

Reihe: Journal of Neural Transmission, Supplementa

Zielgruppe

Research

Autoren/Hrsg.

Riederer, Peter

Youdim, Moussa B.H.

Inhaltsverzeichnis

The state of the art.- The interaction of transport mechanisms and intracellular enzymes in metabolizing systems.- In-vivo quantitative imaging of catecholaminergic nerve terminals in brain and peripheral organs using positron emission tomography (PET).- The mechanism of action of antidepressants revised.- Monoamine oxidase and its inhibitors.- The expression of human MAO-A and -B genes.- Molecular neuroanatomy of MAO-A and MAO-B.- Turnover of monoamine oxidase B (MAO-B) in pig brain by positron emission tomography using 11C-L-deprenyl.- Visualisation of brain monoamine oxidase B (MAO-B) in dementia of Alzheimer’s type by means of large cryosection autoradiography: a pilot study.- Immuno-fluorescence cytochemistry on thin frozen sections of human substantia nigra for staining of monoamine oxidase A and monoamine oxidase B: a pilot study.- Effect of selective and reversible MAO inhibitors on dopamine outflow in rat striatum: a microdialysis study.- In vivo studies on the effect of monoamine oxidase inhibitors on dopamine and serotonin metabolism in rat brain areas.- Some pharmacological implications of MAO-mediated deamination of branched aliphatic amines: 2-Propy1-1-aminopentane and N-(2-propylpentyl)glycinamide as valproic acid precursors.- [3H] Harman labels selectively and with high affinity the active site of monoamine oxidase (EC 1.4.3.4) subtype A (MAOA) in rat, marmoset, and pig.- Inhibition of MAO by substituted tryptamine analogues.- Ring-substituted analogues of tranylcypromine as monoamine oxidase inhibitors.- Recent studies on the MAO inhibitor phenelzine and its possible metabolites.- Stylbasole analogues of MPTP as monoamine oxidase (MAO) substrates.- MAO activity, metabolism and anticonvulsant activity of milacemide in rats and mice.- Kinetic evaluation of MAO-B-activity following oral administration of selegiline and desmethyl-selegiline in the rat.- Effect of selegiline and desmethylselegiline on cortical electric activity in rats.- An enzymatic method for detecting MAO-A and MAO-B inhibitors in plasma and its application in studies with reversible MAO-A selective inhibitors.- Serotonin and 5-hydroxyindoleacetic acid in plasma. Potential use as peripheral measures of MAO-A activity.- Role of monoamine oxidase A and B in the deamination of newly-formed dopamine in the rat kidney.- Monoamine oxidase activity in blood platelets of migraine patients.- Monoamine oxidase inhibition by moclobemide and 2-aminoethyl carboxamide derivatives: mode of action and kinetic characteristics.- Does moclobemide stimulate melatonin synthesis as the other selective MAO-A inhibitors do?.- Efficacy and safety of moclobemide compared with imipramine in the treatment of major depressive disorder. Double-blind Multicenter Study, Austria.- Psychometric alterations in treatment with MAO-A-inhibitor moclobemide.- Clinical, biochemical and psychometric findings with the new MAO-A-inhibitors moclobemide and brofaromine in patients with major depressive disorder.- Brofaromine (CGP 11 305 A): estimation of plasma concentrations by a biologic technique as compared to liquid chromatography.- A double-blind, placebo-controlled study of the tolerability and effects on platelet MAO-B activity of single oral doses of MDL 72.974A in normal volunteers.- MAO-B inhibition in rabbit tissues and in human platelets by Ro 19-6327 shows similar time course.- Oxidative stress and autooxidation.- Monoamine oxidase and the bioactivation of MPTP and related neurotoxins: relevance to “DATATOP”.- Monoamine oxidase and oxidative stress at dopaminergic synapses.- The role of monoamine oxidase, iron-melanin interaction, and intracellular calcium in Parkinson’s disease.- Oxidation of the indole nucleus of 5-hydroxytryptamine and formation of dimers in the presence of peroxidase and H2O2.- Reflection of changes in membrane constituents in various regions of Alzheimer brains to differential scanning thermograms.- Effects of L-Deprenyl and Amantadine in an MPTP-Model of Parkinsonism.- Diamine oxidase — semicarbazide sensitive amine oxidase — polyamine oxidase.- Some aspects of the pharmacology of semicarbazide-sensitive amine oxidases.- Intestinal diamine oxidases and enteral-induced histaminosis: studies on three prognostic variables in an epidemiological model.- Methylamine oxidase from Arthrobacter P1 as a prototype of eukaryotic plasma amine oxidase and diamine oxidase.- Chronic ethanol feeding and diamine oxidase activity in rat brain and liver.- Amine oxidase activities in chemically-induced mammary cancer in the rat.- Monoamine oxidase and semicarbazide-sensitive amine oxidase activities in bovine eye.- Cultured preadipocytes produce a semicarbazide-sensitive amine oxidase (SSAO) activity.- Semicarbazide-sensitive amine oxidase activity in rat aortic cultured smooth muscle cells.- Amine oxidase activities in bovine lung.- Mucosal mono- and polyamine oxidase activities in digestive tract are distributed complementary to diamine oxidase.- Does FAD-dependent polyamine oxidase contribute to the metabolism of milacemide?.- Behaviour and properties of catechol-0-methyltransferase from human placenta.- Monoclonal antibodies recognizing both soluble and membrane bound catechol-0-methyl-transferase.- Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues.- Effects of the COMT inhibitor, CGP 28014, on plasma homovanillic acid and 0-methylation of exogenous L-DOPA in the rat.- Effect of the new selective COMT inhibitor CGP 28 014 A on the formation of 3-0-methyldopa (30MD) in plasma of healthy subjects.- Uptake processes.- Oxidative deamination of noradrenaline in human blood vessels.- Modification of alpha-2 presynaptic receptor activity and catecholamine release following chronic MAO inhibition.- Biochemical characterization and purification of the neuronal sodium-dependent noradrenaline transporter.- The importance of plasma 3,4-dihydroxyphenylglycol (DOPEG) in analyses of the sympathetic nervous system in vivo.- The involvement of desipra-mine-sensitive processes in the extraction of various catecholamines from plasma in the anaesthetized rabbit.- Human Caki-1 cells are the first model for extraneuronal transport of noradrenaline (uptake2) which is based on a clonal cell line.- The synaptic noradrenaline concentration in humans as estimated from simultaneous measurements of plasma noradrenaline and dihydroxyphenylglycol (DOPEG).- Inhibition of MAO activity, 3H-imipramine binding, 3H-paroxetine binding and 3H-5-HT uptake by human cerebrospinal fluid.- ?2-Adrenoceptor responsivity in depression: effect of chronic treatment with moclobemide, a selective MAO-A-inhibitor, versus maprotiline.- Supersensitivity to catecholamines after inhibition of extraneuronal uptake (uptake2) or 0-methylation.- Sulfation.- Urinary dopamine sulfate: regulations and significance in neurological disorders.- Effect of adrenal-caudate transplantation on CSF levels of salsolinol sulfate in patients with Parkinson’s disease.