Shah Stem Cell Therapeutics for Cancer

1. Auflage 2013
ISBN: 978-1-118-66062-1
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: 0 - No protection

E-Book, Englisch, 304 Seiten, E-Book

Stem Cell Therapeutics for Cancer covers theapplication of stem cells in various cancers, with an emphasis onthe aspects of these strategies that are critical to the success offuture stem cell-based therapies for cancer. Topics covered in thebook include stem cell sources, tumor specificity, targetedtherapeutics, visualizing the stem cell, and therapeutic agentpharmacokinetics. Each chapter contains a brief introduction to thecancer, followed by an exploration of how engineered stem cellshave been utilized to cure the disease in mouse models and in earlyphase clinical trials.
* Comprises of sections on stem cell therapy in brain cancers,lung cancers, breast cancers, as well as stem cells incombination with other therapies
* Focuses on the practical applications of using stem cells asgene delivery agents to treat cancer
* Includes coverage of cutting-edge molecular imaging techniquesin stem cell therapeutics for a variety of tumour types

Autoren/Hrsg.

Shah, Khalid

Inhaltsverzeichnis

Contributors vii
Preface xi
Section 1 Introduction 1
1 Stem Cell Sources and Their Potential for Cancer Therapeutics3
Khalid Shah
Section 2 Migration and Fate of Stem Cells 11
2 The Role of CXCR4 as a Mediator of Glioma-Tropic NeuralPrecursor Cell Migration 13
Moneeb Ehtesham, Elliot Min, and Rebecca Kasl
3 Tumor Tropism of Mesenchymal Stem Cells 21
Paula Y. P. Lam and Ivy A.W. Ho
Section 3 Stem Cell Therapy in Brain Cancer 39
4 Stem Cell-Mediated Trail Therapy for Highly Aggressive BrainTumors 41
Khalid Shah
5 Stem Cell-Mediated Prodrug Gene Therapy of High-Grade BrainTumors 57
Cestmir Altaner
6 Role of Naïve Cord Blood Stem Cells in Glioma Therapy73
Venkata Ramesh Dasari, Kiran Kumar Velpula, and Jasti S.Rao
7 Stem Cell-Based Antiangiogenic Therapies for Brain Tumors87
Navid Redjal and Khalid Shah
8 Treatment of Metastatic Neuroblastoma with Mesenchymal StemCell-Based Oncolytic Virotherapy 103
Manuel Ramírez and Javier García-Castro
Section 4 Stem Cell Therapy in Other Cancer Types 111
9 Umbilical Cord Matrix Stem Cells for Cytotherapy of BreastCancer 113
Naomi Ohta, Atsushi Kawabata, Deepthi Uppalapati, SusumuIshiguro, Deryl Troyer, and Masaaki Tamura
10 Mesenchymal Stromal Cells as Effective TumorAntigen-Presenting Cells in Cancer Therapeutics 127
Raphaëlle Romieu-Mourez and Jacques Galipeau
11 Diagnostic and Therapeutic Mesenchymal Stem Cells for BreastCancer Treatment 145
Róisín Dwyer
12 Genetically Engineered Stem Cell Therapies TargetingGastrointestinal Malignancy 159
Emily Keung, Peter J. Nelson, and Claudius Conrad
13 Mesenchymal Stem Cells in Prostate Cancer: ClinicalOpportunities 171
Diptiman Chanda and Selvarangan Ponnazhagan
14 Primed Mesenchymal Stromal Cells for Cancer Therapy 187
Augusto Pessina, Arianna Bonomi, Eugenio Parati, RobertoPallini, and Giulio Alessandri
Section 5 Combinatorial Stem Cell Therapies 203
15 MicroRNA Adjuvants in Stem Cell-Based Cancer Therapy205
Maarten C. J. Anderegg and Maarten F. Corsten
16 Stem Cell-Based Combination Therapies for Cancer: SystemicDelivery of a PI3K/mTOR Inhibitor (PI-103) and Stem Cell-MediatedDelivery of TRAIL in Brain Tumors 219
Tugba Bagci-Onder
17 The Efficacy of Clinically Approved Agents with StemCell-Delivered Therapeutics for Cancer Therapy 235
Hiroaki Wakimoto and Khalid Shah
Section 6 Tracking Stem Cells and Stem Cell-BasedTherapeutics 245
18 Imaging Migration and Fate of Stem Cells in ExperimentalModels of Cancer 247
Deepak Bhere and Khalid Shah
19 Multifunctional Molecules for Interrogating Stem Cell-BasedTherapeutics 257
Shawn Hingtgen
20 Tracking Cancer-Targeted MSC with PET Imaging 273
Véronique Roelants and Jean-Louis Vanoverschelde
Index 289
Color plate is located between pages 244 and 245.