Sadana Fractal Analysis of the Binding and Dissociation Kinetics for Different Analytes on Biosensor Surfaces

1. Auflage 2007
ISBN: 978-0-08-055501-0
Verlag: Elsevier Science & Techn.
Format: EPUB
Kopierschutz: 6 - ePub Watermark

E-Book, Englisch, 372 Seiten

Biosensors are finding increasing applications in different areas. Over the last few years the areas where biosensors may be used effectively has increased dramatically. This book like the previous four books on analyte-receptor binding and dissociation kinetics by this author addresses the often neglected area. The kinetics of binding and dissociation in solution to appropriate receptors immobilized on biosensor surfaces occurs under diffusional limitations on structured surfaces. The receptors immobilized on the biosensor surface contribute to the degree of heterogeneity on the sensor chip surface.
The fractal analysis examples presented throughout the book provide a convenient means to make quantitative the degree of heterogeneity present on the sensor surface, and relates it to the binding and dissociation rate coefficients. The fractal dimension is a quantitative measure of the degree of heterogeneity present on the biosensor surface. The book emphasizes medially-oriented examples. The detection of disease-related analytes is also emphasized. The intent being that if intractable and insidious diseases are detected earlier, they will be controlled better, eventually leading to a better prognosis. Chapter 3 is a new chapter that emphasizes enhancing the relevant biosensor performance parameters such as sensitivity, stability, selectivity, response time, etc.
As usual, as done in previous books by this author, the last chapter provides an update of the economics involved in biosensors, and the difficulties encounters in starting-up a biosensor company.
- Modelling of binding and dissociation kinetics of analyte-receptor reactions on biosensor surfaces: provides physical insights into these reactions occurring on biosensor surfaces. Very few researchers even attempt to analyze the kinetics of these types of reactions.
- Fractal analysis used to model the binding and dissociation kinetics: original and unique approach.
- Economic analysis provided in the last chapter: helps balance the book; besides providing much-needed information not available in the open literature.
- Emphasis on improving biosensor performance parameters: helps make biosensors better.
- Empahsis on medically-related analytes: helps in prognosis of diseases.

Autoren/Hrsg.

Sadana, Ajit

Sadana, Neeti

Inhaltsverzeichnis

1;Cover;1
2;Contents;6
3;Preface;10
4;Chapter 1. Introduction;12
4.1;Cost and Implications of Medical Care of Some Common Diseases;12
5;Chapter 2. Modeling and Theory;16
5.1;2.1 Introduction;16
5.2;2.2 Theory;19
6;Chapter 3. Biosensor Performance Parameters and their Enhancement;30
6.1;3.1 Introduction;30
6.2;3.2 Theory;32
6.3;3.3 Results;34
6.4;3.4 Conclusions;62
7;Chapter 4. Fractal Analysis of Harmful Bacteria, Toxins, and Pathogen Detection on Biosensor Surfaces;66
7.1;4.1 Introduction;66
7.2;4.2 Theory;67
7.3;4.3 Results;69
7.4;4.4 Conclusions;97
8;Chapter 5. Fractal Binding and Dissociation Kinetics of Disease-Related Compounds on Biosensor Surfaces;100
8.1;5.1 Introduction;100
8.2;5.2 Theory;101
8.3;5.3 Results;103
8.4;5.4 Conclusions;129
9;Chapter 6. Fractal Analysis of Binding and Dissociation of Analytes that Help Control Diseases on Biosensor Surfaces;134
9.1;6.1 Introduction;134
9.2;6.2 Theory;135
9.3;6.3 Results;137
9.4;6.4 Conclusions;158
10;Chapter 7. Fractal Analysis of Binding and Dissociation of Small Molecules Involved in Drug Discovery on Biosensor Surfaces;162
10.1;7.1 Introduction;162
10.2;7.2 Theory;163
10.3;7.3 Results;165
10.4;7.4 Conclusions;192
11;Chapter 8. Fractal Binding and Dissociation Kinetics of Prion-Related Interactions on Biosensor Surfaces;196
11.1;8.1 Introduction;196
11.2;8.2 Theory;197
11.3;8.3 Results;198
11.4;8.4 Conclusions;207
12;Chapter 9. Fractal Analysis of Binding and Dissociation of DNA–Analyte Interactions on Biosensor Surfaces;210
12.1;9.1 Introduction;210
12.2;9.2 Theory;211
12.3;9.3 Results;213
12.4;9.4 Conclusions;236
13;Chapter 10. Fractal Analysis of Binding and Dissociation of Protein–Analyte Interactions on Biosensor Surfaces;240
13.1;10.1 Introduction;240
13.2;10.2 Theory;241
13.3;10.3 Results;243
13.4;10.4 Conclusions;266
14;Chapter 11. Fractal Analysis of Different Compounds Binding and Dissociation Kinetics on Biosensor Surfaces;270
14.1;11.1 Introduction;270
14.2;11.2 Theory;271
14.3;11.3 Results;273
14.4;11.4 Conclusions;303
15;Chapter 12. Fractal Analysis of Binding and Dissociation Kinetics of Environmental Contaminants and Explosives on Biosensor Surfaces;308
15.1;12.1 Introduction;308
15.2;12.2 Theory;309
15.3;12.3 Results;310
15.4;12.4 Conclusions;323
16;Chapter 13. Market Size and Economics for Biosensors;328
16.1;13.1 Introduction;328
16.2;13.2 Collaboration Between Companies, Universities, and State and Governmental Agencies: Trends in Collaboration;331
16.3;13.3 Factors that Could help Increase/Decrease Biosensor Markets;333
16.4;13.4 Examples of Biosensor Companies, their Product, and their Financial Backers;335
16.5;13.5 Conclusions;342
17;Index;346