Seegers Blood Clotting Enzymology

1. Auflage 2013
ISBN: 978-1-4832-2545-6
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 640 Seiten, Web PDF

Blood Clotting Enzymology covers the mechanisms of blood clotting and their role in thrombosis, hemostasis, and many associated ramifications. This book is composed of 12 chapters that consider the integration of knowledge on blood clotting enzymology with hemostasis physiology. The opening chapter deals with the enzymology of the sol-gel transformation was studied in terms of proteins, fats, carbohydrates, surface physics, immunology, biophysical mechanisms, structural architecture, vitamin K and its antagonists, and the rheology of the blood. The subsequent chapters review the biophysical properties and composition of active substance in blood coagulation, as well as the concepts of prothrombin activation. These topics are followed by discussions on the chemical and physicochemical properties of fibrinogen and fibrin; the application of immulogical methods to delineate important properties of plasma constituents; and the mechanisms of antithrombin activity. Other chapters tackle the importance of hirudin and cobra venom for certain experimental laboratory work in the study of the physiology of blood coagulation. The final chapters survey the role of platelets in hemostasis, bleeding disorders, and the chemistry and function of vitamin K in blood coagulation. This book will prove useful to hematologists, enzyme scientist, immunologists, and research workers who are interested in blood coagulation mechanisms.

Autoren/Hrsg.

Seegers, Walter H.

