Stuart The Chemistry of Natural Products

Main Lectures Presented at the Fourth International Symposium on the Chemistry of Natural Products Held in Stockholm, Sweden, 26 June-2 July, 1966
1. Auflage 2013
ISBN: 978-1-4832-8053-0
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 222 Seiten, Web PDF

The Chemistry of Natural Products 4 covers the proceedings of the Fourth International Symposium on the Chemistry of Natural Products. This book is composed of fourteen chapters, and begins with a discussion on the impact of natural product chemistry on medicine and the general methods for the construction of complex molecules. Considerable chapters are devoted to the biosynthesis, physico-chemical properties, reactions, and applications of some natural products, including polysaccharides, hormones, ginkgolides, indole, and alkaloids. The remaining chapters highlight the field of chemotaxonomy. This book will prove useful to botanists, chemists, taxonomists, and students.

Dr. Sam Stuart is a physiotherapist and a research Fellow within the Balance Disorders Laboratory, OHSU. His work focuses on vision, cognition and gait in neurological disorders, examining how technology-based interventions influence these factors. He has published extensively in world leading clinical and engineering journals focusing on a broad range of activities such as real-world data analytics, algorithm development for wearable technology and provided expert opinion on technology for concussion assessment for robust player management. He is currently a guest editor for special issues (sports medicine and transcranial direct current stimulation for motor rehabilitation) within Physiological Measurement and Journal of NeuroEngineering and Rehabilitation, respectively.

Autoren/Hrsg.

Stuart, Sam

Inhaltsverzeichnis

1;Front Cover;1
2;The Chemistry of Natural Products 4;5
3;Copyright Page;6
4;Table of Contents;8
5;CHAPTER 1. THE IMPACT OF NATURAL PRODUCT CHEMISTRY ON MEDICINE;9
5.1;INTRODUCTION;9
5.2;CONTRIBUTIONS FROM SWEDEN;9
5.3;TRADITIONAL ALKALOIDS;10
5.4;MAGNITUDE OF THE CANCER CHALLENGE;12
5.5;AMINO ACIDS OF PRIMARY IMPORTANCE;12
5.6;HEART DISEASE AND STROKE—THE GREATEST CHALLENGE;14
5.7;MALARIA—NOT YET UNDER CONTROL;15
5.8;19-NOR-STEROIDS—FERTILITY CONTROL;17
5.9;VITAMINS AND COENZYMES;18
5.10;References;29
6;CHAPTER 2. GENERAL METHODS FOR THE CONSTRUCTION OF COMPLEX MOLECULES;31
6.1;PART I. GENERAL PRINCIPLES FOR THE FORMULATION OF ASYNTHETIC PLAN;31
6.2;PART II. METHODOLOGY OF INDIVIDUAL STEPS;42
6.3;References;48
7;SECTION I: POLYSACCHARIDES;51
7.1;CHAPTER 3. INTRODUCTORY REMARKS BY THE HONORARYPRESIDENT OF THE SECTION;51
7.2;CHAPTER 4. THE EXUDATE GUMS AND THEIR STRUCTURAL RELATIONSHIP TO OTHER GROUPS OF PLANT POLYSACCHARIDES;55
7.2.1;References;67
7.3;CHAPTER 5. THE CHEMICAL STRUCTURE OF THE CELL WALL OF GRAM-POSITIVE BACTERIA;69
7.3.1;I. INTRODUCTION;69
7.3.2;II. ISOLATION, DEGRADATION, AND FRACTIONATION OF M. LYSODEIKTICUS CELL WALLS;70
7.3.3;III. CHEMICAL STRUCTURE OF ISOLATED FRAGMENTS;77
7.3.4;IV. TENTATIVE CHEMICAL STRUCTURE OF THE CARBOHYDRATE MOIETY;80
7.3.5;V. PRESENT STATUS OF MURAMIC ACID CHEMISTRY;81
7.3.6;VI. LYSOZYME SUBSTRATES;82
7.3.7;CONCLUSION;83
7.3.8;References;83
8;SECTION 2: STRUCTURAL ELUCIDATION OF NATURAL PRODUCTS OTHER THAN MACROMOLECULAR COMPOUNDS;85
8.1;CHAPTER 6. INTRODUCTORY REMARKS BY THE HONORARY PRESIDENT OF THE SECTION;85
8.2;CHAPTER 7. THE CHEMISTRY OF INSECT HORMONES AND INSECT PHEROMONES;89
8.2.1;I. INSECT HORMONES;89
8.2.2;II. INSECT PHEROMONES;96
8.2.3;References;100
8.3;CHAPTER 8. THE GINKGOLIDES;103
8.3.1;I. INTRODUCTION;103
8.3.2;II. ISOLATION OF GINKGOLIDES;104
8.3.3;III. STRUCTURE OF THE GINKGOLIDES;105
8.3.4;IV· STEREOCHEMISTRY OF THE GINKGOLIDES;120
8.3.5;V. THE NUCLEAR OVERHAUSER EFFECT (NOE);122
8.3.6;VI. N.M.R. SPECTRA OF GINKGOLIDES A, B and C;124
8.3.7;VIII· FULL STRUCTURE OF THE FOUR GINKGOLIDES;126
8.3.8;References;127
9;SECTION 3: BIOSYNTHESIS;129
9.1;CHAPTER 9. INTRODUCTORY REMARKS BY THE HONORARY PRESIDENT OF THE SECTION
;129
9.2;CHAPTER 10. BIOSYNTHESIS OF THE INDOLE AND COLCHICUM ALKALOIDS
;131
9.2.1;References;149
9.3;CHAPTER 11. BIOSYNTHETIC PATHWAYS FROM ACETATE TO NATURAL PRODUCTS;151
9.3.1;INTRODUCTION;151
9.3.2;BIOSYNTHETIC PATHWAY via "ISOPRENE RULE";151
9.3.3;BIOSYNTHETIC PATHWAY via "POLYACETATE RULE";164
9.3.4;References;181
10;SECTION 4: CHEMICAL TAXONOMY;185
10.1;CHAPTER 12. INTRODUCTORY REMARKS BY THE HONORARY PRESIDENT OF THE SECTION;185
10.2;CHAPTER 13. CHEMICAL CHARACTERS IN PLANT TAXONOMY: SOME POSSIBILITIES AND LIMITATIONS
;189
10.2.1;INTRODUCTION;189
10.2.2;SOME FACTORS WHICH LIMIT THE TAXONOMIC VALUE

OF CHEMICAL CHARACTERS;194
10.2.3;References;202
10.3;CHAPTER 14. PLANT CHEMOSYSTEMATICS AND PHYLOGENY;205
10.3.1;INTRODUCTION;205
10.3.2;NUMERICAL vs. PHYLETIC CLASSIFICATION;207
10.3.3;MICROMOLECULAR SYSTEMATICS;209
10.3.4;MACROMOLECULAR SYSTEMATICS;224
10.3.5;EPILOGUE;228
10.3.6;References;229