Robaire / Hales Advances in Male Mediated Developmental Toxicity

Erscheinungsjahr 2012
ISBN: 978-1-4419-9190-4
Verlag: Springer US
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 300 Seiten, Web PDF

Reihe: Advances in Experimental Medicine and Biology

Zielgruppe

Research

Autoren/Hrsg.

Robaire, Bernard

Hales, Barbara F.

Inhaltsverzeichnis

Gender-Specificity of Gamete Susceptibilities to Exposures.- 1. Female-Specific Reproductive Toxicities Following Preconception Exposure to Xenobiotics.- 2. Overview of Male Mediated Developmental Toxicity.- Exposures and Effects: Occupational and Environmental.- 3. Epidemiologic Evidence on Biological and Environmental Male Factors in Embryonic Loss.- 4. Mechanisms of Male Mediated Developmental Toxicity Induced by Lead.- 5. Paternal Exposure to Known Mutagens and Health of the Offspring:.- 6. FISH (Fluorescence In Situ Hybridization) to Detect Effects of Smoking, Caffeine, and Alcohol on Human Sperm Chromosomes.- Markers of Sperm Damage and Germ Line Genotoxicity.- 7. Sperm Nuclear DNA Damage in the Human.- 8. The Human Spermatozoon—Not Waving but Drowning.- 9. Model Systems for Studying Germ Cell Mutagens: From Flies to Mammals.- 10. Germline Mutation Induction at Mouse and Human Tandem Repeat DNA Loci.- 11. PAINT/DAPI Analysis of Mouse Zygotes to Detect Paternally Transmitted Chromosomal Aberrations.- Exposures and Effects: Causes of Cancer and Consequences of Treatment.- 12. Paternal Occupation and Childhood Cancer.- 13. Radiation and Malformations in a Murine Model.- 14. Mechanisms of Action of Cyclophosphamide as a Male-Mediated Developmental Toxicant.- 15. Chromosome Abnormalities in Human Sperm.- Pregnancy Outcome.- 16. Distinguishing between Fertilization Failure and Early Pregnancy Loss when Identifying Male-Mediated Adverse Pregnancy Outcomes.- 17. ICSI, Male Pronuclear Remodeling and Cell Cycle Checkpoints.- 18. Increased Incidence of Malformations in the Offspring of Male Mice Prenatally Exposed to Synthetic Estrogens.- Strategies for Prevention.- 19. Implications of Research in Male-Mediated Developmental Toxicity to Clinical Counsellors, Regulators,and Occupational Safety Officers.- 20. Restoration of Spermatogenesis after Exposure to Toxicants: Genetic Implications.- Future Directions.- 21. Epigenetics: Role of Germ Cell Imprinting.- 22. Efficiency and Safety of Animal Cloning.- Workshop Reports.- 23. Integrating New Tests of Sperm Genetic Integrity into Semen Analysis: Breakout Group Discussion.- 24. Risk Assessment.- 25. Study Designs for the Assessment of Male Mediated Developmental Toxicity.- 26. Translational Research in Male Mediated Developmental Toxicity.- 285.- 287.