Inhaltsverzeichnis

1;Front Cover;1
2;Blood Clotting Enzymology;4
3;Copyright Page;5
4;Table of Contents;10
5;List of Contributors;6
6;Preface;8
7;Chapter 1. Use and Regulation of the Blood Clotting Mechanisms;14
7.1;I. Introduction;14
7.2;II. Blood Vessel Wall Dynamics;15
7.3;III. Platelet Function;15
7.4;IV. Autoregulation in Hemostasis;17
7.5;V. Blood Coagulation;18
7.6;VI. Prothrombin Activation;20
7.7;VII. Complexity of Metabolic Integration;26
7.8;VIII. Summary;31
7.9;References;32
8;Chapter 2. Molecular Characteristics of Substances Active in Blood Coagulation;36
8.1;I. Introduction;37
8.2;II. Assay for Clotting and for Enzyme Activities;38
8.3;III. Bovine Prothrombin;39
8.4;IV. Human Prothrombin;50
8.5;V. Prothrombin of Other Species;50
8.6;VI. Bovine Thrombin;51
8.7;VII. Human Thrombin;65
8.8;VIII. Bovine Autoprothrombin C;68
8.9;IX. Bovine Prethrombin;72
8.10;X. Bovine Autoprothrombin III;74
8.11;XI. Bovine Autoprothrombins Ip and Ic;78
8.12;XII. Autoprothrombin II;79
8.13;XIII. Fibrinogen;80
8.14;XIV. Fibrin Stabilizing Factor;84
8.15;XV. Hageman Factor;85
8.16;XVI. Accelerator Globulin;88
8.17;XVII. Platelet Cofactor I (Factor VIII);90
8.18;XVIII. Plasma Thromboplastin Antecedent;92
8.19;XIX. Antithrombins;93
8.20;XX. Inhibitor Source Material;94
8.21;XXI. Substance P from Urine;95
8.22;XXII. Factor VII, Factor IX, and Factor X;95
8.23;XXIII. Platelet Factors;96
8.24;XXIV. Tissue Procoagulants;96
8.25;XXV. Lipid Procoagulants;99
8.26;XXVI. Summary;100
8.27;References;104
9;Chapter 3. Activation of Prothrombin;116
9.1;I. Introduction;117
9.2;II. Activation in Strong Salt Solutions;119
9.3;III. Activation in Strong Salt Solutions: Summary;126
9.4;IV. Activation of Prothrombin with Protamine Sulfate, and Polarized Surface Layers;127
9.5;V. Activation Characteristics of Prethrombin and Auto pro thrombin III;128
9.6;VI. Formation and Significance of Intermediate Prothrombin Activation Products;131
9.7;VII. Development of Fibrinogenolytic and Esterolytic Activities from Prothrombin;137
9.8;VIII. Dependence of Thrombin Yield on the Limited Procoagulant or Anticoagulant;138
9.9;IX. Function of Ac-Globulin and Lipids;142
9.10;X. Prothrombin in Plasma;143
9.11;XI. Two-stage Analysis Refractory State and Regeneration of Sensitivity to Two-stage Analytical Reagents;147
9.12;XII. Summary;148
9.13;ACKNOWLEDGMENT;150
9.14;References;150
10;Chapter 4. Fibrinogen to Fibrin Transformation;156
10.1;I. Early History of the Fibrinogen-Fibrin Transformation with Emphasis on Limited Proteolysis;156
10.2;II. Current Concept of the Limited Proteolysis in the Fibrinogen-Fibrin Transformation;159
10.3;III. Fibrinogen and Fibrin at the Molecular Level;199
10.4;References;221
11;Chapter 5. Immunochemistry;230
11.1;I. Introduction;231
11.2;II. Prothrombin and Its Derivatives;232
11.3;III. Accelerator Globulin (Factor V);260
11.4;IV. Platelet Cofactor I (Factor VIII);264
11.5;V. Platelet Factor 3;265
11.6;VI. Fibrinogen and Related Molecules;271
11.7;VII. Conclusion;285
11.8;ACKNOWLEDGEMENT;287
11.9;References;287
12;Chapter 6. Surface Activity in Blood Coagulation;292
12.1;I. Introduction;292
12.2;II. Contact;293
12.3;III. The Initiation of Clotting in Vivo;323
12.4;IV. The Evolution of Contact Factor;326
12.5;V. Summary and Certain Conclusions;328
12.6;References;329
13;Chapter 7. Antithrombin;336
13.1;I. Historical Background;336
13.2;II. Methods of Measurement;338
13.3;III. Preparation of Antithrombin Fractions;340
13.4;IV. Action of Antithrombin;346
13.5;V. Summary;355
13.6;ACKNOWLEDGMENTS;356
13.7;References;356
14;Chapter 8. Plasma Anticoagulants or Inhibitors;358
14.1;I. Introduction;358
14.2;II. Natural Anticoagulants;360
14.3;III. Artificial Anticoagulants;377
14.4;IV. Summary;384
14.5;References;386
15;Chapter 9. Platelets in Hemostasis;392
15.1;I. Description of Capillary Function in Thrombocytopenia;393
15.2;II. Thrombopoietic Aspects of Platelets;393
15.3;III. Platelet Functions;399
15.4;IV. Metabolism of Platelets;421
15.5;V. Platelet Preservation;426
15.6;VI. Immunological Aspects of Platelets;426
15.7;VII. Platelet Transfusion;427
15.8;VIII. Summary;428
15.9;References;429
16;Chapter 10. Irregular Blood Coagulation;434
16.1;I. Introduction;434
16.2;II. Inherited Bleeding Disorders;436
16.3;III. Acquired Bleeding Disorders;466
16.4;IV. Summary;484
16.5;References;488
17;Chapter 11. Ultras tructure of the Fibrin Clot;500
17.1;I. Introduction;501
17.2;II. Specific Aims;502
17.3;III. Normal Fibrin Formation;502
17.4;IV. Abnormal Fibrin Formation;525
17.5;V. Conclusions;558
17.6;References;558
18;Chapter 12. Chemistry and Function of Vitamin K;564
18.1;I. Introduction;564
18.2;II. Chemistry of the K Vitamins;565
18.3;III. Detection and Determination;567
18.4;IV. Occurrence;570
18.5;V. Structural Specificity of Vitamin K Action;572
18.6;VI. Metabolism;574
18.7;VII. Vitamin K-II (S);585
18.8;References;586
19;AUTHOR INDEX;590
20;SUBJECT INDEX;617