E-Book, Englisch, 464 Seiten, ePub
Simpson / Augat Experimental Research Methods in Orthopedics and Trauma
1. Auflage 2015
ISBN: 978-3-13-258147-0
Verlag: Thieme
Format: EPUB
Kopierschutz: 6 - ePub Watermark
E-Book, Englisch, 464 Seiten, ePub
ISBN: 978-3-13-258147-0
Verlag: Thieme
Format: EPUB
Kopierschutz: 6 - ePub Watermark
From bioinformatics to nanotechnology, advances in basic research ultimately drive advances in clinical care. This book provides a comprehensive summary of all current research methodologies for translational and pre-clinical studies in biomechanics and orthopedic trauma surgery. With this 'roadmap' at hand, specialists and trainees will have the tools to conduct high-quality experimental research in any area of musculoskeletal science, with a solid understanding of how the findings can be applied in patient care.
Special Features:
- Utilizes the principles and methodology of modern, evidence-based medicine in pre-clinical musculoskeletal research
- Offers a comprehensive analysis of in vivo models for studying different components of the musculoskeletal system
- Demonstrates how principles of structural, functional, and numerical biomechanics can be utilized in well-defined experimental research studies – spanning topics from fracture fixation to gait analysis to bone remodeling
- Covers the role of new macroscopic CT and ultrasound imaging techniques for assessing bone and cartilage function
- Explores cutting-edge developments in cell culture research, molecular testing, and tissue engineering
- Provides practical advice, a glossary of key terminology, and hundreds of illustrations to familiarize clinicians with every aspect of designing and interpreting an effective research study
With 54 state-of-the-art chapters by orthopedic surgeons, musculoskeletal physicians, biologists, engineers, physicists, and mathematicians, is the authoritative reference on the topic. It is essential for clinicians, basic researchers, and orthopedic surgical trainees who need to understand experimental research methodology
Zielgruppe
Ärzte
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
Part 1 Why Do We Need Experimental Research? 1 Evidence-Based Research 2 Establishing a Basic Research Facility in Orthopedic Surgery 3 Good Laboratory Practice and Quality Control 4 How to Prepare for a Period in Research Part 2 Structural Biomechanics 5 Physiological Boundary Conditions for Mechanical Testing 6 Static, Dynamic, and Fatigue Mechanical Testing 7 Use of Human and Animal Specimens in Biomechanical Testing 8 Whole Bone Biomechanics 9 Biomechanics of Trabecular and Cortical Bone 10 Biomechanics of Fracture Fixation 11 Biomechanical Assessment of Fracture Repair 12 Biomechanics of Cartilage 13 Biomechanics of Joints 14 Spine Biomechanics Part 3 Functional Biomechanics 15 Musculokeletal Dynamics 16 Measurement Techniques 17 Clinical Assessment of Function 18 Functional Biomechanics with Cadaver Specimens Part 4 Numerical Biomechanics 19 Inverse Dynamics 20 Principles of Finite Elements Analysis 21 Validation of Finite Element Models 22 Computational Biomechanics of Bone 23 Numerical Simulation of Implants and Prosthetic Devices 24 Numerical Simulation of Fracture Healing and Bone Remodelling Part 5 Imaging 25 Micro-Computed Tomography Imaging of Bone Tissue 26 Imaging Bone 27 Ultrasound Techniques for Imaging Bone 28 In Vivo Scanning 29 Imaging of Cartilage Function 30 Histochemistry Bone and Cartilage 31 Immunohistochemistry 32 Molecular Imaging In Situ Hybridization 33 Laser Scanning Confocal Microscopy and Laser Microdissection 34 Image Analysis Histomorphometry Stereology Part 6 Cellular Studies 35 Cell Culture Research 36 Cartilage Explants and Organ Culture Models 37 Fluid Flow and Strain in Bone 38 Biomechanics of Bone Cells Part 7 Molecular Techniques in Bone Repair 39 Molecular Testing 40 Genetically Modified Models for Bone Repair Part 8 In Vivo Models 41 General Considerations for an In Vivo Model 42 Animal Models for Bone Healing 43 Models for Impaired Healing 44 In Vivo Models for Bone and Joint Infections 45 In Vivo Models for Articular Cartilage Repair 46 In Vivo Soft Tissue Models Part 9 Tissue Engineering 47 Scaffolds for Tissue Engineering and Materials for Repair 48 Use of Growth Factors in Musculoskeletal Research 49 Stem Cells for Musculoskeletal Repair 50 Biological Evaluation and Testing of Medical Devices Part 10 Statistics for Experimental Research 51 Study Design 52 Power and Sample Size Calculation 53 Nonparametric versus Parametric Tests 54 How to Limit Bias in Experimental Research
