Subramanian Chiral Separation Techniques

A Practical Approach
3. vollständig überarbeitete und aktualisierte Auflage 2008
ISBN: 978-3-527-61172-0
Verlag: Wiley-VCH
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 619 Seiten, E-Book

Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.

Autoren/Hrsg.

Subramanian, Ganapathy

Inhaltsverzeichnis

1 Enantiomeric separations using macrocyclic glycopeptide stationary phases
2 The Role of Polysaccharides in Chiral Separations by Liquid Chromatography and Capillary Electrophoresis
3 Analytical and preparative potential of immobilized polysaccharide-derived chiral stationary phases
4 Chiral separations using supercritical fluid chromatography
5 Chiral ligand exchange in HPLC and CE
6 Advances in Simulated Moving Bed Chromatographic separations
7 Less common applications of enantioselective HPLC using the SMB technology in the pharmaceutical industry
8 Enatiomer Separation by Chiral Crown Ether Stationary phases
9 Chiral Separation of amino acids and hydroxy acids in HPLC with copper(II) complexes added to the eluent
10 Chiral Capillary Electrophoresis
11 Techniques in preparative chiral separations
12 Separation of enantiomers using molecularly imprinted polymers
13 Enantioselective Biosensors
14 Chiral analysis using CEC-UV and CEC-MS
15 Chiral analysis using MEKC-UV and MEKC-MS
16 Polarimeter Chiral Detectors in Enantioseparations
17 Preparative Chiral Chromatography - a powerful and efficient tool in drug discovery

Über Autor(innen)

With over 30 years experience in both industry and academia, Ganapathy Subramanian is a biotechnology consultant working in the application and development of processing, purification methodologies and chromatographic systems for large-scale use in environmental science, food science, perfumery cosmetics and pharmaceuticals. He has also taught extensively in the area of food and medical technology.
A chemistry graduate from Madras, India, he gained his doctorate from the University of Glasgow for work on natural products, and his main research interests lie in the utilization of natural material separation processes and bio-conversions.
Dr. Subramanian has written and edited a number of books and articles in the field of biotechnology. For the last 10 years, he has been organizing conferences promoting the integration and knowledge exchange between academia and industry.