Savagner Rise and Fall of Epithelial Phenotype

Concepts of Epithelial-Mesenchymal Transition
1. Auflage 2007
ISBN: 978-0-387-28671-6
Verlag: Springer-Verlag
Format: PDF
Kopierschutz: Wasserzeichen (»Systemvoraussetzungen)

E-Book, Englisch, 248 Seiten

Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT). The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.

Autoren/Hrsg.

Savagner, Pierre

Inhaltsverzeichnis

1;CONTENTS;5
2;EDITOR;10
3;CONTRIBUTORS;10
4;PREFACE;15
5;EMT Concept and Examples from the Vertebrate Embryo;20
6;Epithelium- Mesenchyme Transitions Are Crucial Morphogenetic Events Occurring during Early Development;31
7;The Neural Crest: A Model Developmental EMT;48
8;Epithelial-Mesenchymal Transfonnation in the Embryonic Heart;59
9;Epithelial- Extracellular Matrix (Cell-ECM) Interactions in Hydra;75
10;Regulation of the Epithelial-to-Mesenchymal Transition in Sea Urchin Embryos;96
11;Change of Epithelial Fate: Lessons from Gastnilation in Drosophila;120
12;Cutaneous Wound Reepithelialization: A Partial and Reversible EMT;130
13;Epithelial-Mesenchymal Transitions in Human Cancer;154
14;Structural and Functional Regulation of Desmosomes;179
15;Epithelial Cell Plasticity by Dynamic Transcriptional Regulation of E- Cadherin;197
16;The Regulation of Catenins in Cancer;210
17;Hepatocyte Growth Factor Regulates Transitions between Epithelial and Mesenchymal Cellular Phenotypes during Normal Development and in Disease;222
18;The Role of Insulin-Like Growth Factors in the Epithelial to Mesenchymal Transition;234
19;TGFb 3- Dependent Epithelial-Mesenchymal Transition;255
20;The Ras and Src Signaling Cascades Involved in Epithelial Cell Scattering;264
21;Regulation of E-Cadherin-Mediated Cell-Cell Adhesion by Rho Family GTPases;274
22;Wnt Signaling Networks and Embryonic Patterning;286
23;Cadherin-Mediated Cell-Cell Adhesion and the Microtubule Network;307
24;Matrix Metalloproteases and Epithelial-to-Mesenchymal Transition: Implications for Carcinoma Metastasis;316
25;Index;335