E-Book, Englisch, 96 Seiten, eBook
Reihe: BestMasters
ISBN: 978-3-658-20167-8
Verlag: Springer
Format: PDF
Kopierschutz: Wasserzeichen (»Systemvoraussetzungen)
in vitro
experiments. The computational model, which describes the hydrolysis of short fluorogenic peptides by the 20S proteasome, is calibrated to experimental data from different proteasome isoforms using an approximate Bayesian computation approach. The dynamics of proteasome inhibitors are included into the model in order to demonstrate how to modulate the inhibitor’s transport parameters for strong or isoform-specific inhibition.
Zielgruppe
Research
Autoren/Hrsg.
Weitere Infos & Material
Structure and Function of the Proteasome.- Approaches to Model Proteasome Dynamics.- Comparison of the Dynamics of Proteasome Subtypes.- Inhibitor Influence on the Catalytic Subunits.- Inhibitor Influence on a Compartmentalised Short Fluorogenic Peptide Model .