Buch, Englisch, 464 Seiten, Paperback (Thread Stitching), Format (B × H): 195 mm x 270 mm, Gewicht: 1179 g
Buch, Englisch, 464 Seiten, Paperback (Thread Stitching), Format (B × H): 195 mm x 270 mm, Gewicht: 1179 g
ISBN: 978-3-13-173111-1
Verlag: Thieme
Covering all state-of-the-art experimental research methods in orthopedic surgery and trauma
From bioinformatics to nanotechnology, advances in basic research ultimately drive advances in clinical care. This book provides a comprehensive summary of all current research methodologies for translational and pre-clinical studies in biomechanics and orthopedic trauma surgery. With this "roadmap" at hand, specialists and trainees will have the tools to conduct high-quality experimental research in any area of musculoskeletal science, with a solid understanding of how the findings can be applied in patient care.
Special Features:
- Utilizes the principles and methodology of modern, evidence-based medicine in pre-clinical musculoskeletal research - Offers a comprehensive analysis of in vivo models for studying different components of the musculoskeletal system - Demonstrates how principles of structural, functional, and numerical biomechanics can be utilized in well-defined experimental research studies – spanning topics from fracture fixation to gait analysis to bone remodeling - Covers the role of new macroscopic CT and ultrasound imaging techniques for assessing bone and cartilage function - Explores cutting-edge developments in cell culture research, molecular testing, and tissue engineering - Provides practical advice, a glossary of key terminology, and hundreds of illustrations to familiarize clinicians with every aspect of designing and interpreting an effective research study
With 54 state-of-the-art chapters by orthopedic surgeons, musculoskeletal physicians, biologists, engineers, physicists, and mathematicians, Experimental Research Methods in Orthopedics and Trauma is the authoritative reference on the topic. It is essential for clinicians, basic researchers, and orthopedic surgical trainees who need to understand experimental research methodology
Zielgruppe
Ärzte
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Part 1 Why Do We Need Experimental Research?1 Evidence-Based Research2 Establishing a Basic Research Facility in Orthopedic Surgery3 Good Laboratory Practice and Quality Control4 How to Prepare for a Period in ResearchPart 2 Structural Biomechanics5 Physiological Boundary Conditions for Mechanical Testing6 Static, Dynamic, and Fatigue Mechanical Testing7 Use of Human and Animal Specimens in Biomechanical Testing8 Whole Bone Biomechanics9 Biomechanics of Trabecular and Cortical Bone10 Biomechanics of Fracture Fixation11 Biomechanical Assessment of Fracture Repair12 Biomechanics of Cartilage13 Biomechanics of Joints14 Spine BiomechanicsPart 3 Functional Biomechanics15 Musculokeletal Dynamics16 Measurement Techniques17 Clinical Assessment of Function18 Functional Biomechanics with Cadaver SpecimensPart 4 Numerical Biomechanics19 Inverse Dynamics20 Principles of Finite Elements Analysis21 Validation of Finite Element Models22 Computational Biomechanics of Bone23 Numerical Simulation of Implants and Prosthetic Devices24 Numerical Simulation of Fracture Healing and Bone RemodellingPart 5 Imaging25 Micro-Computed Tomography Imaging of Bone Tissue26 Imaging Bone27 Ultrasound Techniques for Imaging Bone28 In Vivo Scanning29 Imaging of Cartilage Function30 Histochemistry Bone and Cartilage31 Immunohistochemistry32 Molecular Imaging In Situ Hybridization33 Laser Scanning Confocal Microscopy and Laser Microdissection34 Image Analysis Histomorphometry StereologyPart 6 Cellular Studies35 Cell Culture Research36 Cartilage Explants and Organ Culture Models37 Fluid Flow and Strain in Bone38 Biomechanics of Bone CellsPart 7 Molecular Techniques in Bone Repair39 Molecular Testing40 Genetically Modified Models for Bone RepairPart 8 In Vivo Models41 General Considerations for an In Vivo Model42 Animal Models for Bone Healing43 Models for Impaired Healing44 In Vivo Models for Bone and Joint Infections45 In Vivo Models for Articular Cartilage Repair46 In Vivo Soft Tissue ModelsPart 9 Tissue Engineering47 Scaffolds for Tissue Engineering and Materials for Repair48 Use of Growth Factors in Musculoskeletal Research49 Stem Cells for Musculoskeletal Repair50 Biological Evaluation and Testing of Medical DevicesPart 10 Statistics for Experimental Research51 Study Design52 Power and Sample Size Calculation53 Nonparametric versus Parametric Tests54 How to Limit Bias in Experimental Research
