Singh / Grosschedl Molecular Analysis of B Lymphocyte Development and Activation

1. Auflage 2006
ISBN: 978-3-540-26363-0
Verlag: Springer Berlin Heidelberg
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band 290, 260 Seiten

Reihe: Current Topics in Microbiology and Immunology

The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation.

Autoren/Hrsg.

Singh, Harinder

Grosschedl, Rudolf

Inhaltsverzeichnis

1;Preface;5
2;Obituary;6
3;List of Contents;8
4;List of Contributors;9
5;Gene Regulatory Networks Orchestrating B Cell Fate Specification, Commitment, and Differentiation;10
5.1;1 Introduction;10
5.2;2 Specification and Commitment to the B Cell Fate;11
5.3;3 Regulation of Ig Gene Rearrangement and Pre-B Cell Differentiation;17
5.4;4 Conclusions and Perspectives;19
5.5;References;19
6;Helix-Loop-Helix Proteins in Lymphocyte Lineage Determination;23
6.1;1 Introduction;23
6.2;2 E2A Proteins;25
6.3;3 Class VI HLH Proteins: Hes-1/5;28
6.4;4 Id Proteins;28
6.5;5 Conclusions and Future Directions;29
6.6;References;32
7;Ikaros-Family Proteins: In Search of Molecular Functions During Lymphocyte Development;36
7.1;1 Introduction;37
7.2;2 Discovery;37
7.3;3 Structure and Family Members;38
7.4;4 Genetics;40
7.5;5 Localization to Centromeric Heterochromatin;42
7.6;6 Centromere Structure and Function;44
7.7;7 Centromere Role During Interphase;46
7.8;8 Potential Ikaros Functions at Pericentromeric Heterochromatin;47
7.9;9 Future Directions;49
7.10;References;50
8;Biochemistry of V(D)J Recombination;55
8.1;1 Introduction;56
8.2;2 DNA Transactions in V(D)J Recombination;59
8.3;3 Proteins That Mediate V(D)J Recombination;60
8.4;4 Recent Insights from In Vitro Cleavage Studies;68
8.5;5 Sequence-Specific Binding of the Recombination Signal by RAG1 and RAG2;73
8.6;6 Future Prospects;81
8.7;7 Epilogue;82
8.8;References;84
9;The pre-B cell Receptor in B Cell Development: Recent Advances, Persistent Questions and Conserved Mechanisms;92
9.1;1 Introduction;93
9.2;2 Commitment to the B Cell Lineage;94
9.3;3 The Development of Pre-B Cells;95
9.4;4 Initiating Signals Through the Pre-BCR;96
9.5;5 Different Signals for Different Functions;99
9.6;6 The Pre-TCR and Pre-BCR: Conservation of Signaling Properties and Functions?;101
9.7;7 Final Comments;102
9.8;References;103
10;Transcriptional Control of B Cell Activation;109
10.1;1 Introduction;110
10.2;2 Octamer-Binding Proteins and Cofactors;113
10.3;3 Rel-NF- kB Family Proteins;118
10.4;4 Pax-5/BSAP;123
10.5;5 Ets-1 Family Proteins;125
10.6;6 Ikaros Family Proteins;128
10.7;7 NF-AT Family Proteins;129
10.8;8 Other Transactivators Implicated in B Cell Activation;130
10.9;9 Concluding Remarks;134
10.10;References;136
11;Expression of MHC II Genes;151
11.1;1 Innate and Adaptive Immunity;152
11.2;2 Class II Transactivator;161
11.3;3 Conclusions and Future Directions;169
11.4;References;170
12;Class Switch Recombination: An Emerging Mechanism;175
12.1;1 Introduction;176
12.2;2 Overview of CSR;177
12.3;3 A Model for the Initiation and Resolution Steps in CSR;179
12.4;4 CSR and SHM Uncoupled;188
12.5;5 Genome Instability Syndromes and CSR;189
12.6;6 Targeting Mechanisms in CSR;191
12.7;7 Concluding Remarks;197
12.8;References;198
13;Blimp-1; Immunoglobulin Secretion and the Switch to Plasma Cells;204
13.1;1 Plasma Cell Biology;205
13.2;2 Transcriptional Regulation of Ig Secretion;208
13.3;3 Blimp-1-Regulated Maturation Program;212
13.4;4 Post-translational Regulation of Ig Secretion;220
13.5;5 Remarks and Future Directions;222
13.6;References;224
14;Wnt Signaling in Lymphopoiesis;228
14.1;1 Overview of the Different Wnt Signaling Pathways;229
14.2;2 The Canonical Wnt Signaling Pathway;230
14.3;3 Biochemical and Biological Properties of LEF/TCF Proteins;232
14.4;4 Activation of LEF1/TCF Function by b- Catenin and Other Cofactors;235
14.5;5 Transcriptional Repression and Inhibition of LEF1/TCF Function;237
14.6;6 Hematopoiesis;238
14.7;7 Role of the Wnt Pathway in Hematopoietic Stem Cells;240
14.8;8 Role of Wnt Signaling in Pro-B cell Proliferation and Survival;241
14.9;9 Role of Wnt Signaling in T Cell Development;243
14.10;10 Role of LEF/TCF in NK Cell Development;246
14.11;11 Concluding Remarks;247
14.12;References;247
15;Subject Index;256