E-Book, Englisch, Band Volume 22, 216 Seiten, Web PDF
Reihe: Advances in Drug Research
Testa Advances in Drug Research
1. Auflage 2013
ISBN: 978-1-4832-6689-3
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark
E-Book, Englisch, Band Volume 22, 216 Seiten, Web PDF
Reihe: Advances in Drug Research
ISBN: 978-1-4832-6689-3
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark
Advances in Drug Research, Volume 22 focuses on the concepts and facts of drug research. This book is divided into four chapters. Chapter 1 discusses the use of atomic properties and atom-centered indices in QSAR models, while Chapter 2 describes the pharmacokinetics of peptides and proteins. The nuclear receptors, emphasizing the aspects of molecular and genomic pharmacology are elaborated in Chapter 3. The last chapter covers the medicinal chemistry of a vast group of agents acting on nuclear receptors. This publication is valuable to drug researchers and students interested in advances in drugs.
Autoren/Hrsg.
Weitere Infos & Material
1;Front Cover;1
2;Advances in Drug Research;4
3;Copyright Page;5
4;Table of Contents;6
5;CONTRIBUTORS;8
6;PREFACE: "All mimsy were the borogoves";9
7;Chapter 1. Atom Description in QSAR Models: Development and Use of an Atom Level Index;12
7.1;1 Introduction;13
7.2;2 An Atom Level Description of Structure;16
7.3;3 Formulation of an Atom-Centred Index;19
7.4;4 Information from Electrotopological State Values;26
7.5;5 QSAR Strategy;31
7.6;6 Applications to Drug QSAR Problems;34
7.7;7 Discussion;46
7.8;References;48
8;Chapter 2. Pharmacokinetics of Peptides and Proteins: Opportunities and Challenges;50
8.1;1 Introduction;52
8.2;2 Physicochemical Factors and Passive Distribution;65
8.3;3 Clearance;86
8.4;4 Transport of Peptides Across Mucosal Surfaces;103
8.5;5 Conclusions;109
8.6;References;112
9;Chapter 3. Towards Genomic Pharmacology: From Membranal to Nuclear Receptors;118
9.1;1 Introduction;119
9.2;2 Regulation of Gene Expression;120
9.3;3 Nuclear Receptors;126
9.4;4 Induced Changes in Gene Expression;135
9.5;5 The Nucleus as a Target for Drug Action;144
9.6;6 Signal Pathways: From Membrane to Nuclear Receptors;147
9.7;7 Future Prospects;153
9.8;Acknowledgements;154
9.9;References;154
10;Chapter 4. Medicinal Chemistry of Steroids: Recent Developments;160
10.1;1 Introduction;160
10.2;2 Steroid Receptors;161
10.3;3 Steroid-Converting Enzymes: The Case of 3-Oxo-.5-Steroid Isomerase;173
10.4;4 Inhibitors of Steroid-Converting Enzymes;179
10.5;5 Oestrogen Receptor-Based Imaging Agents;192
10.6;6 Conclusions and Future Developments;194
10.7;References;195
11;SUBJECT INDEX;202
12;CUMULATIVE INDEX OF AUTHORS;212
13;CUMULATIVE INDEX OF TITLES;214
