Saltiel / Pessin Mechanisms of Insulin Action

1. Auflage 2007
ISBN: 978-0-387-72204-7
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 214 Seiten

Reihe: Medical Intelligence Unit

More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.

Autoren/Hrsg.

Saltiel, Alan R.

Pessin, Jeffrey E.

Inhaltsverzeichnis

1;PREFACE;10
2;1 Insulin and IGF-I Receptor Structure and Binding Mechanism;11
3;2 Subcellular Compartmentalization of Insulin Signaling Processes and GLUT4 TrajflScking Events;43
4;3 Regulation of Insulin Action and Insulin Secretion by SNARE- Mediated Vesicle Exocytosis;62
5;4 Control of Protein Synthesis by Insulin;81
6;5 Hepatic Regulation of Fuel Metabolism;100
7;6 Insulin Action Gene Regulation;120
8;7 Insulin Action in the Islet p-Cell;143
9;8 Central Regulation of Insulin Sensitivity;162
10;9 Transgenic Models of Impaired Insulin Signaling;178
11;10 Insulin Resistance;195
12;Index;220