Contributors
Rana Abou-Khalil
Senior Research Fellow
INSERM UMR1163
Université Paris Descartes-Sorbonne Paris Cité
Institut Imagine
Hôpital Necker-Enfants Malades
Paris, France
Kishan Victoria Aldridge, BSc(Hons), MBChB(Hons), MRCS(Ed), MSc
ECAT Clinical Lecturer University of Edinburgh
MRC Human Genetics Unit
The MRC Institute of Genetics and Molecular Medicine
The University of Edinburgh
Western General Hospital
Edinburgh, Scotland, United Kingdom
Roland Aldridge, PhD
Clinical Lecturer and Honorary Special Registrar in General Surgery
Department of Clinical Surgery
The University of Edinburgh
Edinburgh, Scotland, United Kingdom
Volker Alt, MD, PhD
Deputy Clinic Director
Department of Orthopaedic Trauma Surgery University
Hospital Giessen-Marburg GmbH, Campus Giessen
Justus-Liebig-University Giessen
Giessen, Germany
Andrew A. Amis, Prof. FREng, DSc(Eng)
Professor of Orthopaedic Biomechanics
Department of Mechanical Engineering
Imperial College London
London, United Kingdom
Richard van Arkel, MEng
Imperial College London
Department of Mechanical Engineering
London, United Kingdom
Peter Augat, PhD
Professor of Biomechanics
Paracelsus Medical University
Salzburg, Austria
Director
Institute of Biomechanics
Trauma Center Murnau
Murnau am Staffelsee, Germany
Astrid D. Bakker, PhD
Associate Professor
Department of Oral Cell Biology
Academic Centre for Dentistry Amsterdam (ACTA)
University of Amsterdam and VU University Amsterdam
MOVE Research Institute Amsterdam
Amsterdam, The Netherlands
Spencer Behr, MD, PhD
Assistant Professor
Department of Radiology and Biomedical Imaging
University of California San Francisco (UCSF)
San Francisco, California, United States
Pinaki Bhattacharya, PhD
KU Leuven - University of Leuven
Department of Mechanical Engineering
Leuven, Belgium
Taco Johan Blokhuis, PhD
Department of Surgery/Traumatology
Utrecht University Medical Center
Utrecht, The Netherlands
Torsten Blunk, PhD
Department of Trauma, Hand, Plastic and Reconstructive Surgery
University of Würzburg
Würzburg, Germany
Gordon William Blunn, PhD
John Scales Centre for Biomedical Engineering
Institute of Orthopaedics and Musculoskeletal Science
Division of Surgery and Interventional Science
University College London
Royal National Orthopaedic Hospital
Middlesex, United Kingdom
Joseph Borrelli, Jr, MD
Orthopedic Surgeon
Texas Health Physicians Group
Texas Health Arlington Memorial Hospital
Arlington, Texas, United States
Nathalie Bravenboer
Senior Researcher
Department of Clinical Chemistry
MOVE Research Institute Amsterdam
VU University Medical Center
Amsterdam, The Netherlands
Wing-Hoi Cheung, PhD
Associate Professor
Department of Orthopaedics and Traumatology
The Chinese University of Hong Kong
Shatin, Hong Kong, China
Simon Kwoon Ho Chow, BSc, MSc, PhD
Department of Orthopaedics and Traumatology
The Chinese University of Hong Kong
Shaitin, Hong Kong, China
Nicholas Clement
Department of Orthopaedics and Trauma
Edinburgh University
Edinburgh, Scotland, United Kingdom
Melanie Jean Coathup
Senior Lecturer in Orthopaedics
John Scales Centre for Biomedical Engineering
Institute of Orthopaedics and Musculoskeletal Science
Division of Surgery and Interventional Science
University College London
Royal National Orthopaedic Hospital
Middlesex, United Kingdom
Céline Colnot, PhD
INSERM UMR1163
Université Paris Descartes-Sorbonne Paris Cité
Institut Imagine
Hôpital Necker-Enfants Malades
Paris, France
Luca Cristofolini, PhD
Professor of Biomechanics
Department of Industrial Engineering
School of Engineering and Architecture
University of Bologna
Bologna, Italy
Dieter R. Dannhorn, PhD
