E-Book, Englisch, 228 Seiten
Tak New Therapeutic Targets in Rheumatoid Arthritis
1. Auflage 2009
ISBN: 978-3-7643-8238-4
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark
E-Book, Englisch, 228 Seiten
Reihe: Progress in Inflammation Research
ISBN: 978-3-7643-8238-4
Verlag: Springer
Format: PDF
Kopierschutz: 1 - PDF Watermark
This volume focuses on therapeutic targets that were identified after TNF blockade. All these targets have recently been registered or are currently under development for the treatment of rheumatoid arthritis. Each chapter explores the biological rationale of a distinct therapeutic target in great detail. Readers will discover the latest in vitro work, animal models, and results from clinical trials.
Autoren/Hrsg.
Weitere Infos & Material
1;Contents;6
2;List of contributors;8
3;Preface;11
4;B cell targets in rheumatoid arthritis;13
5;Co-stimulatory pathways in the therapy of rheumatoid arthritis;39
6;Immunobiology of IL-6 – Tocilizumab (humanised anti-IL-6 receptor antibody) for the treatment of rheumatoid arthritis;56
7;Role of IL-1 in erosive arthritis, lessons from animal models;69
8;Interleukin-15;85
9;IL-17 and Th17 cells, key players in arthritis;99
10;Role of IL-18 in inflammatory diseases;112
11;Chemokines and chemokine receptors;137
12;Signaling pathways in rheumatoid arthritis;162
13;Targeting oncostatin M in the treatment of rheumatoid arthritis;188
14;Targeting the epigenetic modifications of synovial cells;199
15;Perspectives in targeted therapy;213
16;Index;227




