Tao / Lin / Liese Biocatalysis for the Pharmaceutical Industry

Discovery, Development, and Manufacturing
1. Auflage 2009
ISBN: 978-0-470-82315-6
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 336 Seiten, E-Book

Biocatalysis is rapidly evolving into a key technology for thediscovery and production of chemicals, especially in thepharmaceutical industry, where high yielding chemo-, regio-, andenantioselective reactions are critical. Taking the latestbreakthroughs in genomics and proteomics into consideration,Biocatalysis for the Pharmaceutical Industry concisely yetcomprehensively discusses the modern application of biocatalysis todrug discovery, development, and manufacturing. Written by a teamof leading experts, the book offers deep insight into this cuttingedge field.
* Covers a wide range of topics in a systematic manner with anemphasis on industrial applications
* Provides a thorough introduction to the latest biocatalysts,modern expression hosts, state-of-the-art directed evolution, highthroughput screening, and bioprocess engineering
* Addresses frontier subjects such as emerging enzymes,metabolite profiling, combinatorial biosynthesis, metabolicengineering, and autonomous enzymes for the synthesis anddevelopment of chiral molecules, drug metabolites, andsemi-synthetic medicinal compounds and natural product analogs
* Highlights the impact of biocatalysis on green chemistry
* Contains numerous graphics to illustrate concepts andtechniques
Biocatalysis for the Pharmaceutical Industry is anessential resource for scientists, engineers, and R&D policymakers in the fine chemical, pharmaceutical, and biotechindustries. It is also an invaluable tool for academic researchersand advanced students of organic and materials synthesis, chemicalbiology, and medicinal chemistry.

Autoren/Hrsg.

Tao, Junhua

Lin, Guo-Qiang

Liese, Andreas

Inhaltsverzeichnis

1. Enzymes and Their Synthetic Applications: An Overview
2. Expression hosts for enzyme discovery and production
3. Directed Enzyme Evolution and High Throughput Screening
4. Applications of reaction engineering to industrial biotransformations
5. Chiral synthesis of pharmaceutical intermediates using oxynitrilases
6. Expanding the Scope of Aldolases as Tools for Organic Synthesis
7. Synthetic Applications of Ketoreductases and Alcohol Oxidases
8. Applications of Nitrile Hydratases and Nitrilases
9. Biosynthesis of drug metabolites
10. Application of Whole Cell Biotransformation in Pharmaceutical Industry
11. Combinatorial Biosynthesis of Pharmaceutical Natural Products
12. Metabolic engineering for the development and manufacturing of pharmaceuticals
13. Multimodular Synthases and Supporting Enzymes for Chemical Production
14. Green Chemistry with Biocatalysis for Production of Pharmaceuticals

Über Autor(innen)

Dr. Junhua Tao is co-founder and Chief Scientific Officer atBioVerdant, Inc.USA. He was the Head of the Biotransformation Groupat Pfizer Global R&D from 2000 to 2005. Trained in syntheticorganic chemistry, Dr. Tao has published over 50 papers and serveas an advisory board member of Engineering in Life Sciences
Prof. Guo-Qiang Lin is a professor at Shanghai Instituteof Organic Chemistry, the Chinese Academy of Sciences, China. Withover 150 publications, Prof. Lin is well recognized in syntheticorganic chemistry and medicinal chemistry. He is associate editorsfor three journals in the fields and an Executive Board Member forTetrahedron.
Prof. Andreas Liese is Professor of TechnicalBiochemistry and Head of Institute of Technical Biocatalysis,Hamburg University of Technology, Germany. Worked in both academiaand pharmaceutical industry, Prof. Liese has made significantcontributions to industrial biotransformations, enzyme technologyand biochemical engineering. He is a member of the editorial board,Journal of Molecular Catalysis B and has published over 50 papersand 2 books.