Owner and General Manager
Dr Dannhorn Consulting and More
Erolzheim, Germany
Hannah Darton
PhD Student
Imperial College London
Department of Mechanical Engineering
South Kensington Campus
London, United Kingdom
Marcel Dijkgraaf, PhD
Consultant in Clinical Research Methodology and Statistics
Clinical Research Unit
Academic Medical Center Amsterdam
Amsterdam, The Netherlands
Lutz Dürselen, PhD
Professor of Biomechanics
Head of Joint Biomechanics Research Group
Institute of Orthopaedic Research and Biomechanics
Centre of Musculoskeletal Research Ulm
Ulm University
Ulm, Germany
Sebastian Eberle, PhD
Computational Engineer
KRP-Mechatec Engineering GbR
Munich, Germany
Regina Ebert, PD PhD
Orthopedic Center for Musculoskeletal Research
University of Würzburg
Würzburg, Germany
Nan van Geloven, PhD
Biostatistician
Clinical Research Unit
Academic Medical Center Amsterdam
Amsterdam, The Netherlands
Allen Edward Goodship, BVSc, PhD, MRCVS
Emeritus Professor of Orthopaedics
John Scales Centre for Biomedical Engineering
Institute of Orthopaedics and Musculoskeletal Science
Division of Surgery and Interventional Science
University College London
Royal National Orthopaedic Hospital
Middlesex, United Kingdom
Rob de Haan, PhD
Professor of Clinical Epidemiology
Clinical Research Unit
Academic Medical Center Amsterdam
Amsterdam, The Netherlands
Camilla Halewood, MEng, MBiomedE
Biomechanical Engineer
Department of Mechanical Engineering
Imperial College London
London, United Kingdom
David Hamilton, PhD
Department of Orthopaedics
University of Edinburgh
Edinburgh, Scotland, United Kingdom
Kurt D. Hankenson, DVM, PhD
Associate Professor
Department of Physiology
Associate Director
Laboratory for Comparative Orthopedic Research
Michigan State University
East Lansing, Michigan, United States
Markus O. Heller, PhD
Professor of Biomechanics
University of Southampton
Bioengineering Science Research Group
Faculty of Engineering and the Environment
Southampton, United Kingdom
Christoph Henkenberens
Department of Trauma Surgery
University Hospital Giessen-Marburg GmbH,
Campus Giessen, Germany
Laboratory of Experimental Trauma Surgery,
Justus-Liebig-University
Giessen, Germany
Safa Herfat, PhD
Orthopaedic Trauma Institute
Department of Orthopaedic Surgery
University of California at San Francisco
San Francisco General Hospital
San Francisco, California, United States
Paul Hindle, MBChB, MRCS (Eng), RAF
Trauma and Orthopaedic Registrar
The Royal Infirmary of Edinburgh
Edinburgh, Scotland, United Kingdom
Timothy M. Jackman
Department of Biomedical Engineering
Boston University
Boson, Massachusetts, United States
Franz Jakob, Prof. Dr.
Orthopedic Center for Musculoskeletal Research
Orthopedic Department
University of Würzburg
Würzburg, Germany
Ineke D.C. Jansen, PhD
Department of Periodontology
Academic Centre for Dentistry Amsterdam (ACTA)
University of Amsterdam and VU University Amsterdam
MOVE Research Institute Amsterdam
Amsterdam, The Netherlands
Richard T. Jaspers, PhD
Assistant Professor
Laboratory for Myology
MOVE Research Institute Amsterdam
Faculty of Human Movement Sciences
VU University Amsterdam
Amsterdam, The Netherlands
Paul J. Jenkins, MBChB, MRCS(Ed)
Consultant Orthopaedic Surgeon
Glasgow Royal Infirmary
Glasgow, Scotland, United Kingdom
Gabby B. Joseph, PhD
Musculoskeletal and Quantitative Imaging Research Group
Department of Radiology and Biomedical Imaging
University of California San Francisco
San Francisco, California, United States
Petra Juffer, PhD
Department of Oral Cell Biology
Academic Centre for Dentistry Amsterdam (ACTA)
University of Amsterdam and VU University Amsterdam
MOVE Research Institute Amsterdam
Amsterdam, The Netherlands
Christian Kaddick, PhD
EndoLab
Mechanical Engineering GmbH
Rosenheim, Germany
Grace Kim, PhD
Sibley School of Mechanical & Aerospace Engineering
Cornell University
Ithaca, New York, United States
Jenneke Klein-Nulend, PhD
Professor
Department of Oral Cell Biology
Academic Centre for Dentistry Amsterdam (ACTA)
University of Amsterdam and VU University Amsterdam
MOVE Research Institute Amsterdam
Amsterdam, The...
