Sourcebook of Models for Biomedical Research

1. Auflage 2008
ISBN: 978-1-59745-285-4
Verlag: Humana Press
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 778 Seiten

The collection of systems represented in Sourcebook of genomic programs, although this work is certainly well Models for Biomedical Research is an effort to re?ect the represented and indexed. diversity and utility of models that are used in biomedicine. Some models have been omitted due to page limitations That utility is based on the consideration that observations and we have encouraged the authors to use tables and made in particular organisms will provide insight into the ? gures to make comparisons of models so that observations workings of other, more complex, systems. Even the cell not available in primary publications can become useful to cycle in the simple yeast cell has similarities to that in the reader. humans and regulation with similar proteins occurs. We thank Richard Lansing and the staff at Humana for Some models have the advantage that the reproductive, guidance through the publication process. mitotic, development or aging cycles are rapid compared As this book was entering production, we learned of the with those in humans; others are utilized because individual loss of Tom Lanigan, Sr. Tom was a leader and innovator proteins may be studied in an advantageous way and that in scienti?c publishing and a good friend and colleague to have human homologs. Other organisms are facile to grow all in the exploratory enterprise. We dedicate this book to in laboratory settings or lend themselves to convenient analy- his memory. We will miss him greatly.

Autoren/Hrsg.

Inhaltsverzeichnis

1;Preface;5
2;Contents;6
3;Contributors;10
4;List of Color Plates;14
5;I INTRODUCTION;16
5.1;Animal Models for Human Diseases;17
5.2;Selection of Biomedical Animal Models;23
5.3;Improved Models for Animal Research;30
6;II GENERAL CONSIDERATIONS;38
6.1;The Ethical Basis for Animal Use in Research;39
6.2;Bibliographic Searching Tools on Disease Models to Locate Alternatives for Animals in Research;46
6.3;NIH Policies on Sharing of Model Organisms and Related Research Resources;53
6.4;Databases for Biomedical Animal Resources;59
6.5;Psychological Enrichment for Animals in Captivity;65
7;III WELL-ESTABLISHED MODELS: A Yeast, Worms, Flies, Sea Animals, and Birds;74
7.1;Integrated Network Modeling of Molecular and Genetic Interactions;75
7.2;The Sponge as a Model of Cellular Recognition;83
7.3;Sea Urchin Embryo;92
7.4;Models of Human;98
7.5;Neurodegenerative Diseases;98
7.6;Zebrafish as a Model for Development;109
7.7;Zebrafish as a Model for Studying Adult Effects of Challenges to the Embryonic Nervous System;119
7.8;Modeling Cognitive and Neurodegenerative Disorders in;127
7.9;Biomedical Research with Honey Bees;135
7.10;Establishing and Maintaining a;145
7.11;Colony for Research Laboratories;145
7.12;The Chicken as a Model Organism;167
8;III WELL-ESTABLISHED MODELS: B Rodents;174
8.1;Rat Knockout and Mutant Models;175
8.2;Rodent Genetics, Models, and Genotyping Methods;183
8.3;The House Mouse in Biomedical Research;191
8.4;Mouse Model for Alzheimer’s Disease;195
8.5;Guinea Pigs as Models for Human Cholesterol and Lipoprotein Metabolism;204
8.6;Reliability of Rodent Models;216
8.7;The Domestic Cat, Felis catus, as a Model of Hereditary and Infectious Disease;222
8.8;Swine in Biomedical Research;234
8.9;The Minipig as an Animal Model in Biomedical Stem Cell Research;241
8.10;The Nonhuman Primate as a Model for Biomedical Research;250
8.11;Primates as Models of Behavior in Biomedical Research;258
8.12;Primate Models for Understanding Brain Mechanisms of Cognitive Behavior;266
8.13;Animal Models for Eye Diseases and Therapeutics;277
8.14;Animal Models of Noise-Induced Hearing Loss;286
9;IV MODELS FOR SPECIFIC PURPOSES;299
9.1;Human and Animal Models for the Study of Muscle Pain;300
9.2;Animal Models of Parkinson’s Disease;308
9.3;Transgenic Animal Models of Neurodegenerative Diseases;318
9.4;Animal Models of Nociception and Pain;327
9.5;Nonmammalian Models for the Study of Pain;334
10;V MODELS OF BEHAVIOR: A Cardiovascular;346
10.1;Animal Models of Vascular Development and Endothelial Cell Biology;347
10.2;Models of Behavior;353
10.3;Animal Models for Atherosclerosis, Restenosis, and Endovascular Aneurysm Repair;361
10.4;Transgenic Mouse Models of HIV-1/AIDS and Cardiac Performance;377
11;V MODELS OF BEHAVIOR: B Reproduction;386
11.1;Primate Models for the Assisted Reproductive Technologies and Embryonic Stem Cell Biology;387
11.2;Rat Models of Polycystic Ovary Syndrome;395
11.3;Murine Models for Reproduction;401
11.4;Pig Model to Study Dynamics of Steroids During Ovarian Follicular Growth and Maturation;414
12;V MODELS OF BEHAVIOR: Drug Development and Research Models;426
12.1;Molecular Genetic Approach to Identify Inhibitors of Signal Transduction Pathways;427
12.2;Yeast as a Model System to Study DNA Damage and DNA Repair;432
13;V MODELS OF BEHAVIOR: D Physiology;441
13.1;Human Models of Space Physiology;442
13.2;Developmental Space Biology of Mammals;450
13.3;A Practical Approach to Animal Models of Sepsis;458
13.4;Animal Models in Functional Magnetic Resonance Imaging;468
13.5;Animal Models in Aging Research;484
14;V MODELS OF BEHAVIOR: E Genetics;492
14.1;Gene Targeting in Human Somatic Cells;493
14.2;Animal Models for Investigating the Causes and Mechanisms of Mammalian Germ Cell Aneuploidy;510
14.3;Genetic Models of Alzheimer’s Disease;521
15;V MODELS OF BEHAVIOR: F Immunology and Virology;527
15.1;Rat Models of Experimental Autoimmune Encephalomyelitis;528
15.2;Animal Models in Virology;538
15.3;Nonhuman Primate Models for AIDS;545
16;VI Models of other Human Diseases;553
16.1;Use of Congenic Mouse Strains for Candidate Disease Gene Identi . cation in Complex Traits;554
16.2;Animal Models of Sudden Infant Death Syndrome;561
16.3;Animal Models of Posttraumatic Stress Disorder;569
16.4;Animal Models for Studying Fetal Alcohol Syndrome, Alcohol- Related Birth Defects, and Alcohol- Related Neurodevelopmental Disorder;580
16.5;Modeling Drug and Alcohol Abuse;592
16.6;Mouse Models for Experimental Cancer Therapy;600
16.7;Rat Models of Skin Wound Healing;607
16.8;Animal Models of Prostate Cancer;615
16.9;Animal Models of Diabetes;626
16.10;Animal Models of Kidney Diseases;632
16.11;Animal Models of Multiple Sclerosis;640
16.12;Canine and Feline Models for Cancer;652
16.13;Obese Mouse Models;658
16.14;Study of Polycystic Kidney Disease in the;678
16.15;Nematode;678
16.16;Animal Models of Myelo.brosis;687
16.17;Animal Models for Bone Tissue Engineering Purposes;698
16.18;Markov Processes for Biomedical Data Analysis;711
16.19;Software Tools for Modeling Biomedical Systems;718
16.20;Developing Websites for Biomedical Research and Training;724
16.21;Building Virtual Research Communities Using Web Technology;729
17;Index;733