Roberts / Scheinmann Chemistry, Biochemistry, and Pharmacological Activity of Prostanoids

Including the Proceedings of a Symposium on the Chemistry and Biochemistry of Prostanoids Held at The University of Salford, England, 10-14 July 1978
1. Auflage 2013
ISBN: 978-1-4831-4603-4
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 420 Seiten, Web PDF

Chemistry, Biochemistry, and Pharmacological Activity of Prostanoids contains the proceedings of a symposium on the Chemistry and Biochemistry of Prostanoids held at the University of Salford, England on July 10-14, 1978. Separating 29 papers of the symposium as chapters, this book begins with a description of prostanoids in health and disease and recent developments in the synthesis of antisecretory prostaglandins. Other topics discuss synthesis of some novel 11-deoxyprostaglandins; bicycles, tricycles and prostaglandin synthesis; chemical and biological studies on new prostanoids; and isolation and characterization of enzymes involved in prostaglandin biosynthesis. Structure activity relationships of prostaglandins and a biochemical background of caloric restriction therapy of obesity are also explained.

Autoren/Hrsg.

Roberts, Stanley M.

Scheinmann, Feodor

Inhaltsverzeichnis

1;Front Cover ;1
2;Chemistry, Biochemistry, and Pharmacological Activity of Prostanoids;4
3;Copyright Page;5
4;Table of Contents;6
5;Preface;10
6;CHAPTER 1. PROSTANOIDS IN HEALT HAND DISEASE;14
6.1;Natural Occurrence of Prostanoids;14
6.2;Release of Prostanoids from Tissues;14
6.3;Prostaglandin Biosynthesis;16
6.4;Contraception, Abortion and Parturition;24
6.5;Male Fertility;26
6.6;Ductus Arteriosus and Congenital Heart Disease;28
6.7;Platelet Aggregation and Thrombosis;28
6.8;Concluding Remarks;29
6.9;BIBLIOGRAPHY;29
7;CHAPTER 2. RECENT DEVELOPMENTS IN THE SYNTHESIS OF AMISECRETORY PROSTAGLANDINS;30
7.1;ACKNOWLEDGMENTS:;38
7.2;REFERENCES AND NOTES;38
8;CHAPTER 3. SYNTHESIS OF SOME NOVEL11-DEOXYPROSTAGLANDINS;40
8.1;ACKNOWLEDGMENTS;50
8.2;REFERENCES;50
9;CHAPTER 4. SYNTHESIS AND BRONCHIAL DILATOR ACTIVITY OF SOME NOVEL PROSTAGLANDIN ANALOGUES (1);52
9.1;ABSTRACT;52
9.2;INTRODUCTION;52
9.3;SYNTHESES AND STRUCTURE ACTIVITY RELATIONSHIPS;52
9.4;ACKNOWLEDGEMENTS;71
9.5;REFERENCES;71
10;CHAPTER 5. BICYCLES, TRICYCLES AND PROSTAGLANDIN SYNTHESIS;74
10.1;REFERENCES;87
11;CHAPTER 6. THE TOTAL SYNTHESIS OF (±) PROSTAGLANDIN Di;88
11.1;References;98
12;CHAPTER 7. CHEMICAL AND BIOLOGICAL STUDIES ON NEW PROSTANOIDS;100
12.1;Acknowledgements;;112
12.2;References;112
13;CHAPTER 8. A METHOD FOR THE INVERSION OF CONFIGURATION OF ALCOHOLS;113
13.1;SUMMARY;126
13.2;ACKNOWLEDGEMENT;126
13.3;REFERENCES;127
14;CHAPTER 9. THE SYNTHESIS OF COMPOUNDS FORMED IN THE ARACHIDONIC ACID CASCADE AND AGENTS WHICH MODULATE THEIR PRODUCTION;128
14.1;REFERENCES;133
15;CHAPTER 10. ON THE EXISTENCE OF etQj-OXY-11,15-DIHYDROXYPROSTA-Z.ia-DIENOIC ACID;135
15.1;ABSTRACT;135
15.2;INTRODUCTION;135
15.3;MATERIALS AND METHODS;136
15.4;RESULTS;138
15.5;DISCUSSION;149
15.6;REFERENCES;149
16;CHAPTER 10. NOVEL METABOLITES OF ARACfflDONIC ACID;151
16.1;ABSTRACT;151
16.2;INTRODUCTION;151
16.3;METHODS;151
16.4;RESULTS AND DISCUSSION;152
16.5;REFERENCES;161
17;CHAPTER 11. BICYCLO [3,2,0] KEPT AN-2-0NES; A PHOTOCHEMICAL ROUTE TO PROSTANOID SYNTHONS;162
