Schliwa Molecular Motors

1. Auflage 2006
ISBN: 978-3-527-60565-1
Verlag: Wiley-VCH
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 582 Seiten, E-Book

Jüngste Erkenntnisse über Molekulare Motoren vertiefen das Verständnis für zahlreiche biologische und medizinische Phänomene: die Mobilität von Zellen, Organell-Bewegungen, Virustransport, Asymmetrie, Myopathien und Sinnesstörungen gehen gleichermaßen auf die Funktion oder Fehlfunktion einer faszinierenden Miniatur-Mechanik zurück. Der Bedarf nach einem Handbuch über Zytoskelett-, DNA- und Rotations-Motoren, das sowohl Grundlagen als auch Anwendungen zusammenfaßt, hat sich in den letzten Jahren vervielfacht - hier ist es! Ob Funktion, Regulation oder Wechselwirkungen: der international bekannte Herausgeber sowie sein erstklassiges Autorenteam spannen den thematischen Bogen von atomaren Strukturen, Biochemie und Biophysik über Zellbiologie hin zu Entwicklungsbiologie, Pathologie und Bionanotechnologie - beste Voraussetzungen für einen echten "Klassiker"!

Autoren/Hrsg.

Schliwa, Manfred

Inhaltsverzeichnis

BASIC PRINCIPLES OF MOTOR DESIGN
Myosin Superfamily: An Overview (Kieke, Titus)
Dynein Motors: Structure, Mechanochemistry and Regulation (King)
Kinesin Superfamily Proteins (Hirokawa, Takemura)
The Bacterial Flagellar Motor (Berry)
F1-Motor of ATP Synthase (Noji)
RNA and DNA Polymerases (Korzheva, Mustaev)
Helicases as Molecular Motors (Levin, Patel)
MECHANOCHEMISTRY
How Protein Motors Convert Chemical Energy into Mechanical Work (Oster, Wang)
Example Models to Illustrate the Difference between Ratchets and Power Strokes
A Closer Look at Binding Free Energy
Molecular Motor Directionality (Endow)
Kinesins: Processivity and Chemomechanical Coupling (Hancock, Howard)
Qantitative Measurements of Myosin Movement In Vitro: The Reductionist Approach Carried to Single Molecules (Spudich)
Structure of Kinesin Motor Domains: Implications for Conformational Switching Involved in Mechanochemical Coupling (Song, Marx, Mandelkow)
Single Molecule Measurements and Molecular Motors (Ishii, Yanagida)
FUNCTIONAL IMPLICATIONS
Mitotic Spindle Motors (Scholey, Mogilner)
The Roles of Molecular Motors in Generating Developmental Asymmetry (Fischer)
Motors and Membrane Trafficking (Verhey)
Regulation of Molecular Motors (Haimo)
Molecular Motors in Plant Cells (Reddy)
MOTORS IN DISEASE
Myosin Myopathies (Konhilas, Leinwand)
The Role of Dynein in Disease (Vallee, Tai)
Molecular Motors in Sensory Defects (Avraham)
BEYOND BIOLOGICAL APPLICATIONS
Systematized Engineering of Biomotor-powered Hybrid Devices (Schmidt, Montemagno)
Synthetic Molecular Motors (Delden, Wiel, Koumura, Feringa)

BASIC PRINCIPLES OF MOTOR DESIGN
Myosin Superfamily: An Overview (Kieke, Titus)
Dynein Motors: Structure, Mechanochemistry and Regulation (King)
Kinesin Superfamily Proteins (Hirokawa, Takemura)
The Bacterial Flagellar Motor (Berry)
F1-Motor of ATP Synthase (Noji)
RNA and DNA Polymerases (Korzheva, Mustaev)
Helicases as Molecular Motors (Levin, Patel)
MECHANOCHEMISTRY
How Protein Motors Convert Chemical Energy into Mechanical Work (Oster, Wang)
Example Models to Illustrate the Difference between Ratchets and Power Strokes
A Closer Look at Binding Free Energy
Molecular Motor Directionality (Endow)
Kinesins: Processivity and Chemomechanical Coupling (Hancock, Howard)
Qantitative Measurements of Myosin Movement In Vitro: The Reductionist Approach Carried to Single Molecules (Spudich)
Structure of Kinesin Motor Domains: Implications for Conformational Switching Involved in Mechanochemical Coupling (Song, Marx, Mandelkow)
Single Molecule Measurements and Molecular Motors (Ishii, Yanagida)
FUNCTIONAL IMPLICATIONS
Mitotic Spindle Motors (Scholey, Mogilner)
The Roles of Molecular Motors in Generating Developmental Asymmetry (Fischer)
Motors and Membrane Trafficking (Verhey)
Regulation of Molecular Motors (Haimo)
Molecular Motors in Plant Cells (Reddy)
MOTORS IN DISEASE
Myosin Myopathies (Konhilas, Leinwand)
The Role of Dynein in Disease (Vallee, Tai)
Molecular Motors in Sensory Defects (Avraham)
BEYOND BIOLOGICAL APPLICATIONS
Systematized Engineering of Biomotor-powered Hybrid Devices (Schmidt, Montemagno)
Synthetic Molecular Motors (Delden, Wiel, Koumura, Feringa)