Testa Advances in Drug Research

1. Auflage 2013
ISBN: 978-1-4832-8797-3
Verlag: Elsevier Science & Techn.
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, Band Volume 17, 479 Seiten, Web PDF

Reihe: Advances in Drug Research

This volume comprises five authoritative reviews on timely topics in drug research. The first two chapters deal with chemotherapeutic agents (selective antiviral agents and cepham antibiotics) and subsequent chapters deal with the cardiovascular system and topics in neuropharmacology.

Autoren/Hrsg.

Testa, Bernard

Inhaltsverzeichnis

1;Front Cover;1
2;Advances in Drug Research;4
3;Copyright Page;5
4;Table of Contents;6
5;CONTRIBUTORS;10
6;PREFACE: TEXT AND CONTEXT;12
6.1;Reference;13
7;Chapter 1. Recent Advances in the Search for Selective Antiviral Agents;14
7.1;1 Introduction;14
7.2;2 Herpesvirus Infections;19
7.3;3 DNA Virus Infections in General;35
7.4;4 RNA Virus Infections in General;40
7.5;5 Rhinovirus Infections;47
7.6;6 Retrovirus Infections;49
7.7;7 Conclusion;58
7.8;Acknowledgements;59
7.9;References;61
8;Chapter 2. Recent Developments in the Field of Cephem Antibiotics;74
8.1;1 Introduction;75
8.2;2 General Aspects and Characteristics;77
8.3;3 Naturally Occurring Cephalosporins;88
8.4;4 Chemical Variations and Biological Activity;96
8.5;5 Compounds on the Market and under Development;178
8.6;7 Perspectives;221
8.7;Acknowledgements;222
8.8;References;222
9;Chapter 3. Recent Experimental and Conceptual Advances in Drug Receptor Research in the Cardiovascular System;248
9.1;1 Control of the Cardiovascular System;250
9.2;2 a-Adrenoceptors;252
9.3;3 ß-Adrenoceptors;294
9.4;4 Dopamine Receptors;303
9.5;5 Serotonin (5HT) Receptors;310
9.6;6 Eicosanoid Receptors;315
9.7;7 Angiotensin II Receptors;328
9.8;8 Purinergic Receptors;333
9.9;9 Vasopressin Receptors;339
9.10;10 Concluding Remarks;344
9.11;References;345
10;Chapter 4. The Pharmacology and Therapeutic Potential of Serotonin Receptor Agonists and Antagonists;362
10.1;1 Introduction;363
10.2;2 Sites of Intervention in Serotonergic Neuron Function;363
10.3;3 Serotonin Receptor Heterogeneity;365
10.4;4 Direct-acting Serotonin Agonists;370
10.5;5 Serotonin Antagonists;376
10.6;6 Therapeutic Uses of Serotonergic Drugs;380
10.7;7 Conclusion;386
10.8;References;387
11;Chapter 5. Recent Advances in GABA Agonists,Antagonists and Uptake Inhibitors:Structure–Activity Relationships and Therapeutic Potential;394
11.1;1 Introduction;395
11.2;2 Multiplicity of GABA-Operated Synaptic Mechanisms;396
11.3;3 Postsynaptic GABA-A Receptor Complex;400
11.4;4 Presynaptic and Extrasynaptic GABA-A Receptors;433
11.5;5 GABA-A Autoreceptors;435
11.6;6 GABA-B Receptors;436
11.7;7 GABA Uptake Mechanisms as Pharmacological Targets;442
11.8;8 Conclusions;457
11.9;Acknowledgements;458
11.10;References;460
12;SUBJECT INDEX;472
13;CUMULATIVE INDEX OF AUTHORS;490
14;CUMULATIVE INDEX OF TITLES;492