Testa Advances in Drug Research

1. Auflage 2013
ISBN: 978-1-4832-6543-8
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 20, 332 Seiten, Web PDF

Reihe: Advances in Drug Research

Advances in Drug Research, Volume 20 focuses on the general themes of drug research and description of specific drug classes. This book is divided into four chapters. Chapter 1 discusses the extrapolation of toxicological and pharmacological data from animals to humans. The second chapter deals with the tissue binding of drugs, considering the relative ponderal importance of tissue versus blood macromolecules. The therapeutic use of plants and consumption of medicinal plants are elaborated in Chapter 3. The last chapter covers the field of histaminergic agonists and antagonists, describing breakthroughs such as H2-receptor antagonists, non-sedating H1-receptor antagonists, and H3-receptors. This publication is valuable to drug researchers and students interested in advances in drugs.

Autoren/Hrsg.

Testa, Bernard

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Drug Research;4
3;Copyright Page;5
4;Table of Contents;6
5;CONTRIBUTORS;8
6;PREFACE: "ONE SCORE VOLUMES, AND A DIET";10
7;Chapter 1. Extrapolation of Toxicological and Pharmacological Data from Animals to Humans;14
7.1;1 Overview;15
7.2;2 Introduction;19
7.3;3 The Surface Area Law;23
7.4;4 Allometric Relationships and Biological Similarity;46
7.5;5 Pharmacokinetics and Comparative Metabolism;78
7.6;6 Discussion and Conclusions;121
7.7;References;125
8;Chapter 2. Tissue Binding versus Plasma Binding of Drugs: General Principles and Pharmacokinetic Consequences;130
8.1;1 Introduction;131
8.2;2 Pharmacokinetic Consequences of Plasma and Tissue Binding;132
8.3;3 Methods to Assess Tissue Binding of Drugs;138
8.4;4 Tissue Binding versus Plasma Binding of Drugs;156
8.5;5 Conclusion;172
8.6;References;173
9;Chapter 3. Search for New Drugs of Plant Origin;180
9.1;1 Introduction;180
9.2;2 Anticancer Agents from Higher Plants;183
9.3;3 Antagonists of Platelet-activating Factor;200
9.4;4 Antimalarial Agents;206
9.5;5 AIDS—Antiviral Agents;216
9.6;6 Miscellaneous;218
9.7;7 Concluding Remarks;221
9.8;References;222
10;Chapter 4. Histaminergic Agonists and Antagonists: Recent Developments;230
10.1;1 Introduction;231
10.2;2 Histamine H1-Receptor Ligands;231
10.3;3 Histamine H2-Receptor Ligands;260
10.4;4 Histamine H3-Receptor Ligands;301
10.5;5 Concluding Remarks;310
10.6;References;310
11;SUBJECT INDEX;318
12;CUMULATIVE INDEX OF AUTHORS;328
13;CUMULATIVE INDEX OF TITLES;330