Sigel Interplay between Metal Ions and Nucleic Acids

1. Auflage 2012
ISBN: 978-94-007-2172-2
Verlag: Springer Netherland
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 354 Seiten

Reihe: Chemistry and Materials Science

Interplay between Metal Ions and Nucleic Acids provides in an authoritative and timely manner in 12 stimulating chapters, written by 24 internationally recognized experts from 8 nations, and supported by nearly 1500 references, about 20 tables, and 125 illustrations, many in color, a most up-to-date view on metal ion-nucleic acid interactions; the characterization of which is covered in solution and in the solid state. The volume concentrates on modern developments encompassing topics in the wide range from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs) being thus of relevance, e.g., for chemistry and nanotechnology but also for molecular biology and (genetic) diagnostics.

Zielgruppe

Research

Autoren/Hrsg.

Sigel, Astrid

Sigel, Helmut

Sigel, Roland KO

Inhaltsverzeichnis

1. Characterization of Metal Ion-Nucleic Acid Interactions in Solution. - 2. Nucleic Acid-Metal Ion Interactions in the Solid State. - 3. Metal Ion-Promoted Conformational Changes of Oligonucleotides. - 4. G-Quadruplexes and Metal Ions. - 5. Metal Ion-Mediated DNA-Protein Interactions. - 6. Spectroscopic Investigations of Lanthanide Ion Binding to Nucleic Acids. - 7. Oxidative DNA Damage Mediated by Transition Metal Ions and Their Complexes. - 8. Metal Ion-Dependent DNAzymes and Their Applications as Biosensors. - 9. Enantioselective Catalysis at the DNA Scaffold. - 10. Alternative DNA Base Pairing through Metal Coordination. - 11. Metal-Mediated Base Pairs in Nucleic Acids with Purine- and Pyrimidine-Derived Nucleosides. - 12. Metal Complex Derivatives of Peptide Nucleic Acids.