17.1;1. Introduction;162
17.2;2. Photocycloaddition reactions5;162
17.3;Discussion;166
17.4;3. Transformation of the cycloadducts to prostanoid synthons5;168
17.5;Acknovledgements;172
17.6;References and Notes;172
18;CHAPTER 12. THE SYNTHESIS OF GYGLOPENTENOLONE PRECURSORS TO PROSTAGLANDINS FROM FURAN DERIVATIVES;174
18.1;ABSTRACT;174
18.2;INTRODUCTION;174
18.3;ACKNOWLEDGMENTS;182
18.4;REFERENCES;182
19;CHAPTER 13. A GENERAL SYNTHESIS OF THE PROSTAGLANDINS FROM BUTADIENE AND LEVULINIC ACID;184
19.1;REFERENCES;196
20;CHAPTER 14. A NEW STEREOSELECTIVE SYNTHESIS OF PROSTAGLANDINS;198
20.1;INTRODUCTION;198
20.2;SYNTHESIS OF 11-DE0XY-PGF2Q2a;199
20.3;STEREOSELECTIVE SYNTHESIS OF 11-DEOXY-PGEj^ AND 10-OXA-ll-DEOXY-PGE1;200
20.4;STEREOSELECTIVE SYNTHESIS OF VGF2a;203
20.5;ACKNOWLEDGMENT;205
20.6;REFERENCES;205
21;CHAPTER 15. BIOLOGICALLY ACTIVE 11-DEOXYPROSTAGLANDINS;207
21.1;SUMMARY;220
21.2;REFERENCES;222
22;CHAPTER 16. THROMBOXANE-LIKE ACTIVITY OF PROSTANOIDS WITH AROMATIC SUBSTITUENTS AT C16 AND C17;223
22.1;ABSTRACT;223
22.2;INTRODUCTION;223
22.3;METHODS;224
22.4;RESULTS AND DISCUSSION;225
22.5;REFERENCES;232
23;CHAPTER 17. BIOSYNTHESIS OF PROSTAGLAND INSAND THROMBOXANES;234
23.1;ABSTRACT;234
23.2;THROMBOXANES - DISCOVERY AND PROPERTIES;234
23.3;THROMBOXANE SYNTHASE;236
23.4;REGULATION OF PROSTAGLANDIN AND THROMBOXANE SYNTHESIS;239
23.5;ACKNOWLEDGEMENTS;243
23.6;REFERENCES;243
24;CHAPTER 18. ISOLATION AND ............... OF ENZYMES INVOLVED IN PROSTAGLANDIN BIOSYNTHESIS;246
24.1;REFERENCES;255
25;CHAPTER 19. 15-DEOXY-16-HYDROXYPROSTAGLANDINS SYNTHESIS AND BRONCHODILATOR ACTIVITY;256
25.1;Acknowledgments.;269
25.2;References;269
26;CHAPTER 20. PROSTACYCLIN FORMATION AND EFFECTS;271
26.1;PREGUES ORS AND INTERMEDIATES OF PROSTAGLANDINS;271
26.2;REFERENCES;279
27;CHAPTER 21. SYNTHESIS AND STEREOCHEMISTRY OF STABLE PROSTACYCLIN ANALOGS;287
27.1;INTRODUCTION;287
27.2;DISCUSSION;288
27.3;REFERENCES AND NOTES;297
28;CHAPTER 22. SYNTHESIS AND BIOLOGICAL PROPERTIES OF PROSTACYCLINS AND PROSTAGLANDIN ENDOPEROXIDE ANALOGS;299
28.1;INTRODUCTION;299
28.2;OXYGEN-CONTAINING PROSTACYCLINS;302
28.3;SULFUR-CONTAINING PROSTACYCLINS;308
28.4;FLUORINE-CONTAINING PROSTACYCLINS;315
28.5;BIOLOGICAL PROPERTIES OF PROSTACYCLINS;317
28.6;PROSTAGLANDIN ENDOPEROXIDE ANALOGS;321
28.7;REFERENCES;323
29;CHAPTER 23. THE 6(9)... CYCLASE PATHWAY OF PROSTAGLANDIN ENDOPEROXIDE METABOLISM;326
29.1;ACKNOWLEDGEMENTS;336
29.2;REFERENCES;336
30;CHAPTER 24. THE GASTRIC ANTISECRETORY PROPERTIES OF SOME PROSTAGLANDIN ANALOGUES;339
30.1;REFERENCES;357
31;CHAPTER 25. STRUCTURE-ACTIVITY RELATIONSHIPS OF PROSTAGLANDINS;359
31.1;ABSTRACT;359
31.2;REFERENCES;377
32;CHAPTER 26. THE CLEAVAGE OF SILYLOXY GROUPS BY BORON TRIFLUORIDE ETHERATE;378
32.1;References;382
33;CHAPTER 27. 15-DEOXY-16-HYDROXY-PGEi CARBINOLS SYNTHESIS AND BIOLOGICAL ACTIVITY;383
33.1;References;392
34;CHAPTER 28. A BIOCHEMICAL BACKGROUND OF CALORY RESTRICTION THERAPY OF OBESITY: LIPID PEROXIDE MOBILIZATION;393
35;CHAPTER 29. THE SYNTHESIS AND BIOLOGICAL PROPERTIES OF 9a, lla-TRITHIOGARBONATEOF 9, lla-BISDESOXY-PGFi.A MIMIG OF PROSTAGLANDINENDOPEROXIDES;394
35.1;ABSTRACT;394
35.2;EXPERIMENTAL SECTION;402
35.3;SUMMAHT;407
35.4;BIBLIOGRAPHY;408
36;AUTHOR INDEX;411
37;SUBJECT INDEX;413