Roth The Serotonin Receptors

From Molecular Pharmacology to Human Therapeutics
1. Auflage 2008
ISBN: 978-1-59745-080-5
Verlag: Humana Press
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 618 Seiten

Reihe: The Receptors

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

Autoren/Hrsg.

Roth, Bryan L.

Inhaltsverzeichnis

1;Preface;6
2;Contents;9
3;Contributors;12
4;Color Plate;16
5;Molecular Biology and Genomic Organization of G Protein– Coupled Serotonin Receptors;17
6;Structure and Function Reveal Insights in the Pharmacology of 5- HT Receptor Subtypes;55
7;Polymorphic and Posttranscriptional Modifications of 5- HT Receptor Structure;75
8;Strategies for the Development of Selective Serotonergic Agents;107
9;5-HT Receptor Signal Transduction Pathways;159
10;Agonist-Directed Trafficking of 5-HT Receptor- Mediated Signal Transduction;223
11;Identification of 5- HT2 and 5-HT4 Receptor- Interacting Proteins;252
12;5-HT Receptor-Associated Proteins (FRAPs);275
13;Cellular and Subcellular Localization of Serotonin Receptors in the Central Nervous System;295
14;Chemical Neuroanatomy of 5-HT Receptor Subtypes in the Mammalian Brain;336
15;Modulation of the Neuronal Activityand Neurotransmitter Release by 5-HT1Aand 5-HT1B/1D Receptors;382
16;Electrophysiology of 5- HT2A Receptors and Relevance for Hallucinogen and Atypical Antipsychotic Drug Actions;419
17;The Emergence of 5- HT2B Receptors as Targets to Avoid in Designing and Refining Pharmaceuticals;434
18;The 5- HT3 Receptor;454
19;5- HT3 and 5-HT4 Receptors as Targets for Drug Discovery for Dementia;473
20;Electrophysiological Propertiesof Gas-Coupled 5-HT Receptors(5-HT4, 5-HT6, 5-HT7);494
21;5- HT6 Receptors as Targets for the Treatment of Cognitive Deficits in Schizophrenia;508
22;5- HT7 Receptors as Favorable Pharmacological Targets for Drug Discovery;529
23;Serotonin System Gene Knockouts;548
24;Effects of Serotonin-Related Gene Deletion on Measures of Anxiety, Depression, and Neurotransmission;587
25;Index;617