Stephanos / Addison Chemistry of Metalloproteins

Problems and Solutions in Bioinorganic Chemistry
1. Auflage 2014
ISBN: 978-1-118-80152-9
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 448 Seiten, E-Book

Reihe: Wiley Series in Protein and Peptide Science

Addresses the full gamut of questions in metalloproteinscience
Formatted as a question-and-answer guide, this book examines allmajor families of metal binding proteins, presenting our mostcurrent understanding of their structural, physicochemical, andfunctional properties. Moreover, it introduces new and emergingmedical applications of metalloproteins. Readers will discover boththe underlying chemistry and biology of this important area ofresearch in bioinorganic chemistry.
Chemistry of Metalloproteins features a building blockapproach that enables readers to master the basics and then advanceto more sophisticated topics. The book begins with a generalintroduction to bioinorganic chemistry and metalloproteins. Next,it covers:
* Alkali and alkaline earth cations
* Metalloenzymes
* Copper proteins
* Iron proteins
* Vitamin B12
* Chlorophyll
Chapters are richly illustrated to help readers fully grasp allthe chemical concepts that govern the biological action ofmetalloproteins. In addition, each chapter ends with a list ofsuggested original research articles and reviews for furtherinvestigation of individual topics.
Presenting our most current understanding of metalloproteins,Chemistry of Metalloproteins is recommended for students andresearchers in coordination chemistry, biology, and medicine.
Each volume of the Wiley Series in Protein and Peptide Scienceaddresses a specific facet of the field, reviewing the latestfindings and presenting a broad range of perspectives. The volumesin this series constitute essential reading for biochemists,biophysicists, molecular biologists, geneticists, cell biologists,and physiologists as well as researchers in drug design anddevelopment, proteomics, and molecular medicine with an interest inproteins and peptides.

Autoren/Hrsg.

Stephanos, Joseph J.

Addison, Anthony W.

Inhaltsverzeichnis

Preface ix
1 Introduction 1
Proteins: Formation, Structures, and Metalloproteins, 4
References, 28
2 Alkali and Alkaline Earth Cations 31
References, 67
3 Nonredox Metalloenzymes 71
Carboxypeptidases, 75
Carbonic Anhydrase, 84
Alcohol Dehydrogenase, 88
References, 91
4 Copper Proteins 95
Introduction, 95
Electronic Spectra of Copper Ions, 96
ESR Spectra of Copper Ions, 105
Copper Proteins, 117
Plastocyanin, 119
Azurin and Stellacyanin, 127
Superoxide Dismutase, 131
Hemocyanin, 135
Ascorbic Oxidase, 139
References, 142
5 Iron Proteins 147
Introduction, 147
Electronic Spectra of Iron Ions, 148
Mössbauer Spectroscopy of Iron Ions, 155
ESR Spectra of Iron (III), 161
Iron Bioavailability, 166
Siderophores, 171
Iron Storage and Transfer Proteins, 184
Ferritin, 184
Transferrin, 187
Dioxygenase Iron Proteins, 195
Iron-Sulfur Proteins, 207
Rubredoxin, 207
Ferredoxins, 212
2Fe-2S Ferredoxins, 212
4Fe-4S Ferredoxins, 221
Aconitase, 226
Hydroxylases, 229
Hydrogenases, 232
Nitrogenases, 240
Binuclear Iron Proteins, 251
Hemerythrin, 253
Ribotide Reductase, Purple Acid Phosphate, and MethaneMonooxygenase, 260
Hemoproteins: Classification and Behavior of Heme in Absence ofGlobins, 267
Myoglobin and Hemoglobin, 275
Myoglobin, 275
Hemoglobin, 280
Cytochrome C, 298
Electron Transfer in Porphyrins and Metalloporphyrins, 301
Catalases, 311
Peroxidases, 315
Cytochrome P-450, 322
Electronic Spectra of Hemoproteins, 327
ESR Spectra of Hemoproteins, 362
References, 378
6 Vitamin B12 393
References, 405
7 Chlorophyll 407
References, 421
Index 423

Über Autor(innen)

JOSEPH J. STEPHANOS, PHD, is AssociateProfessor of Bioinorganic, Biophysical, and Inorganic Chemistry atMenofia University. His research examines metalloprotein chemistry,ligand-binding, and coordination chemistry of biologically activecompounds.
ANTHONY W. ADDISON, PHD, is Professor ofInorganic Chemistry at Drexel University. His research focuses onbioinorganic chemistry; chemistry of dioxygen- and NO-bindingmetalloproteins; and the design, synthesis, and properties of novelchelating agents and macrocyclic and oligonuclear metal complexes.His numerous research articles and conference presentations haveearned over 8,000 citations and a Hirsch Index of 37.